Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India

Nath, Nidhi; Mishra, Prajna; Panda, Aditya K.; Mishra, Rajakishore

doi:10.1016/j.intimp.2020.106925

Cited by 18 publications

(9 citation statements)

References 51 publications

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“…The current meta-analysis data showed that TLR9 rs352140 was not associated with susceptibility to cervical cancer. Nath et al, (2020) in a study showed that TLR4/9 polymorphisms are associated with increased HPV16/18 infection susceptibility and cervical squamous cell carcinoma risk among the women of Jharkhand state. In another study in India showed the TLR4 and TLR9 polymorphisms and haplotypes with hrHPV infection and cervical cancer risk (Pandey et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma

Parsaeian

Asadian

Karimi-Zarchi

et al. 2021

Asian Pac J Cancer Prev

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Background:In spite of substantial declines in both incidence and mortality rates in the past 50 years, cervical cancer remains one of the leading causes of cancer associated mortality among women globally. We performed this meta-analysis to explore the role of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629 and TLR9 rs352140 polymorphism with susceptibility to cervical carcinoma. Methods: The search databases include PubMed, SciELO, MedRxiv, Web of Science, Scopus, Cochrane Library, China National Knowledge Infrastructure, and China Biology Medicine disc up to 30 June 2021. The language is limited to English and Chinese. The comparison between the polymorphisms and cervical cancer was assessed using pooled odds ratio (OR) and 95% confidence interval (CI). The data are statistically analyzed by Comprehensive Meta-Analysis (CMA) 2.0 software. Results: A total of 59 studies including seven studies with 1,112 cases and 1,233 controls on XRCC3 rs861539, 14 studies with 2,694 cases and 3349 controls MTHFR rs1801133, four studies with 1,121 cases and 1,109 controls on IL-12B rs3212227, seven studies with 1,452 cases and 2,186 controls on IL-6 rs1800795, 20 studies with 4,781 cases and 4909 controls on TNF-α rs1800629, and seven studies with 1743 cases and 2292 controls on TLR9 rs352140 were included. There was a significant association between XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 polymorphisms and an increased risk of cervical carcinoma in overall population. However, the MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms were not associated. Conclusion: The pooled analysis showed that XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 were associated with cervical carcinoma susceptibility, but not MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms.

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Section: Discussionmentioning

confidence: 99%

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma

Parsaeian

Asadian

Karimi-Zarchi

et al. 2021

Asian Pac J Cancer Prev

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“…A previous study has suggested that tumor‐related genes play an important role in HR‐HPV infection progressing into cervical cancer 16 . Subsequent studies have revealed that TLR2/4/9 expression shows positive correlations with progression 17–19 . Altoos et al 20 demonstrated that the expression level of NF‐κBp65 is associated with poor clinical outcomes in patients with locally advanced cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

“…16 Subsequent studies have revealed that TLR2/4/ 9 expression shows positive correlations with progression. [17][18][19] Altoos et al 20 demonstrated that the expression level of NF-κBp65 is associated with poor clinical outcomes in patients with locally advanced cervical cancer. Another study revealed that the expression of C-myc and POU5F1B is higher in CIN grade 2 or worse (CIN2+) than in normal patients or CIN1.…”

Section: Introductionmentioning

confidence: 99%

Prevotella as the hub of the cervicovaginal microbiota affects the occurrence of persistent human papillomavirus infection and cervical lesions in women of childbearing age via host NF‐κB/C‐myc

Dong

Huang

Cai

et al. 2022

Journal of Medical Virology

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There is evidence that coinfection of cervicovaginal high-risk human papillomavirus (HR-HPV) and bacteria is common in women of childbearing age. However, the relationship between bacterial vaginosis (BV) and persistent HR-HPV infection in women of childbearing age and the underlying mechanisms remain unclear. In this study, we determined whether BV affects persistent HR-HPV infection in women aged 20-45 years and explored the possible mechanisms of their interactions. From January 1 to April 30, 2020, we recruited women aged 20-45 years with and without BV at a ratio of 1:2 from Fujian Maternity and Child Health Hospital. All women were followed up at 0, 12, and 24 months. A BV assay, HR-HPV genotyping and cervical cytology were performed at each follow-up. At 0 months, additional vaginal secretions and cervical exfoliated cells were collected for 16S ribosomal RNA sequencing, bacterial metabolite determination, and POU5F1B, C-myc, TLR4, NF-κB, and hTERT quantification. A total of 920 women were included. The

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“…India has the largest burden of cervical cancer globally, with an annual incidence of 123,000 cases 2 . Infection with human papillomavirus (HPV) along with poor hygiene, use of oral contraceptives and immunosuppressant medications, and oxidative stress due to excessive generation of reactive oxygen species contribute to an enhanced risk of CSCC 3,4 . HPV16/18 is responsible for CSCC in most cases.…”

Section: Introductionmentioning

confidence: 99%

“…2 Infection with human papillomavirus (HPV) along with poor hygiene, use of oral contraceptives and immunosuppressant medications, and oxidative stress due to excessive generation of reactive oxygen species contribute to an enhanced risk of CSCC. 3,4 HPV16/18 is responsible for CSCC in most cases. Currently available prophylactic vaccines against a subset of highrisk HPVs recommended by the WHO reduce the disease burden.…”

Section: Introductionmentioning

confidence: 99%

Glycogen synthase kinase‐3β inactivation promotes cervical cancer progression, invasion, and drug resistance

Nath

Rana

Nagini

et al. 2021

Biotech and App Biochem

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Human papillomavirus (HPV) infection‐dependent cervical cancer is one of the most common gynecological cancers and often becomes aggressive, with rapid proliferation, invasion/migration, and drug resistance. Here, 135 fresh human cervical squamous cell carcinoma (CSCC) tissue specimens, comprising 21 adjacent normal (AN), 30 cervical intraepithelial neoplasia (CIN1–3), 45 CSCC, and 39 drugs (chemo‐radiation)‐resistant cervical tumor (DRCT) tissues were included. HPV‐positive (HeLa, SiHa), HPV‐negative (C33A), and cisplatin‐resistant (CisR–HeLa/–SiHa/–C33A) cell lines were used for in vitro studies. HPV16/18 oncoproteins E6/E7, pERK1/2, and glycogen synthase kinase‐3 (GSK3) and the matrix metalloproteinases (MMPs) MMP‐9/‐2 were assessed using immunohistochemistry, WB, and gelatin zymography. HPV16/18 infection was observed in 16.7% of the CIN1‐3, 77.8% of the CSCC, and 89.7% of DRCT samples. Total and inactive GSK3β expressions were associated with overall CSCC progression (p = 0.039 and p = 0.024, respectively) and chemoresistance (p = 0.004 and p = 0.014, respectively). Positive correlations were observed, between the expression of E6 and pGSK3β expression (p = 0.013); E6 and CSCC progression (p < 0.0001)/drug resistance (p = 0.0001). CisR–HeLa/–SiHa was more dependent on pGSK3β, and activation of GSK3 by SMIs (iAkt), treatment with nimbolide, or knockdown of E6/E7 reduced cisplatin resistance and promoted apoptosis. Hence, the activation of GSK3β with nimbolide and iAkt can be exploited for therapeutic interventions of cervical cancer.

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Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India

Cited by 18 publications

References 51 publications

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma

Prevotella as the hub of the cervicovaginal microbiota affects the occurrence of persistent human papillomavirus infection and cervical lesions in women of childbearing age via host NF‐κB/C‐myc

Glycogen synthase kinase‐3β inactivation promotes cervical cancer progression, invasion, and drug resistance

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