2005
DOI: 10.1158/1055-9965.epi-04-0826
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Polymorphism of the CD30 Promoter Microsatellite Repressive Element Is Associated with Development of Primary Cutaneous Lymphoproliferative Disorders

Abstract: Lymphomatoid papulosis is a preneoplastic cutaneous lymphoproliferative disorder characterized by overexpression of CD30, a member of the tumor necrosis factor receptor superfamily. CD30 signaling is known to have an effect on the growth and survival of lymphoid cells. Therefore, we hypothesized that the development of lymphomatoid papulosis and progression to an associated neoplasm such as cutaneous and systemic anaplastic large cell lymphoma may reflect an underlying genetic defect. In this study, we determi… Show more

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Cited by 16 publications
(11 citation statements)
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“…Perhaps genetic polymorphism of an immune response gene is an important factor. 69,70 Because the atypical cells of LyP-A have been reported to express Th2-associated markers CD30 and CCR4 71,72 and because messenger RNA for one or more Th2 cytokines is expressed in LyP-A infiltrates, 73 it is plausible that neutrophils and/or eosinophils are recruited into the dermal infiltrate in LyP-A by cytokines secreted by activated type A cells, whereas the atypical cerebriform lymphocytes of LyP-B may be low producers of Th2 cytokines. 74 The spontaneous disappearance of CD30+ cells in LyP-A lesions may be self-regulated by transforming growth factor-b secreted by the preneoplastic cells themselves, whereas cell-mediated host response against the preneoplastic cells is muted in a Th2-predominant microenvironment.…”
Section: Discussionmentioning
confidence: 99%
“…Perhaps genetic polymorphism of an immune response gene is an important factor. 69,70 Because the atypical cells of LyP-A have been reported to express Th2-associated markers CD30 and CCR4 71,72 and because messenger RNA for one or more Th2 cytokines is expressed in LyP-A infiltrates, 73 it is plausible that neutrophils and/or eosinophils are recruited into the dermal infiltrate in LyP-A by cytokines secreted by activated type A cells, whereas the atypical cerebriform lymphocytes of LyP-B may be low producers of Th2 cytokines. 74 The spontaneous disappearance of CD30+ cells in LyP-A lesions may be self-regulated by transforming growth factor-b secreted by the preneoplastic cells themselves, whereas cell-mediated host response against the preneoplastic cells is muted in a Th2-predominant microenvironment.…”
Section: Discussionmentioning
confidence: 99%
“…In the regulatory region, polymorphic STRs in the FLI1, ECE-1c and CD30 gene promoters have been associated with lupus [31], Alzheimer’s disease [32] and primary cutaneous lymphoproliferative disorders [33], respectively.…”
Section: Introductionmentioning
confidence: 99%
“…Our in vitro experiments support Meq’s previously demonstrated transcriptional regulation of CD30 [18], and, also show that the transcriptional profile generally follows genetic resistance and susceptibility to MD. A similar phenomenon has been observed in the CD30 over-expressing human cutaneous lymphoproliferative disease lymphomatoid papulosis [4,125]: allelic differences in the CD30 transcription are due to polymorphisms in the human CD30 microsatellite repressor element (located −1.2 kb and −336 bp of the CD30 promoter) and are associated with disease progression to lymphoma [125]. …”
Section: Discussionmentioning
confidence: 54%