Polymorphism of Fas and Fas ligand in preterm premature rupture of membranes in singleton pregnancies

Fuks, Aleksandr; Parton, Lance; Polavarapu, Satya; Netta, Denise; Strassberg, Sonya; Godi, Ioana; Hsu, Chaur‐Dong

doi:10.1016/j.ajog.2005.05.082

Cited by 27 publications

(21 citation statements)

References 15 publications

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“…Eight of the ten polymorphism have been linked to PTD in reports of maternal genotype, but these associations have been inconsistent [12,14,15,33-35]. Several of our findings paralleled results from previous studies.…”

Section: Discussionsupporting

confidence: 85%

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Innate immune system gene polymorphisms in maternal and child genotype and risk of preterm delivery

Jones¹,

Holzman²,

Tian³

et al. 2011

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective There is little information about the combination of genetic variability in pregnant women and their children in relation to the risk of preterm delivery (PTD). In a sub-cohort of 487 non-Hispanic white and 288 African-American mother/child pairs, the Pregnancy Outcomes and Community Health Study assessed ten functional polymorphisms in nine genes involved in innate immune function. Methods Race-stratified weighted logistic regression models were used to calculate odds ratios for genotype and PTD/PTD subtypes. Polymorphisms significantly associated with PTD/PTD subtypes were tested for mother/child genotype interactions. Results Three maternal polymorphisms (IL-1 receptor antagonist intron two repeat (IL-1RN), matrix metalloproteinase-9 -C1562T, and TNF receptor two T198G (TNFR2)) and three child polymorphisms (IL1-RN, tumor necrosis factor-alpha -G308A, and TNFR2) were associated with PTD, but associations varied by PTD subtype and race. Two interactions were detected for maternal and child genotype. Among non-Hispanic white women, the odds of PTD was higher when both mother and child carried the IL-1RN allele two (additive interaction p<.05). Among African-American women, the odds of PTD was higher when both mother and child carried the TNFR2 G allele (multiplicative interaction p<.05). Conclusion These results highlight the importance of assessing both maternal and child genotype in relation to PTD risk.

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Section: Discussionsupporting

confidence: 85%

“…The polymorphisms were selected on the basis of published associations with PTD [11-15] and associations with variation in the extent of inflammation processes (see Table II) [7,12,16-21]. We choose to analyze polymorphisms in candidate genes rather than explore genome-wide associations.…”

Section: Introductionmentioning

confidence: 99%

Innate immune system gene polymorphisms in maternal and child genotype and risk of preterm delivery

Jones¹,

Holzman²,

Tian³

et al. 2011

The Journal of Maternal-Fetal & Neonatal Medicine

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show abstract

“…Bacteria also produce phospholipase A2 that increases matrix metalloproteinase 1 and 3 (MMP1 and MMP3), leading to ECM degradation [8], [9]. Molecular studies on the development of PPROM have been undertaken [10], with a focus on genes that are involved with inflammation [11]–[14], including TNFα [15]–[17], FAS, which is member 6 gene of the tumor necrosis factor receptor superfamily [9], [18], and Toll-like receptor (TLR) [19], [20]. TNF-α induces apoptosis in PPROM, through binding to the TNF receptor [13]–[15] and activating a proteolytic cascade via the FAS-caspase pathway [9].…”

Section: Introductionmentioning

confidence: 99%

LncRNA Pathway Involved in Premature Preterm Rupture of Membrane (PPROM): An Epigenomic Approach to Study the Pathogenesis of Reproductive Disorders

Luo

Shi

et al. 2013

PLoS ONE

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Preterm birth (PTB) is a live birth delivered before 37 weeks of gestation (GW). About one-third of PTBs result from the preterm premature rupture of membranes (PPROM). Up to the present, the pathogenic mechanisms underlying PPROM are not clearly understood. Here, we investigated the differential expression of long chain non-coding RNAs (lncRNAs) in placentas of PTBs with PPROM, and their possible involvement in the pathogenic pathways leading to PPROM. A total number of 1954, 776, and 1050 lncRNAs were identified with a microarray from placentas of PPROM (group A), which were compared to full-term birth (FTB) (group B), PTB (group C), and premature rupture of membrane (PROM) (group D) at full-term, respectively. Instead of investigating the individual pathogenic role of each lncRNA involved in the molecular mechanism underlying PPROM, we have focused on investigating the metabolic pathways and their functions to explore what is the likely association and how they are possibly involved in the development of PPROM. Six groups, including up-regulation and down-regulation in the comparisons of A vs. B, A vs. C, and A vs. D, of pathways were analyzed. Our results showed that 22 pathways were characterized as up-regulated 7 down-regulated in A vs. C, 18 up-regulated and 15 down-regulated in A vs. D, and 33 up-regulated and 7 down-regulated in A vs. B. Functional analysis showed pathways of infection and inflammatory response, ECM-receptor interactions, apoptosis, actin cytoskeleton, and smooth muscle contraction are the major pathogenic mechanisms involved in the development of PPROM. Characterization of these pathways through identification of lncRNAs opened new avenues for further investigating the epigenomic mechanisms of lncRNAs in PPROM as well as PTB.

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“…Primer sequences and polymerase chain reaction (PCR), cycling conditions have been previously described as well as genotyping methods for FAS (rs1800682) 19 and FAS-L (rs763110) 16 gene polymorphisms. The two allelic variants were genotyped using the restriction fragment length polymorphism (RFLP) method.…”

Section: Polymorphism Genotypingmentioning

confidence: 99%

“…16,19 All PCR products were visualized using electrophoresis on an agarose gel stained with bromide ethidium.…”

Section: Polymorphism Genotypingmentioning

confidence: 99%

FAS and FAS-L Genotype and Expression in Patients With Recurrent Pregnancy Loss

et al. 2013

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We assessed FAS and FAS-L gene polymorphisms and messenger RNA (mRNA) levels in patients with recurrent pregnancy loss (RPL). This case-control study compared 129 women with RPL with 235 healthy multiparous women (control group). Genomic DNA and total mRNA were extracted from whole blood, and polymorphisms genotyping was performed by polymerase chain reaction (PCR). Messenger RNA expression levels were analyzed by real-time PCR. Data were analyzed by chi-square and Fisher exact tests; P < .05 was considered significant. There were no significant differences in the FAS (670 A/G) genotype or allelic frequencies between the RPL and control groups. We found significant differences in the FAS-L (844 C/T) genotype and allelic frequencies between women with RPL and controls. Patients with RPL had significantly higher FAS-L expression. Our data suggest that FAS-L gene polymorphism is associated with increased susceptibility to RPL. Moreover, women with RPL seem to abnormally express FAS-FAS-L molecules.

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Polymorphism of Fas and Fas ligand in preterm premature rupture of membranes in singleton pregnancies

Cited by 27 publications

References 15 publications

Innate immune system gene polymorphisms in maternal and child genotype and risk of preterm delivery

Innate immune system gene polymorphisms in maternal and child genotype and risk of preterm delivery

LncRNA Pathway Involved in Premature Preterm Rupture of Membrane (PPROM): An Epigenomic Approach to Study the Pathogenesis of Reproductive Disorders

FAS and FAS-L Genotype and Expression in Patients With Recurrent Pregnancy Loss

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