Polymorphism rs368234815 of interferon-λ4 gene and generation of antibodies to hepatitis B virus surface antigen in extracorporeal dialysis patients

Grzegorzewska, Alicja E.; Świderska, Monika; Marcinkowski, Wojciech; Mostowska, Adrianna; Jagodzińśki, Paweł P.

doi:10.1080/14760584.2020.1745637

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Possible explanations include immune cell disturbances [24][25][26]. Also gene variations in vaccine response genes (e.g., Interferon-λ4 polymorphisms) were shown to influence Hepatitis B vaccine response in dialysis patients [27].…”

Section: Discussionmentioning

confidence: 99%

Hemodialysis Patients Show a Highly Diminished Antibody Response after COVID-19 mRNA Vaccination Compared to Healthy Controls

Simon¹,

Rubey²,

Treipl

et al. 2021

Preprint

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1. Abstract 1.1 Background and Objectives Hemodialysis patients are prone to infection with SARS-COV2 and show a high probability of a severe course of disease and high mortality when infected. In many countries hemodialysis patients are prioritised in vaccination programs to protect this vulnerable community. However, no hemodialysis patients were included in efficacy trials of SARS CoV-2 vaccines and therefore efficacy and safety data for this patient group are lacking. These data would be critical, since hemodialysis patients showed decreased responses against various other vaccines and this could mean decreased response to SARS CoV-2 vaccines. 1.2 Design, setting, participants, and measurements We conducted a prospective cohort study consisting of a group of 81 hemodialysis patients and 80 healthy controls who were vaccinated with mRNA vaccine BNT162b2 (BionTech/Pfizer, 2 doses with an interval of 21 days). Anti-SARS-COV-2 S antibody response in all participants was measured 21 days after the second dose. The groups were compared with univariate quantile regressions and a multiple analysis. Adverse events (AEs) of the vaccination were assessed with a standardized questionnaire. We also performed a correlation of HBs-Antibody response with the SARS-COV-2 antibody response in the hemodialysis patients. 1.3 Results Dialysis patients had significantly lower Anti-SARS-COV-2 S antibody titres than healthy control patients 21 days after vaccination with BNT162b2 (median dialysis Patients 171 U/ml versus median controls 2500 U/ml). Age also had a significant but less pronounced influence on antibody titres. Dialysis patients showed less AEs than the control group. No significant correlation was found for Hepatitis B vaccine antibody response and SARS CoV-2 vaccine antibody response. 1.4 Conclusions Hemodialysis patients exhibit highly diminished SARS-COV-2 S antibody titres compared to a cohort of controls. Therefore these patients could be much less protected by SARS CoV-2 mRNA vaccination than expected. Alternative vaccination schemes must be considered and preventive measures must be maintained after vaccination.

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Section: Discussionmentioning

confidence: 99%

Hemodialysis Patients Show a Highly Diminished Antibody Response after COVID-19 mRNA Vaccination Compared to Healthy Controls

Simon¹,

Rubey²,

Treipl

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Many studies analyzed the role of genetic polymorphisms of the IFN genes in HBV infection ( Ben Selma et al, 2021 ; Boglione et al, 2014 ). The ∆G allele of (merged into ) was the risk factor for anti-HBs positive HBV patients, and the genotype ∆G/∆G decreased the responsiveness of HBV vaccination ( Grzegorzewska et al, 2020 ). Furthermore, the genotype of rs12979860 could modulate the HBV cccDNA levels located at the IFNL3 and IFNL4 genes ( Chihab et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…The viral clearance of HCV patients treated with pegylated-IFN-α/ribavirin could be influenced by the genetic polymorphisms of the IFNL4 gene ( O’Brien et al, 2015 ). Similarly, the genetic polymorphisms in the IFNL4 gene were also associated with the viral load of HBV patients and protect individuals from HBV infection ( Chihab et al, 2021 ; Grzegorzewska et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China

Zheng

Shen

Xia

et al. 2022

PeerJ

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Hepatitis B virus (HBV) infection causes Hepatitis B, which is one of the most common causes of hepatocellular carcinoma (HCC). The single nucleotide polymorphisms (SNPs) of the host immune genes could impact HBV infection, viral clearance, and treatment effect. However, the contradictory roles of several studies suggest further analysis of various populations. The whole blood and biochemical indexes of 448 HBV patients and matched controls were collected from the Yunnan population to investigate the genetic roles of IFNL4 and the downstream genes (MxA and MxB). The genotypes, alleles, and haplotypes frequencies of the seven SNPs (rs11322783, rs117648444, rs2071430, rs17000900, rs9982944, rs408825, and rs2838029) from the HBV patients and controls were analyzed. However, no association was identified between the SNPs and HBV infection. Then, biochemical index levels were evaluated among the HBV patients with different genotypes of the seven SNPs. The results indicated that the liver function index levels (including alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), and albumin (ALB)) were influenced by the genotypes of the SNPs in HBV patients. Moreover, when the HBV patients were divided into HBsAg-positive and -negative groups, the association between the SNP genotypes and the biochemical indexes still existed. In addition, although the genetic polymorphisms in the IFNL4, MxA, and MxB genes were not significantly associated with HBV infection in the Yunnan population, these genes could indirectly influence disease progression by associating with the biochemical index levels of Yunnan HBV patients.

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Vaccinomics: A scoping review

Dudley

Gerber

et al. 2023

Vaccine

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Polymorphism rs368234815 of interferon-λ4 gene and generation of antibodies to hepatitis B virus surface antigen in extracorporeal dialysis patients

Cited by 5 publications

References 24 publications

Hemodialysis Patients Show a Highly Diminished Antibody Response after COVID-19 mRNA Vaccination Compared to Healthy Controls

Hemodialysis Patients Show a Highly Diminished Antibody Response after COVID-19 mRNA Vaccination Compared to Healthy Controls

Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China

Vaccinomics: A scoping review

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