Polymorphism of the Serotonin Transporter Gene and the Peripheral 5-Hydroxytryptamine in Obstructive Sleep Apnea: What Do We Know and What are We Looking for? A Systematic Review of the Literature

Maierean, Anca Diana; Bordea, Ioana Roxana; Sălăgean, Tudor; Hanna, Reem; Alexescu, Teodora; Chiș, Ana Florica; Todea, Doina Adina

doi:10.2147/nss.s278170

Cited by 9 publications

(8 citation statements)

References 82 publications

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“…In addition, researchers have also found that 5-HTT plays a crucial role in the study of limbic-frontal neural circuits ( 42 ); many studies have also focused on the activation of serotonin transporter ( 5 - HTTLPR ) polymorphisms in subregions in which the short (S) allele has been shown to reduce the transcriptional efficiency of the 5-HTT gene promoter ( 43 , 44 ). Studies have shown that the 5- HTTLPR gene polymorphism is associated with obstructive sleep apnea ( 45 ), female obsessive-compulsive disorder ( 46 ), postpartum depression ( 47 ), anorexia nervosa ( 48 ), and autism spectrum disorder ( 49 ) closely related. In addition, one study has demonstrated an increased risk of migraine in European women with the S allele ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation between 5-HTTLPR gene polymorphism and cognitive function of traumatic stress in Chinese Han children

Wu¹,

Lin²,

Wu³

et al. 2022

Transl Pediatr

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Background Post-traumatic stress disorder (PTSD) is a trauma-related psychological disorder with serious social and familial impacts. The involvement of 5-hydroxytryptamine transporter gene-linked polymorphic region ( 5-HTTLPR ) in numerous mental disorders has been documented. This study explored the correlation between 5-HTTLPR gene polymorphism and cognitive function in Chinese Han children with PTSD. Methods A total of 60 PTSD children treated from December 2019 to December 2021 were selected as study participants, with another 60 healthy children selected as controls. We assessed the cognitive function of participants using the Mini-Mental State Examination (MMSE). Additionally, the PTSD level was estimated by the Children’s Revised Impact of Event Scale (CRIES). The 5-HTTLPR gene polymorphism was detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The genotype and allele frequency were evaluated via case-control association analysis. Results Children in the PTSD group showed low MMSE scores and high CRIES scores. In terms of genotype, cases of LL, LS, and SS in PTSD children were 4 (6.67%), 20 (33.3%), and 36 (60.00%), and 18 (30.00%), 28 (46.67%), and 14 (23.33%) cases in healthy controls. In terms of allele gene frequency, incidences of L and S were 23.33% and 76.67% in PTSD children, respectively, and were 53.33% and 46.67% in healthy controls, respectively. Moreover, the CRIES and MMSE scores of LS and SS genotypes were evidently different from those of LL genotype in PTSD children. Conclusions Polymorphism of the 5-HTTLPR gene is correlated with cognitive dysfunction in Chinese Han children with PTSD.

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Section: Discussionmentioning

confidence: 99%

Correlation between 5-HTTLPR gene polymorphism and cognitive function of traumatic stress in Chinese Han children

Wu¹,

Lin²,

Wu³

et al. 2022

Transl Pediatr

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“…At the same time, the genetic predisposition of the [32,33]. A meta-analysis by Maierean et al [34] of studies investigating serotonin polymorphisms showed the course of OSA and dependence on serotonin genetic modification. Thus, the prevalence of the L/L genotype in men is higher, which explains the male predisposition to OSA.…”

Section: Discussionmentioning

confidence: 99%

“…The serotonin transporter gene polymorphism (SLC6A4) leads to changes in serotonin levels, which suggests that it is an important link in the pathogenesis of OSA [ 32 , 33 ]. A meta-analysis by Maierean et al [ 34 ] of studies investigating serotonin polymorphisms showed the course of OSA and dependence on serotonin genetic modification.…”

Section: Discussionmentioning

confidence: 99%

Sleep Apnea and Serum Serotonin Level Pre- and Post-PAP Therapy: A Preliminary Study

et al. 2021

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Introduction:The high prevalence of obstructive sleep apnea (OSA), which impairs quality of life for numerous patients and leads to various OSA complications, has contributed to the continued interest in this disorder. The role of serotonin (5-HT) in many physiological processes, studies on its connection with the circadian system, and relationship to changes in sleep architecture are insufficient to assess the interaction of this neurotransmitter with nocturnal hypoxia. The aim of this study was to determine changes in sleep patterns and serum serotonin levels before and after positive airway pressure (PAP) therapy in patients with OSA. Methods: The study involved 30 OSA patients (27 men and 3 women) who were treated with PAP for 3 months. Polysomnography using the GRASS TELEFACTOR (USA) and blood collection were conducted before and after PAP courses. Determination of serum serotonin was performed by high-performance liquid chromatography (HPLC). PAP therapy was performed using an automatic Prisma 20A (Germany) continuous positive airway pressure (CPAP) device. Results: The use of PAP for 3 months revealed a significant improvement as measured by sleep data and serotonin levels (before: apnea index [AI] 17.2 eV/h, after: 2.4 eV/h p = 0.001; SpO 2 \ 90% -45.7 min vs. 6.2 min p = 0.001; serotonin 20.3 ng/mL vs. 26.03 ng/mL p = 0.036]. Conclusion: Our results demonstrate an improvement in sleep patterns. There was an increase in serum serotonin levels in OSA patients following PAP therapy, which could be an effect of intermittent hypoxia decline, and could be used as criteria for the effectiveness of PAP and an improvement in sleep quality.

