Polymorphisms and AR: A Systematic Review and Meta-Analyses

Abstract

Background: Allergic rhinitis (AR) is an especially common disorder associated with both environmental and genetic factors, and a lot of researchers have attempted to find polymorphisms which predisposed to the disease. We conducted a meta-analysis of the most frequently researched polymorphisms to find those genes which may be susceptible to AR and then may be of value in diagnosis.Methods: Pubmed and China National Knowledge Infrastructure (CNKI) databases were searched to screen out eligible studies focusing on the correlation between polymorphisms and AR susceptibility, and then polymorphisms cited in at least 3 studies were selected.Results: The 142 papers originally selected cited 78 genes. Twelve genes (coinciding with 23 polymorphisms) were reported in more than three papers. Twenty-three polymorphisms were involved in the meta-analysis. Among the 23 polymorphisms, only 4 were found to be related to the risk of AR: IL-13 rs20541, CTLA-4 rs11571302, IL-4R RS1801275 and ACE (I/D). The remaining 19 of the 23 polymorphisms were not associated with AR.Conclusion: We found polymorphisms that could be used for AR diagnosing and those that were unrelated to AR. This may be the first step in detecting polymorphic combinations susceptible to AR (IL-13 RS20541, CTLA-4 RS11571302, IL-4R RS1801275 and ACE (I/D). In addition, our results may improve AR diagnosis and contribute to the intensive study of AR.

Genetic association of beta-lactams-induced hypersensitivity reactions: A systematic review of genome-wide evidence and meta-analysis of candidate genes

“…Interestingly, for rs20541, we found that this polymorphism increases the risk of BL-induced hypersensitivity. Like other studies, this polymorphism demonstrated promising genetic effect to various allergic diseases including asthma, 72 allergic rhinitis, 68 atopic dermatitis, and even with alternation of total serum IgE levels. 73 According to dbSNP, this risk allele A accounts for 0.21 of total allele frequency in global population (from 367 982 sample size).…”

“…Since IL4R and IL13 play major roles in IgE-mediated activation for allergy, they have been studied widely in different populations since 2004 and have become a promising therapeutic target for allergic reactions in recent years. 67 In particular, rs1801275 polymorphism has been reported as a risk factor for allergic rhinitis 68 and cancer susceptibility, 69 where some other evidence found controversial results. 70 , 71 In this study, we revealed a protective effect of rs1801275 polymorphism in decreasing the risk of BL-induced hypersensitivity.…”