Polymorphism of G-quadruplexes formed by short oligonucleotides containing a 3′-3′ inversion of polarity: From G:C:G:C tetrads to π–π stacked G-wires

Marzano, Maria; D'Errico, Stefano; Greco, Francesca; Falanga, Andrea Patrizia; Terracciano, Monica; Di Prisco, Daria; Piccialli, Gennaro; Borbone, Nicola; Oliviero, Giorgia

doi:10.1016/j.ijbiomac.2023.127062

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2024

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Cited by 3 publications

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Exploring versatility: Investigating nanomaterials applications in relation to polymorphism

Anjaneyulu,

Chinmay,

Tiwari

et al. 2024

Journal of Molecular Structure

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Exploring versatility: Investigating nanomaterials applications in relation to polymorphism

Anjaneyulu,

Chinmay,

Tiwari

et al. 2024

Journal of Molecular Structure

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NMR of proteins and nucleic acids

Andrew Atkinson

2024

Nuclear Magnetic Resonance

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A CD Study of a Structure-Based Selection of N-Heterocyclic Bis-Carbene Gold(I) Complexes as Potential Ligands of the G-Quadruplex-Forming Human Telomeric hTel23 Sequence

Marzano,

Prencipe,

Delre

et al. 2024

Molecules

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Herein, we report the structure-based selection via molecular docking of four N-heterocyclic bis-carbene gold(I) complexes, whose potential as ligands for the hTel23 G-quadruplex structure has been investigated using circular dichroism (CD) spectroscopy, CD melting, and polyacrylamide gel electrophoresis (PAGE). The complex containing a bis(1,2,3,4,6,7,8,9-octahydro-11H-11λ3-pyridazino[1,2-a]indazol-11-yl) scaffold induces a transition from the hybrid (3 + 1) topology to a prevalent parallel G-quadruplex conformation, whereas the complex featuring a bis(2-(2-acetamidoethyl)-3λ3-imidazo[1,5-a]pyridin-3(2H)-yl) moiety disrupted the original G-quadruplex structure. These results deserve particular attention in light of the recent findings on the pathological involvements of G-quadruplexes in neurodegenerative diseases.

show abstract

Polymorphism of G-quadruplexes formed by short oligonucleotides containing a 3′-3′ inversion of polarity: From G:C:G:C tetrads to π–π stacked G-wires

Cited by 3 publications

References 56 publications

Exploring versatility: Investigating nanomaterials applications in relation to polymorphism

Exploring versatility: Investigating nanomaterials applications in relation to polymorphism

NMR of proteins and nucleic acids

A CD Study of a Structure-Based Selection of N-Heterocyclic Bis-Carbene Gold(I) Complexes as Potential Ligands of the G-Quadruplex-Forming Human Telomeric hTel23 Sequence

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