Polymorphism of XRCC7 Gene and Risk of Glioma: A Prospective Case–Control Study

Abstract

Objective The aim of this study is to determine association between polymorphism of XRCC7 gene and glioma. Materials and Methods A case–control study was designed to analyze the prevalence of the various XRCC7 genotypes in 30 cases of histologically proven glioma and 30 age- and sex matched controls. Result There is significantly higher prevalence of the GT and the TT genotypes of XRCC7 gene in cases of glioma as compared with control. The prevalence was significantly pronounced in two subgroups–middle aged and male gender. The presence of the XRCC7 GT or TT genotype conferred a significantly higher risk of developing glioma (odds ratio: 13.021,2.114–80.213). Conclusion The presence of the T allele in XRCC7 polymorphism may increase the susceptibility to glioma.