Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review

Abstract

Cardiovascular disease (CVD) is one of the leading causes of mortality in hemodialysis (HD) subjects. In addition to the traditional risk factors that are common in these individuals, genetic factors are also involved, with emphasis on single nucleotide polymorphs (SNPs). In this context, the present study aims to systematically review the studies that investigated the polymorphisms associated with cardiovascular risk in this population. In general, the SNPs present in HD individuals are those of genes related to inflammation, oxidative stress and vascular calcification, also able of interfering in the cardiovascular risk of this population. In addition, polymorphisms in genes related to recognized risk factors for CVD, such as dyslipidemia, arterial hypertension and left ventricular hypertrophy, also influence cardiovascular morbidity and mortality.

Identification of ethnogenetic differences in genetic markers in the clinical course and damage to target organs in arterial hypertension in Russians and Buryats

“…Некоторые исследователи описывают такую связь только в некоторых популяциях и этнических группах больных. Один из проведенных крупных метаанализов на большой выборке европейской популяции (6 923 человека) позволил говорить лишь о повышении риска АГ на 10 % у носителей аллелей DD гена АCE [18]. В исследованиях монголоидной расы было показано, что частота генотипа DD и аллеля D у гипертоников (36,2 и 63,8 % соответственно) значительно выше, чем у пациентов с нормальным уровнем АД (29,8 и 57,2 % соответственно, p < 0,05) [19] Необходимость исследований генетических маркеров заключается в разработке более совершенных методов прогнозирования риска сердечно-сосудистых заболеваний.…”

Polymorphisms in the 5’-UTR region of IL-10RA gene are associated with chronic kidney disease

“…21 Polymorphisms of cytokine genes may influence gene transcription and cytokine secretion and therapy modulate the risk of progression of renal and cardiovascular diseases. 18 Association between IL10, IL10RA, and IL10RB polymorphism and several diseases have been reported. Polymorphism of IL10, IL10RA, and IL10RB genes may be contributed to the hypertension in the risk of ischemic stroke.…”

“…[14][15][16] In CKD patients, there are no specific symptoms in early stages and symptoms are non-specific even in later Recently inflammation is considered one of important factors related to CKD progression and outcome. 18 Amdur RL et al revealed inflammatory markers such as fibrinogen and TNF-α were associated with rapid loss of kidney function in patients with CKD in large cohort study. 19 Another large cross-sectional study showed that SNPs of IL-4 and IL-6 were associated with kidney function and CKD prevalence in Japanese population.…”

Possíveis Efeitos Climáticos No Agravo De Hipertensão Arterial Sistêmica

“…Essa adaptação da musculatura lisa do endotélio vascular pode ser tanto relacionada ao aumento da produção da matriz extracelular (MEC), em casos de hipertensão benigna, caracterizando a arteriosclerose hialina, ou pode apresentar espessamentos laminares concêntricos, caracterizando a arteriosclerose hiperplásica, característica da hipertensão grave (HARRISON et al, 2021e OLIVEIRA et al, 2021. É necessário enfatizar, igualmente, que a HAS pode ter fonte genética por estresse oxidativo e o ritmo cardíaco, por exemplo (BALBINO, 2018).…”

“…único (SNP)(BALBINO, 2018). Desta forma, o genoma humano foi mapeado e a partir disso foi criado o Genetic Risk Score, uma pontuação baseada em uma série de polimorfismos de gene único, que estão relacionados com o desenvolvimento de comorbidades como a de HAS é a IL-10.…”