Polymorphisms in interleukin-6 and interleukin-10 may be associated with risk of preeclampsia

Fan, Dai Ming; Wang, Y; Xl, Liu; A, Zhang; Xu, Qi

doi:10.4238/gmr16018588

Cited by 25 publications

(32 citation statements)

References 33 publications

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“…A meta‐analysis including four studies has investigated the role of IL‐6‐174G/C and found no significant relationship with PE . This finding was confirmed by two subsequent studies in a Brazilian and Chinese population, respectively. However, in a recent study of 275 Indian women, a significant association between the IL‐6‐174G/C polymorphism and early‐onset PE was observed .…”

Section: Resultsmentioning

confidence: 80%

“…However, in a recent study of 275 Indian women, a significant association between the IL‐6‐174G/C polymorphism and early‐onset PE was observed . IL‐6 ‐572G/C and −597G/A did not present any correlation with the disease in Chinese women …”

Section: Resultsmentioning

confidence: 82%

“…The first study in the field indicated that the genotype −2849A/A was correlated with threefold lower risk of developing preeclampsia (OR = 0.29, 95% CI: [0.10‐0.83]), while no influence of −1082, −819, and −592 polymorphisms was observed. Subsequently, in a case‐control study of 142 PE patients and 260 healthy controls, the frequency of the SNP IL‐10‐592CC was significantly higher in PE patients and carriers of the genotypes CC, AC had a higher incidence of PE compared with AA individuals (OR = 2.45, 1.71, respectively) . The results of SNP‐related studies have been assessed systematically in various meta‐analyses.…”

Section: Resultsmentioning

confidence: 99%

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The role of interleukins in preeclampsia: A comprehensive review

Bellos

Karageorgiou

Kapnias

et al. 2018

American J Rep Immunol

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Preeclampsia is a multi‐system hypertensive disorder of pregnancy, with significant rates of maternal and neonatal morbidity. It represents a major cause of preterm birth, as definitive treatment demands fetal delivery. Although its pathophysiology is complicated, placental hypoxia and endothelial dysfunction constitute established pathogenetic steps of the disease. Inflammation is considered to be a crucial mediator of preeclampsia process, as an imbalance between TH1, TH2, and TH17 immune responses is observed. The present review accumulates current knowledge about the contribution of interleukins in preeclampsia, summarizing the pathways through which each interleukin exerts its function in the disease. Also, the role of genetic polymorphisms is explored and the predictive efficacy of maternal serum interleukin levels is evaluated. Finally, recommendations about the safe interpretation of the outcomes, as well as guidance for future research, are provided.

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Section: Resultsmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

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The role of interleukins in preeclampsia: A comprehensive review

Bellos

Karageorgiou

Kapnias

et al. 2018

American J Rep Immunol

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“…An increased susceptibility for developing preeclampsia during pregnancy may be in part due to genetic influences on the immune system. Several reports highlight the association of cytokine gene polymorphisms with preeclampsia, such as IFN-γ (A874T), 174 IL-6 (G-174C), 182 IL-10 (A-592C), 183 and TNF-α (G-308A); 184 however, these results are still inconclusive and may only be reflective of specific ethnic groups. A recent review of meta-analyses examining genetic risk factors for preeclampsia found strongest evidence for PAI-1 4G/5G polymorphism.…”

Section: Preeclampsiamentioning

confidence: 99%

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

Mattina

Lieshout

Steiner

2019

Therapeutic Advances in Cardiovascular Disease

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Women are at increased risk for developing depression and cardiovascular disease (CVD) across the lifespan and their comorbidity is associated with adverse outcomes that contribute significantly to rates of morbidity and mortality in women worldwide. Immunesystem activity has been implicated in the etiology of both depression and CVD, but it is unclear how inflammation contributes to sex differences in this comorbidity. This narrative review provides an updated synthesis of research examining the association of inflammation with depression and CVD, and their comorbidity in women. Recent research provides evidence of pro-inflammatory states and sex differences associated with alterations in the hypothalamic-pituitary-adrenal axis, the renin-angiotensin-aldosterone system and the serotonin/kynurenine pathway, that likely contribute to the development of depression and CVD. Changes to inflammatory cytokines in relation to reproductive periods of hormonal fluctuation (i.e. the menstrual cycle, perinatal period and menopause) are highlighted and provide a greater understanding of the unique vulnerability women experience in developing both depressed mood and adverse cardiovascular events. Inflammatory biomarkers hold substantial promise when combined with a patient's reproductive and mental health history to aid in the prediction, identification and treatment of the women most at risk for CVD and depression. However, more research is needed to improve our understanding of the mechanisms underlying inflammation in relation to their comorbidity, and how these findings can be translated to improve women's health.

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“…Moreover, Kemse et al (31) supposed a role for micronutrient deficiency for development of pregnancy-induced hypertension (PIH) and experimentally found PIH induction increased the mRNA levels of IL-6, while lowering the placental anti-inflammatory cytokine IL-10 and the combined supplementation of folic acid, vitamin B 12 and omega-3 fatty acids improved placental IL-10 levels and decreased TNF-α levels, while, Fan et al (32) found the AA genotype, compared to the CC and AC+CC genotypes of IL-10-592A/C correlate with elevated risk of developing PE.…”

mentioning

confidence: 99%