Polymorphism of the IL1α, TNFα, IL6 genes and increased ability of neutrophils to form extracellular traps as a predisposing factor in the development of active pulmonary tuberculosis

Abstract

Objective. To assess the prevalence of IL1α (rs1800587), TNFα (rs1800629), IL6 (rs1800795) gene polymorphisms and the ability of neutrophils to form extracellular traps in patients with active pulmonary tuberculosis (TB). Material and methods. The study included 412 people, divided into 2 groups: main (n=184) – patients with active tuberculosis process who were treated in an inpatient setting at the Clinical Tuberculosis Dispensary (Omsk); control (n=228) – patients infected with Mycobacterium TB, without an active tuberculosis process, and without a history of TB. Results. Analysis of loci rs1800587 of the IL1α gene and rs1800795 of the IL6 gene did not reveal statistically significant differences when assessing susceptibility to the development of active forms of pulmonary TB. The A/A allelic variant of the rs1800629 locus of the TNFα gene was dominant among patients with active TB (p=0.28). An increased ability to form neutrophil extracellular traps was observed in patients with active pulmonary TB. Conclusion. Probably, the revealed increased ability of neutrophils to form extracellular traps is a consequence of the prevalence of TNFα gene polymorphism and the cytokine profile caused by it