Polymorphism of vascular endothelial growth factor –2578C/A with cancer risk: evidence from 11263 subjects

Cao, Chao; Ying, Tao; Jingjing, Fang; Sun, Shifang; Lv, Dan; Chen, Zhong-Bo; Ma, Hongying; Yu, Yiming; Ding, Qunli; Shu, Lihua; Deng, Zaichun

doi:10.1007/s12032-010-9613-1

Cited by 18 publications

(10 citation statements)

References 23 publications

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“…Specifically, we found that women with the VEGFA rs833070 TT genotype and/or increasing copies of the FLT1 ( VEGFR1 ) rs9551471 A allele, had increasing risks of breast cancer in a dose-response manner. These findings are consistent with recent meta-analyses that reported no significant associations between VEGFA -2578 C/A ( rs699947 ), -460C/T ( rs833061 ), and +936 C/T ( rs3025039 ) variants and breast cancer risk (31-35). To date, no genome wide association studies (GWAS) of breast cancer have detected significant associations between VEGF family variants and breast cancer risk.…”

Section: Discussionsupporting

confidence: 92%

Genetic Variation in VEGF Family Genes and Breast Cancer Risk: A Report from the Shanghai Breast Cancer Genetics Study

Beeghly–Fadiel

Shu

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background In addition to mediating aspects of physiological and pathological angiogenesis, the vascular endothelial growth factor (VEGF) family also contributes to carcinogenesis. Methods We comprehensively characterized genetic variation across four VEGF family genes and evaluated associations with breast cancer risk with odds ratios and 95% confidence intervals (OR, 95% CI) for participants of the two-stage case-control Shanghai Breast Cancer Genetics Study (SBCGS). Stage 1 evaluated 200 single nucleotide polymorphisms (SNPs) across two VEGF ligands (VEGFA and VEGFC) and two VEGF receptors (FLT1/VEGFR1 and KDR/VEGFR2) among 2,079 cases and 2,148 controls. Five SNPs with promising associations were assessed in Stage 2 among 4,419 cases and 1,851 controls. Results Two SNPs were consistently associated with breast cancer risk across our two study stages, and significant in combined analyses. Compared to FLT1 rs9551471 major allele homozygotes (AA), reduced risks were associated with AG (OR=0.92, 95% CI: 0.84-1.00) and GG (OR=0.78, 95% CI: 0.64-0.95) genotypes (p-value for trend = 0.005). Compared to VEGFA rs833070 major allele carriers (CC or CT), increased risk was associated with TT genotypes (OR=1.26, 95% CI: 1.05-1.52, p-value = 0.016). Conclusion Results from our study indicate that common genetic variation in VEGFA and FLT1 (VEGFR1) may contribute to breast cancer susceptibility. Impact Our findings provide clues for future studies on VEGF family genes in relation to cancer susceptibility and survival.

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Section: Discussionsupporting

confidence: 92%

Genetic Variation in VEGF Family Genes and Breast Cancer Risk: A Report from the Shanghai Breast Cancer Genetics Study

Beeghly–Fadiel

Shu

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…However, the reasons for heterogeneity in the analysis of −1082A/G were unclear. It may be due to other factors, including the selection of methods, definition of cases, and sample sizes [19]. We further performed a sensitivity analysis and found the studies by Kung et al [8] and Kolla et al [13] were the main origin of heterogeneity for −1082A/G.…”

Section: Discussionmentioning

confidence: 94%

Interleukin-10 −592C/A, −819C/T and −1082A/G Polymorphisms with Risk of Type 2 Diabetes Mellitus: A HuGE Review and Meta-analysis

et al. 2013

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BackgroundSeveral studies have been conducted in recent years to evaluate the risk of type 2 diabetes mellitus (T2DM) and polymorphisms of interleukin (IL)-10. However, the results remain conflicting rather than conclusive. This meta-analysis aimed to summarize the current evidence from case-control studies that evaluated this association.MethodsWe carried out a search in Medline, EMBASE, and the Chinese National Knowledge Infrastructure (CNKI) database for relevant studies. Data were extracted using a standardized form and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the association.Results10 studies were included in our meta-analysis and systemic review. Our meta-analysis indicated that IL-10 −1082A/G polymorphism was associated with the risk of T2DM (GA vs. AA: OR = 1.21, 95% CI = 1.03–1.14; GA/GG vs. AA: OR = 1.22, 95% CI = 1.05–1.41), whereas there was no association between IL-10 −592C/A (CC/CA vs. AA: OR = 1.07, 95% CI = 0.59–1.93) or -819C/T (CC/CT vs. TT: OR = 0.93, 95% CI = 0.49–1.75) polymorphism and T2DM risk was found in our study.ConclusionsThis meta-analysis provides strong evidence that IL-10 −1082A/G polymorphism associated with risk of T2DM. However, no association of the IL-10 −592C/A or −819C/T polymorphism with T2DM risk was found. Additional well-designed large studies were required for the validation of our results.

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“…Allele frequency might reflect the natural selection pressures or a balance by other related functional genetic variants and environmental exposures (37,38). Thus, the association between ACE polymorphism and other ethnic groups needed further investigation.…”

Section: Discussionmentioning

confidence: 99%

Association between Angiotensin-Converting Enzyme I/D Polymorphism and Asthma Risk: A Meta-Analysis Involving 11,897 Subjects

et al. 2012

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Polymorphism of vascular endothelial growth factor –2578C/A with cancer risk: evidence from 11263 subjects

Cited by 18 publications

References 23 publications

Genetic Variation in VEGF Family Genes and Breast Cancer Risk: A Report from the Shanghai Breast Cancer Genetics Study

Genetic Variation in VEGF Family Genes and Breast Cancer Risk: A Report from the Shanghai Breast Cancer Genetics Study

Interleukin-10 −592C/A, −819C/T and −1082A/G Polymorphisms with Risk of Type 2 Diabetes Mellitus: A HuGE Review and Meta-analysis

Association between Angiotensin-Converting Enzyme I/D Polymorphism and Asthma Risk: A Meta-Analysis Involving 11,897 Subjects

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