Polymorphism in the 5’‑noncoding region of the bovine growth hormone receptor gene and its association with meat production traits in cattle

Maj, Andrzej; Oprządek, J.; Oprzadek, A.; Dymnicki, E.; Zwierzchowski, L.

doi:10.1051/animres:2004038

Cited by 23 publications

(17 citation statements)

References 25 publications

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“…Other studies have reported significant associations between GHR and productivity traits in cattle such as growth and carcass traits in Zebu and crossbred cattle (Curi et al, 2006) and carcass weight, percentage of valuable cuts, ADG, and FCR (Maj et al, 2004).…”

Section: Single Nueleotide Polymorphisms With An Effect On the Structmentioning

confidence: 94%

Candidate genes and single nucleotide polymorphisms associated with variation in residual feed intake in beef cattle1

Karisa

Thomson

Wang

et al. 2013

Journal of Animal Science

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The candidate gene approach was used to identify genes associated with residual feed intake (RFI) in beef steers. The approach uses prior knowledge of gene functions to predict their biological role in the variation observed in a trait. It is suited to identify genes associated with complex traits where each gene has a relatively small effect. First, positional candidate genes were identified within the genomic positions of previously reported QTL associated with component traits related to RFI such as dry matter intake (DMI), growth, feed conversion ratio (FCR), average daily gain (ADG), and energy balance. Secondly, the positional candidate genes were prioritized into functional candidate genes according to their biological functions and their relationship with the biological processes associated with RFI including carbohydrate, fat and protein metabolism, thermoregulation, immunity and muscle activity. Single nucleotide polymorphisms (SNPs) located within the functional candidate genes were identified using mRNA sequences and prioritized into functional classes such as non-synonymous (nsSNP), synonymous (sSNP) or intronic SNP. A total of 117 nsSNP were considered as functional SNP and genotyped in steers at the University of Alberta ranch in Kinsella. Multiple marker association analysis in ASReml was performed using RFI data obtained from 531 beef steers. Twenty-five SNP were significantly associated with RFI (P < 0.05) accounting for 19.7% of the phenotypic variation. Using SIFT program to predict the effect of the SNP on the function of the corresponding protein, 3 of the 25 SNP were predicted to cause a significant effect on protein function (P < 0.05). One of the 3 SNP was located in the GHR gene and was also associated with a significant effect on the tertiary structure of the GHR protein (P < 0.05) as modeled using SWISSModel software. Least square means for each genotype were estimated and an over-dominance effect was observed for the SNP located in the GHR, CAST, ACAD11 and UGT3A1 genes. In addition, 2 other SNP showed a dominance effect and 3 genes had an additive effect. Gene network analysis performed in Ingenuity pathway analysis (IPA) software (Ingenuity Systems, www.ingenuity.com) indicated that the significant genes were involved in biological pathways such as lipid, protein and energy metabolism, electron transport and membrane signaling. The genes in this study, if validated in other beef cattle populations, may be useful for marker assisted selection for feed efficiency.

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Section: Single Nueleotide Polymorphisms With An Effect On the Structmentioning

confidence: 94%

Candidate genes and single nucleotide polymorphisms associated with variation in residual feed intake in beef cattle1

Karisa

Thomson

Wang

et al. 2013

Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…Este SNP fue identificado previamente por Ge et al (1999) y analizado para las asociaciones con características de crecimiento con niveles séricos de IGF1 en sangre (Ge et al, 2003). También se evaluó para las asociaciones con características de producción de carne (Maj et al, 2004(Maj et al, , 2006 et al (2008). Los análisis de re-secuenciación revelaron diferencias en la región promotora de GHR entre ganado Brahman (Bos indicus) y razas de Bos taurus (Garret et al, 2008).…”

Section: Resultados Y Discusiónunclassified

Evaluación de panel SNP en genes candidatos de vías metabólicas para carne en Hereford

et al. 2014

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“…1999). In addition, RFLP‐Alu I and RFLP‐Acc I located in the LINE‐1 sequence were associated with meat production in cattle (Maj et al. 2004).…”

Section: Resultsmentioning

confidence: 99%

Bos indicus type of growth hormone receptor gene is retained in Japanese Black cattle

Ohkubo¹,

Yano²,

Takahashi³

et al. 2006

J Animal Breeding Genetics

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The growth hormone receptor (GHR) gene is responsible for growth and carcass traits, and polymorphisms associated with the variation of meat production are thought to occur in the liver-specific promoter of the GHR gene in cattle. The aim of this study was to analyse the structure of the liver-specific promoter of GHR in Japanese Black cattle, as the relationship between GHR polymorphism and meat production is poorly understood in this breed. Typically in European cattle, the LINE-1 element, a family of retrotransposons, is inserted in the liver-specific promoter. However, a short GHR promoter without the LINE-1 sequence was found in the Japanese Black breed as in Bos indicus cattle. The frequency of the short allele was approximately 60%. In addition, 24 of 29 Holstein/Japanese Black crosses carried the short allele from their sire. The present result suggests that the short allele for GHR may be a candidate marker for improving meat production of Japanese Black cattle.

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Polymorphism in the 5’‑noncoding region of the bovine growth hormone receptor gene and its association with meat production traits in cattle

Cited by 23 publications

References 25 publications

Candidate genes and single nucleotide polymorphisms associated with variation in residual feed intake in beef cattle1

Candidate genes and single nucleotide polymorphisms associated with variation in residual feed intake in beef cattle1

Evaluación de panel SNP en genes candidatos de vías metabólicas para carne en Hereford

Bos indicus type of growth hormone receptor gene is retained in Japanese Black cattle

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