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“…Furthermore, studies involving monozygotic twins and siblings/children of persons with OSA have shown an up-to 50% increased odds of developing OSA compared to the general population (Ferini-Strambi et al 1995;Friberg et al 2009;Lundkvist et al 2012;Szily et al 2019). Additionally, numerous genetic studies (Palmer et al 2003;Patel et al 2007;Khalyfa et al 2008;Gozal et al 2007;Kalra et al 2008;Farias Tempaku et al 2020;Maierean et al 2021;Kerz et al 2021;Patel et al 2012) have identified several novel genetic loci associated with a sleep apnea phenotype suggesting around two-fifth (Casale et al 2009;Yue et al 2008;Yue et al 2005) of the OSA variance is attributable to genetic factors.…”

Section: Discussionmentioning

confidence: 99%

Obstructive sleep apnea and associated factors among hypertensive patients attending a tertiary cardiac center in Tanzania: a comparative cross-sectional study

Pallangyo¹,

Mgopa

Mkojera³

et al. 2021

Sleep Science Practice

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Background There is mounting evidence for a reciprocal yet bidirectional association between sleep-disordered breathing and hypertension. Obstructive sleep apnea (OSA), a common cause of systemic hypertension is an independent risk factor for hypertension-related cardiovascular morbidity and mortality. In this comparative hospital-based cross-sectional study, we sought to explore the burden of obstructive sleep apnea and its associated risk factors among hypertensive patients attending Jakaya Kikwete Cardiac Institute. Methodology A total of 1974 individuals (i.e. 1289 hypertensive and 685 normotensives) were consecutively enrolled in this study. The Berlin questionnaire and Epworth Sleepiness Scale were utilized in the assessment of OSA and excessive daytime sleepiness (EDS) respectively. Logistic regression analyses were employed in the determination of associated factors for OSA. Results The mean age was 53.4 years and females constituted the large majority (60.4%) of participants. About three quarters (74.1%) of participants had excess body weight, 11.6% had diabetes, 8.0% had asthma and 18.6% had history of recurrent nasal congestion. Positive family history of snoring was reported by 43.1% of participants and 36.9% had a personal history of snoring. Persons with hypertension displayed a higher frequency (42.1%) of OSA compared to their normotensive counterparts (11.8%), p < 0.001. Multivariate logistic regression analyses revealed hypertension (OR 5.1, 95% CI 3.2-8.2, p < 0.001), diabetes mellitus (OR 2.2, 95% CI 1.3-3.5, p < 0.01), chronic nasal congestion (OR 1.6, 95% CI 1.1-2.5, p = 0.01), obesity (OR 2.4, 95% CI 1.8-3.3, p < 0.001), increased neck circumference (OR 2.7, 95% CI 1.2-6.4, p = 0.02), family history of snoring (OR 5.5, 95% CI 4.0-7.5, p < 0.001), and working > 8 h/24 h (OR 0.6, 95% CI 0.4-1.0, p = 0.03) to have an independent association for OSA. Furthermore, participants with hypertension displayed superior odds for OSA compared to their normotensive counterparts across all subgroup analyses. Conclusion OSA is considerably common among patients with hypertension in a tertiary health care setting in Tanzania. Positive family history of snoring was the strongest associated factor; however, excess body weight proved to be the strongest modifiable risk factor. In view of its pervasiveness, OSA should be an integral part of the medical evaluation in hypertensive individuals.

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Polymorphism of the Serotonin Transporter Gene and the Peripheral 5-Hydroxytryptamine in Obstructive Sleep Apnea: What Do We Know and What are We Looking for? A Systematic Review of the Literature

Cited by 9 publications

References 82 publications

Correlation between 5-HTTLPR gene polymorphism and cognitive function of traumatic stress in Chinese Han children

Correlation between 5-HTTLPR gene polymorphism and cognitive function of traumatic stress in Chinese Han children

Sleep Apnea and Serum Serotonin Level Pre- and Post-PAP Therapy: A Preliminary Study

Obstructive sleep apnea and associated factors among hypertensive patients attending a tertiary cardiac center in Tanzania: a comparative cross-sectional study

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