Polymorphism of Agt, Agt2r1 and Nos3 Genes as a Risk Factor for Imbalance in Vasoactive Factors

Bebyakova, N. A.; Pervukhina, Ol’ga; Фадеева, Н А; Хромова, А В

doi:10.33396/1728-0869-2020-10-4-9

Ekologiya cheloveka (Human Ecology)

2020

DOI: 10.33396/1728-0869-2020-10-4-9

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Polymorphism of Agt, Agt2r1 and Nos3 Genes as a Risk Factor for Imbalance in Vasoactive Factors

N. A. Bebyakova

Ol’ga Pervukhina

Н А Фадеева

et al.

Abstract: Одним из ведущих механизмов развития сердечно-сосудистых заболеваний в настоящее время рассматривают эндотелиальную дисфункцию, ранним предиктором которой является дисбаланс продукции вазоактивных факторов [8, 9, 17]. Основные вазоактивные вещества, вырабатываемые эндотелием,-это оксид азота (NO), который является вазодилататором и приводит к расширению сосудов и снижению тонуса сосудов, и эндотелин-1 (ЭТ-1), который в концентрациях, превышающих физиологические, активирует рецепторы на гладкомышечных клетках с… Show more

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Polymorphism of genes involved in the regulation of blood pressure in elderly residents of the Arkhangelsk region

Levitsky,

Bebyakova,

Pechinkina

et al. 2024

Ekologiya cheloveka (Human Ecology)

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BACKGROUND: Living in the northern climate is associated with increased cardiovascular stress, which highlights the necessity for the study of candidate genes associated with the risk of cardiovascular diseases in both the native population and newcomers. Polymorphic loci of the renin-angiotensin system, NO-synthase, and endothelin-1 system genes have been identified as contributors to cardiovascular dysfunction and age-related blood pressure shifts. It is therefore crucial to assess the genetic polymorphism in the elderly population. AIM: To compare frequencies of gene alleles and genotypes involved in blood pressure regulation, including angiotensinogen AGT (rs699 and rs4762), angiotensin 2 type 1 receptor AGTR1 (rs5186), angiotensin converting enzyme ACE (rs4646994), endothelial NO synthase NOS3 and endothelin-1 EDN1 (rs5370) genes, in the native and non-native elderly population of the Arkhangelsk region. MATERIALS AND METHODS: A cross-sectional study was conducted in a random sample of Arkhangelsk residents between the ages of 60 and 74 years (N=604, with 36.4% of males). The molecular genetic analysis was conducted to determine the alleles and genotypes of six genes that are involved in blood pressure regulation. The Stata 18.0 software was used to assess the deviations of empirical genotype distributions from the predicted Hardy–Weinberg equilibrium and to compare the empirical distributions between the study groups. RESULTS: Alleles associated with the risk of cardiovascular diseases were minor in the study population. The genotype frequency distributions for the analyzed genetic variants were consistent with the Hardy–Weinberg principle, with the exception of the T704C variant of the AGT gene (rs699) in the native participants. The allele and genotype frequency distributions in the study sample were found to be similar to those reported worldwide and in European Russia. One exception was AGTR1 gene A1166C frequencies, with their 95% confidence intervals falling below the global level for both native and non-native elderly residents of the Arkhangelsk region. This may suggest that this allele is a selection variant associated with adaptation to the climate of the northern regions. CONCLUSION: The genetic polymorphism in blood pressure regulation was found to be similar between the native and non-native populations of the Arkhangelsk region. However, the AGTR1 gene A1166C frequency among the native population and newcomers was found to be lower than that observed globally.

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Polymorphism of genes involved in the regulation of blood pressure in elderly residents of the Arkhangelsk region

Levitsky,

Bebyakova,

Pechinkina

et al. 2024

Ekologiya cheloveka (Human Ecology)

View full text Add to dashboard Cite

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Prevalence of Arterial Hypertension Candidate Genes in the Newly Arrived Population of the North-East Russia

Bezmenova

2022

Ulyanovsk Medico-biological Journal

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Arterial hypertension (AH) is one of the most serious problems of modern health care. In the northern regions it has become a catastrophe, being the most common cause of early disability and mortality among the employable newly-arrived population. At high latitudes, AH is characterized by a more severe course; it is accompanied by early damage to target organs; and it is more often in young people. AH occurs as a result of a combined interaction of polymorphism in genes, which are involved in blood pressure regulation. It is also provoked by the environmental factors. The aim of the study is to assess the prevalence of polymorphisms in four AH candidate genes (AGT (rs4762), AGTR1 (rs5186), ADD1 (rs4961), NOS3 (rs2070744)) in the newly arrived population of the North-East Russia. Materials and methods. The cross-sectional study involved practically healthy unrelated men, mostly Europeans, living or born on the territory of the Magadan region (n=101). The average age of the subjects was 46.12±1.5 (20–77 years old). PCR was used to perform molecular genetic testing of genes directly involved in the work of the main blood pressure regulation systems: AGT, AGTR1, ADD1, NOS3. The author calculated phenotypic and gene frequencies, observed and expected heterozygosity levels, Wright's fixation index (D) and population genetic distance (according to Nei). Clustering methods and multidimensional scaling were used to visualize the genetic relationship of different populations. Results. In the newly arrived population of the North-East Russia, genotype distribution corresponds to the Hardy – Weinberg equilibrium (p>0.05). Allelic diversity for the studied loci varies from Ho=0.25 (AGT locus) to Ho=0.44 (eNOS locus). Conclusion. The result of the study is the revealed characteristics of AH candidate gene frequency in the newly arrived population of the North-East Russia. It is found that allelic variants that increase the risk of AH developing are minor. Their frequency varies from 13.37 % (AGT*T allele, AGT locus) to 35.64 % (eNOS*C allele, eNOS locus).

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Polymorphism of Agt, Agt2r1 and Nos3 Genes as a Risk Factor for Imbalance in Vasoactive Factors

Cited by 2 publications

References 11 publications

Polymorphism of genes involved in the regulation of blood pressure in elderly residents of the Arkhangelsk region

Polymorphism of genes involved in the regulation of blood pressure in elderly residents of the Arkhangelsk region

Prevalence of Arterial Hypertension Candidate Genes in the Newly Arrived Population of the North-East Russia

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