Polymorphism of the ovine β3‐adrenergic receptor gene (ADRB3) and its association with wool mean staple strength and yield

Forrest, Rachel; Itenge-Mweza, T.O.; McKenzie, Grant; Zhou, Huitong; Frampton, Chris; Hickford, Jonathan G. H.

doi:10.1111/j.1365-2052.2009.01926.x

Cited by 16 publications

(7 citation statements)

References 12 publications

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“…The association analyses were based on the methods described by Byun et al (2010), Forrest et al (2009), Lin et al (2009), and Hickford et al (2010). After analyzing the associations between MUC1 genotypes and milk traits, the additive and co-dominance effects of the significant MUC1 genotypes were tested.…”

Section: Discussionmentioning

confidence: 99%

Associations between MUC1 gene polymorphism and resistance to mastitis, milk production and fertility traits in Murrah water buffaloes

Rosa

Moreira

Barbero

et al. 2020

Journal of Applied Animal Research

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MUC1 is a glycoprotein mucin expressed in apical cells of luminal tissues, such as mammary gland luminal cells, which the main function is protect the cell surface from the environment microorganisms. The aim of this study were to identify the polymorphism of MUC1 gene in Murrah breed and to analyze the association between molecular marker and somatic cell counting, milk yield, fat yield, fat percentage, protein yield, protein percentage, age at first calving and calving interval. A total of 179 primiparous Murrah buffaloes were genotyped by PCR technique. Milk-recording were performed periodically to determine fat and protein content and somatic cell count. Three alleles of different lengths were amplified and named allele 1, 2 and 3, respectively. The allele 2 was more frequent followed by allele 3. The MUC1 gene was highly associated with traits related to mastitis resistance and milk percentage. Also was demonstrated a mild association between MUC1 gene and milk protein synthesis and a moderate effect on reproductive trait. The MUC1 gene is polymorphic in water buffaloes of Murrah breed and might be a potential marker to marker-assisted selection for intramammary infection and some milk production traits.

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Section: Discussionmentioning

confidence: 99%

Associations between MUC1 gene polymorphism and resistance to mastitis, milk production and fertility traits in Murrah water buffaloes

Rosa

Moreira

Barbero

et al. 2020

Journal of Applied Animal Research

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“…Wool production and quality traits are polygenic and several of genes have been identified to be associated with wool production and quality trait. For example, it has been shown that the Desmoglein 4 ( DSG4 ) gene is associated with wool length and curvature [ 1 ], while the Beta-3 adrenergic receptor ( ADRB3 ) gene is associated with wool mean staple strength and yield [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization and Association of Ovine Dickkopf-1 Gene with Wool Production and Quality Traits in Chinese Merino

Rong

Yang

et al. 2017

Genes

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Dickkopf-1 (DKK1) is an inhibitor of canonical Wnt signaling pathway and regulates hair follicle morphogenesis and cycling. To investigate the potential involvement of DKK1 in wool production and quality traits, we characterized the genomic structure of ovine DKK1, performed polymorphism detection and association analysis of ovine DKK1 with wool production and quality traits in Chinese Merino. Our results showed that ovine DKK1 consists of four exons and three introns, which encodes a protein of 262 amino acids. The coding sequence of ovine DKK1 and its deduced amino acid sequence were highly conserved in mammals. Eleven single nucleotide polymorphisms (SNPs) were identified within the ovine DKK1 genomic region. Gene-wide association analysis showed that SNP5 was significantly associated with mean fiber diameter (MFD) in the B (selected for long wool fiber and high-quality wool), PW (selected for high reproductive capacity, high clean wool yield and high-quality wool) and U (selected for long wool fiber with good uniformity, high wool yield and lower fiber diameter) strains (p < 4.55 × 10−3 = 0.05/11). Single Nucleotide Polymorphisms wide association analysis showed that SNP8 was significantly associated with MFD in A strain and fleece weight in A (selected for large body size), PM (selected for large body size, high reproductive capacity and high meat yield) and SF (selected for mean fiber diameter less than 18 μm and wool fiber length between 5 and 9 cm) strains (p < 0.05), SNP9 was significantly associated with curvature in B and U strains (p < 0.05) and SNP10 was significantly associated with coefficient of variation of fiber diameter in A, PW and PM strains and standard deviation of fiber diameter in A and PM strains (p < 0.05). The haplotypes derived from these 11 identified SNPs were significantly associated with MFD (p < 0.05). In conclusion, our results suggest that DKK1 may be a major gene controlling wool production and quality traits, also the identified SNPs (SNPs5, 8, 9 and 10) might be used as potential molecular markers for improving sheep wool production and quality in sheep breeding.

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“…The limitations of QTL mapping using linkage analysis (LA) and/or linkage disequilibrium (LD), based on panels of low to moderate-density markers, have been well documented [2] , [3] . Only a few major genes, e.g., the KRTAP6 gene (keratin-associated protein 6) [4] , the PROP1 gene (PROP paired-like homeobox 1) [5] and ADRB3 (beta3-adrenergic receptor) [6] , have been associated with wool traits using QTL linkage analyses or candidate gene studies.…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Association Study for Wool Production Traits in a Chinese Merino Sheep Population

et al. 2014

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Genome-wide association studies (GWAS) provide a powerful approach for identifying quantitative trait loci without prior knowledge of location or function. To identify loci associated with wool production traits, we performed a genome-wide association study on a total of 765 Chinese Merino sheep (JunKen type) genotyped with 50 K single nucleotide polymorphisms (SNPs). In the present study, five wool production traits were examined: fiber diameter, fiber diameter coefficient of variation, fineness dispersion, staple length and crimp. We detected 28 genome-wide significant SNPs for fiber diameter, fiber diameter coefficient of variation, fineness dispersion, and crimp trait in the Chinese Merino sheep. About 43% of the significant SNP markers were located within known or predicted genes, including YWHAZ, KRTCAP3, TSPEAR, PIK3R4, KIF16B, PTPN3, GPRC5A, DDX47, TCF9, TPTE2, EPHA5 and NBEA genes. Our results not only confirm the results of previous reports, but also provide a suite of novel SNP markers and candidate genes associated with wool traits. Our findings will be useful for exploring the genetic control of wool traits in sheep.

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Polymorphism of the ovine β₃‐adrenergic receptor gene (ADRB3) and its association with wool mean staple strength and yield

Cited by 16 publications

References 12 publications

Associations between MUC1 gene polymorphism and resistance to mastitis, milk production and fertility traits in Murrah water buffaloes

Associations between MUC1 gene polymorphism and resistance to mastitis, milk production and fertility traits in Murrah water buffaloes

Structural Characterization and Association of Ovine Dickkopf-1 Gene with Wool Production and Quality Traits in Chinese Merino

Genome-Wide Association Study for Wool Production Traits in a Chinese Merino Sheep Population

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