Polymorphism in the promoter of the gene for the serotonin transporter affects the age of onset of major depressive disorder in the Japanese population

Watanabe, Shinya; Iga, Jun‐ichi; Numata, Shusuke; Umehara, Hiroki; Nishi, Akira; Kinoshita, Makoto; Inoshita, Masatoshi; Ohmori, Tetsuro

doi:10.1016/j.jad.2015.05.009

Cited by 8 publications

(7 citation statements)

References 20 publications

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“…The search for the relationship between genetic and personal psychological characteristics in healthy people shows that such relationships are reliably detected in groups of people living in approximately the same socio-climatic conditions [11,12]. Associations between genetic and psychological characteristics identified in one of these groups may not be observed, or may even vary to the extent of inverse relationship, in other groups of people [11,13,14,15]. A similar situation is observed for the study of the relationship between neurophysiological (brain electrophysiological or hemodynamic activity), behavioral, and psychological characteristics of healthy people and clinical patients.…”

Section: Introductionmentioning

confidence: 99%

Reconstruction and Analysis of Gene Networks of Human Neurotransmitter Systems Reveal Genes with Contentious Manifestation for Anxiety, Depression, and Intellectual Disabilities

Ivanov

Zamyatin

Klimenko

et al. 2019

Genes

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Background: The study of the biological basis of anxiety, depression, and intellectual disabilities in humans is one of the most actual problems of modern neurophysiology. Of particular interest is the study of complex interactions between molecular genetic factors, electrophysiological properties of the nervous system, and the behavioral characteristics of people. The neurobiological understanding of neuropsychiatric disorders requires not only the identification of genes that play a role in the molecular mechanisms of the occurrence and course of diseases, but also the understanding of complex interactions that occur between these genes. A systematic study of such interactions obviously contributes to the development of new methods of diagnosis, prevention, and treatment of disorders, as the orientation to allele variants of individual loci is not reliable enough, because the literature describes a number of genes, the same alleles of which can be associated with different, sometimes extremely different variants of phenotypic traits, depending on the genetic background, of their carriers, habitat, and other factors. Results: In our study, we have reconstructed a series of gene networks (in the form of protein–protein interactions networks, as well as networks of transcription regulation) to build a model of the influence of complex interactions of environmental factors and genetic risk factors for intellectual disability, depression, and other disorders in human behavior. Conclusion: A list of candidate genes whose expression is presumably associated with environmental factors and has potentially contentious manifestation for behavioral and neurological traits is identified for further experimental verification.

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Section: Introductionmentioning

confidence: 99%

Reconstruction and Analysis of Gene Networks of Human Neurotransmitter Systems Reveal Genes with Contentious Manifestation for Anxiety, Depression, and Intellectual Disabilities

Ivanov

Zamyatin

Klimenko

et al. 2019

Genes

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“… 47 The contradictory trends of the clinical features of MDD patients associated with spring/summer birth cannot be simply explained. Based on the links between polymorphism in the serotonin transporter-linked polymorphic region (5- HTTLPR ) and age at onset, and between 5- HTTLPR polymorphism and self-directedness, 48 49 we may surmise that the contradictory trends are partly connected with the actions of 5-HT. 5-HT has paradoxical effects of the following kinds: functional impairment of anterior 5-HT cells (dorsal raphe nucleus) can result in sensitization of the dopamine system leading to impulsivity and addiction, whereas functional impairment of posterior 5-HT cells (median raphe nucleus) innervating the hippocampus and cingulated gyrus, can result in melancholic mood, low self-esteem, and hopelessness.…”

