Polymorphism of the STAT5A and MYF-5 genes in Anatolian water buffalo

Daldaban, Fadime; Arslan, Korhan; Aksel, Esma Gamze; Akyüz, Bilal

doi:10.3906/vet-1904-30

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Базуючись на проведених останнім часом закордонних дослідженнях, перспективними для досліджень у контексті зв'язку з параметрами м'ясної та молочної продуктивності великої рогатої худоби вважаються гени рецептору гормону росту (GHR) та міогенного фактору 5 (MYF5) [1,2]. На жаль, на сьогодні даних щодо особливостей поліморфізму зазначених генів (мається на увазі певні мутації у контексті цієї роботи -AluI-поліморфізм у промоторному фрагменті GHR та TaqI-поліморфізм у другому інтроні MYF5) та їхнього зв'язку з продуктивними якостями стад та популяцій великої рогатої худоби вітчизняної селекції, практично немає.…”

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Polymorphism of Growth Hormone Receptor Gene and Myogenic Factor 5 Gene in Dairy Cattle Populations

Alshamaileh

Kulibaba

Liashenko

et al. 2021

STBIAS

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Investigations of the genetic structure features of the populations of Ukrainian Black-and-White and Red-and-White dairy breeds by polymorphism of growth hormone receptor (GHR) and myogenic factor 5 (MYF5) genes were carried out. AluI-polymorphism in the promoter fragment of the GHR gene and TaqI-polymorphism in the second intron of the MYF5 gene was detected using polymerase chain reaction and restriction analysis (PCR-RFLP). According to the research results, it was shown that the growth hormone receptor and myogenic factor 5 genes in the populations of Ukrainian Black-and-White and Red-and-White dairy breeds are polymorphic. In the population of the Ukrainian Black-and-White dairy breed at the GHR locus, the frequency of the AluI+ allele was 0.61; allele AluI- – 0.39; at the MYF5 locus, the TaqI+ allele frequency was 0.65; allele Taq- – 0.35, respectively. In the population of the Ukrainian Red-and-White dairy breed at the GHR locus, the frequency of the AluI+ allele was 0.54; allele AluI- – 0.46; at the MYF5 locus, the TaqI+ allele frequency was 0.64; allele Taq- – 0.36, respectively. Both experimental populations for GHR and MYF5 loci are in a genetic equilibrium state according to Hardy-Weinberg, which indicates the absence of microevolutionary changes in the process of their reproduction. There were no significant fluctuations in the genetic structure according to the revealed features of the genotype and allele frequencies distribution. The breeding work that is carried out on both populations does not affect marker alleles (which are described in the work), which is reflected in the features of the genetic-population structure of the experimental groups and their equilibrium state. The features of the distribution of individuals with different genotypes by GHR and MYF5 loci in the populations of both breeds make it possible to carry out further studies to determine the relationship between the identified allelic variants of polymorphic loci with parameters of animal productivity.

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Polymorphism of Growth Hormone Receptor Gene and Myogenic Factor 5 Gene in Dairy Cattle Populations

Alshamaileh

Kulibaba

Liashenko

et al. 2021

STBIAS

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Single nucleotide polymorphism in STAT5A could not endorse variation in milk production traits in Indian bovine population

Sudhakar

Aranganoor

Ramasamy

et al. 2021

AVet

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The Signal Transducer and Activator of Transcription 5A (STAT5A) gene involved in activating the transcription of milk protein genes was predicted to be influencing milk production traits. The present study was undertaken to investigate the suitability of the polymorphism of STAT5A as a marker for milk traits in Ongole, crossbred cattle and Murrah buffaloes from Southern India. Blood samples (n = 502) for DNA isolation and milk samples (n = 222) from different genetic groups were collected from various farms. The gene variants upon polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) on the exon 7 region of STAT5A were subjected to GLM analysis to evaluate their association with milk production traits. The frequencies of C and T alleles at the STAT5A/AvaI locus were 0.98 and 0.02 (Jersey crossbred), 0.94 and 0.06 [Holstein-Friesian (HF) crossbred], 0.97 and 0.03 (Ongole). T allele was not observed in Murrah buffaloes. The least squares mean lactation milk yield of CC and CT genotypes of STAT5A were 2,096.90 ± 48.63 and 2,294.41 ± 215.85 kg in Jersey crossbred, 2,312.92 ± 91.01 and 2,392.82 ± 207.66 kg in HF crossbred and 528.40 ± 22.10 and 396.37 ± 76.17 kg in Ongole cattle, respectively. The milk fat content of the CC genotype was higher (P > 0.05) in Jersey crossbred cattle. The CT genotypes of Ongole and HF crossbred cattle recorded a higher fat per cent than the CC genotypes. Significant associations were not observed in support of STAT5A as a marker for milk production traits in either Ongole or crossbred cattle of indicine admixture and no reason could be found to consider this locus as universal markers for milk production traits in indicine cattle and buffaloes. Considering the monomorphic nature of the gene in buffaloes and their higher milk fat content as compared to bovine milk, much remains to be explored regarding the underlying differences across the bovine and the bubaline species.

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Polymorphism of the STAT5A and MYF-5 genes in Anatolian water buffalo

Cited by 2 publications

References 30 publications

Polymorphism of Growth Hormone Receptor Gene and Myogenic Factor 5 Gene in Dairy Cattle Populations

Polymorphism of Growth Hormone Receptor Gene and Myogenic Factor 5 Gene in Dairy Cattle Populations

Single nucleotide polymorphism in STAT5A could not endorse variation in milk production traits in Indian bovine population

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