Polymorphism of Genes of the System of Biotransformation of Xenobiotics in Patients With Occupational Allergic Dermatoses

Измеров, Н Ф; Kuzmina, Lyudmila P.; Коляскина, М. М.; Безрукавникова, Людмила Михайловна; Лазарашвили, Н А; Петинати, Яна Александровна

doi:10.15690/vramn.v67i7.339

Cited by 4 publications

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“…Накопление знаний в области молекулярно-генетических исследований способствует активному изучению взаимосвязи между отдельными аллельными генами и патологическими процессами [6]. Новые возможности в диагностике позволили не только изменить взгляд на эффективность и безопасность назначаемых препаратов, но и пополнить знания о процессах развития многих заболеваний.…”

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A study of the effect of gene polymorphism of xenobiotic biotransformation system, matrix metalloproteinases and interleukins on the development and course of distal neuropathy and diabetic foot syndrome in patients with type 1 and type 2 diabetes mellitus

Denisiukova

Ivanova

Pavlyuchenko

et al. 2023

Aspirantskiy Vestnik Povolzhiya

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Aim to improve the effectiveness of early diagnosis, prediction and therapy of distal neuropathy (DN) and diabetic foot syndrome (DFS) in patients with type 1 and type 2 diabetes by identifying the features of gene polymorphism of xenobiotic biotransformation systems and antioxidant protection, pro- and anti-inflammatory cytokines. Material and methods. The study group included 150 patients aged from18 to 70 years, men and women with type 1 and type 2 diabetes, having DN and DFS, and 20 healthy people. Research methods used in the study: 1) clinical objective research; 2) molecular genetic methods; 3) population-statistics methods. Results. In patients with type 1 and type 2 diabetes with DN and DFS, the significant differences were found between the frequency of occurrence of polymorphism variants: G681A(*2) the CYP2C19 gene (2 = 9.642, p = 0.008), (OR = 0.334, (95% CI 0.145-0.768)); A8202G of the MMP9 gene (2 = 7.589, p = 0.022), (OR =0.476, (95% CI 0.226-1.005)); IIe105Val of the GSTP gene (2 = 19.521, p = 0.000), (OR = 0.174, (95% CI 0.070-0.435)); G-1293C(c1/c2) of the CYP2E gene (2 = 15.996, p = 0.000), (OR = 0.163, (95% CI 0.034-0.772)). Conclusion. Among patients suffering from type 1 and type 2 diabetes with the genotype A/A polymorphism G681A(*2) of the CYP2C19 gene, the DN and SDS are 4 times more likely to develop. The G/G polymorphism genotype A8202G of the MMP9 gene increases the risk of developing DN and DFS by almost 2 times. The genotype G/G polymorphism IIe105Val of the GSTP gene in patients increases the risk of developing DN and DFS by 4 times. The variant of the genotype C/C polymorphism G-1293C(c1/c2) of the CYP2E gene increases the risk of DN and DFS by 5 times.

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Section: Introductionunclassified

A study of the effect of gene polymorphism of xenobiotic biotransformation system, matrix metalloproteinases and interleukins on the development and course of distal neuropathy and diabetic foot syndrome in patients with type 1 and type 2 diabetes mellitus

Denisiukova

Ivanova

Pavlyuchenko

et al. 2023

Aspirantskiy Vestnik Povolzhiya

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Studying polymorphic variants of the NAT2 gene (NAT25 and NAT27) in Nenets populations of Northern Siberia

et al. 2020

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Background N-acetyltransferase 2 plays a crucial role in the metabolism of a wide range of xenobiotics, including many drugs, carcinogens, and other chemicals in the human environment. The article presents for the first time data on the frequency of two important “slow” variants of NAT2 gene (NAT2*5, rs1801280 and NAT2*7, rs1799931), which significantly affect the rate of xenobiotics acetylation, among representatives of indigenous populations of Forest and Tundra Nenets in Northern Siberia. The aim of this study was to identify the frequencies of these variants and compare them with frequencies in other ethnic populations. Results NAT2*5 (T341C) genotyping revealed frequencies of 28,0% and 38,6% for Tundra and Forest Nenets, respectively. The frequencies of NAT2*7 (G857A) variant were 9,8% and 8,2% for Tundra and Forest Nenets, respectively. Polymorphic variants frequencies for Nenets are intermediate between those in populations of Europeans and Asians. These results can probably be explained by the presence of both European and Asian components in Nenets gene pools. Conclusions The results of this study expand the knowledge of NAT2 polymorphism in world populations. These data may also help assess the genetic predisposition of Nenets to multifactorial diseases associated with polymorphism in the NAT2 gene and, in general, contribute to the development of personalized medicine in reference to native people of Siberia.

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The Changes of Rat Blood-Brain Barrier Permeability and Expression of Heat Shock Protein 70 after Infrasonic Damage

Fei

Zhang

et al. 2000

Journal of Low Frequency Noise, Vibration and Active Control

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Polymorphism of Genes of the System of Biotransformation of Xenobiotics in Patients With Occupational Allergic Dermatoses

Cited by 4 publications

References 2 publications

A study of the effect of gene polymorphism of xenobiotic biotransformation system, matrix metalloproteinases and interleukins on the development and course of distal neuropathy and diabetic foot syndrome in patients with type 1 and type 2 diabetes mellitus

A study of the effect of gene polymorphism of xenobiotic biotransformation system, matrix metalloproteinases and interleukins on the development and course of distal neuropathy and diabetic foot syndrome in patients with type 1 and type 2 diabetes mellitus

Studying polymorphic variants of the NAT2 gene (NAT25 and NAT27) in Nenets populations of Northern Siberia

The Changes of Rat Blood-Brain Barrier Permeability and Expression of Heat Shock Protein 70 after Infrasonic Damage

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Polymorphism of Genes of the System of Biotransformation of Xenobiotics in Patients With Occupational Allergic Dermatoses

Cited by 4 publications

References 2 publications

A study of the effect of gene polymorphism of xenobiotic biotransformation system, matrix metalloproteinases and interleukins on the development and course of distal neuropathy and diabetic foot syndrome in patients with type 1 and type 2 diabetes mellitus

A study of the effect of gene polymorphism of xenobiotic biotransformation system, matrix metalloproteinases and interleukins on the development and course of distal neuropathy and diabetic foot syndrome in patients with type 1 and type 2 diabetes mellitus

Studying polymorphic variants of the NAT2 gene (NAT2*5 and NAT2*7) in Nenets populations of Northern Siberia

The Changes of Rat Blood-Brain Barrier Permeability and Expression of Heat Shock Protein 70 after Infrasonic Damage

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Studying polymorphic variants of the NAT2 gene (NAT25 and NAT27) in Nenets populations of Northern Siberia