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confidence: 99%

Potential Relationship between Season of Birth and Clinical Characteristics in Major Depressive Disorder in Koreans: Results from the CRESCEND Study

et al. 2016

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We aimed to examine the potential relationship between season of birth (SOB) and clinical characteristics in Korean patients with unipolar non-psychotic major depressive disorder (MDD). Using data from the Clinical Research Center for Depression (CRESCEND) study in South Korea, 891 MDD patients were divided into two groups, those born in spring/summer (n=457) and those born in autumn/winter (n=434). Measurement tools comprising the Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Brief Psychiatric Rating Scale, Scale for Suicidal Ideation, Clinical Global Impression of severity, Social and Occupation Functional Assessment Scale, WHO Quality of Life assessment instrument-abbreviated version, Alcohol Use Disorder Identification Test, and Temperament and Character Inventory were used to evaluate depression, anxiety, overall symptoms, suicidal ideation, global severity, social function, quality of life, drinking, and temperament and character, respectively. Using independent t-tests for continuous variables and χ2 tests for discrete variables, the clinical characteristics of the two groups were compared. MDD patients born in spring/summer were on average younger at onset of first depressive episode (t=2.084, p=0.038), had greater loss of concentration (χ2=4.589, p=0.032), and were more self-directed (t=2.256, p=0.025) than those born in autumn/winter. Clinically, there was a trend for the MDD patients born in spring/summer to display the contradictory characteristics of more severe clinical course and less illness burden; this may have been partly due to a paradoxical effect of the 5-HT system.

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“…Our findings suggest variations in allelic frequency and functionality of 5-HTTLPR and rs25531 among the different ethnicities. Forty-three percent for S allele frequency and 19.5 % for SS genotype frequency of 5-HTTLPR in the European-Americans, 25 % for S allele frequency and 6.3 % for SS genotype frequency in the African-Americans, and 82 % for S allele frequency and 66 % for SS genotype frequency in the Japanese were reported in previous literature [10,28,29]. In agreement with previous findings [3,5,6], individuals with 5-HTTLPR SS genotype were more prevalent in our Korean sample (76.3 % for S allele frequency and 58.8 % for SS genotype frequency).…”

Section: Discussionmentioning

confidence: 62%

5-HTTLPR-rs25531 and Antidepressant Treatment Outcomes in Korean Patients with Major Depression

et al. 2021

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Introduction Despite the ethnic differences in 5-HTTLPR (S allele relates to better antidepressant response in Korean and Japanese people, while L allele with better response in Caucasians), it is unclear whether 5-HTTLPR and its high expression locus rs25531 are interactively associated with antidepressant treatment outcome. We investigated the individual and interaction effects of these polymorphisms on antidepressant treatment outcomes in the Korean population. Methods A total of 464 Korean subjects with major depressive disorder completed 6 weeks of antidepressant monotherapy. Venous blood was extracted for genotyping 5-HTTLPR and rs25531 by polymerase chain reaction and DNA sequencing. We used logistic regression analyses to verify the main and interaction effects of 5-HTTLPR and rs25531 on response and remission after antidepressant treatment. Results After adjusting for covariates, the SS genotype of 5-HTTLPR was significantly associated with better treatment outcomes (p<0.001, odds ratio [OR] [95% confidence interval (CI)]=2.435 [1.551, 3.823] in response; p<0.001, OR [95% CI]=2.912 [1.730, 4.903] in remission), while G-containing genotype (AG+GG) of rs25531 was only associated with remission (p=0.034, OR [95% CI]=2.104 [1.058, 4.181]). The interaction effect of 5-HTTLPR and rs25531 on response and remission was insignificant (all p>0.05). Discussion Our findings suggest variations in allelic frequency and functionality of 5-HTTLPR and rs25531 among the different ethnicities. We found a minor advantage of rs25531 in achieving remission. However, there was no interaction effect with 5-HTTLPR.

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Polymorphism in the promoter of the gene for the serotonin transporter affects the age of onset of major depressive disorder in the Japanese population

Cited by 8 publications

References 20 publications

Reconstruction and Analysis of Gene Networks of Human Neurotransmitter Systems Reveal Genes with Contentious Manifestation for Anxiety, Depression, and Intellectual Disabilities

Reconstruction and Analysis of Gene Networks of Human Neurotransmitter Systems Reveal Genes with Contentious Manifestation for Anxiety, Depression, and Intellectual Disabilities

Potential Relationship between Season of Birth and Clinical Characteristics in Major Depressive Disorder in Koreans: Results from the CRESCEND Study

5-HTTLPR-rs25531 and Antidepressant Treatment Outcomes in Korean Patients with Major Depression

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