Polymorphisms in&lt;i&gt; ACE&lt;/i&gt; and &lt;i&gt;ACTN3&lt;/i&gt; Genes and Blood Pressure Response to Acute Exercise in Elite Male Athletes from Serbia

Durmic, Tijana; Zdravković, Marija; Djelić, Marina; Gavrilovic, Tamara; Saranovic, Slavica A. Djordjevic; Plavsic, Jadranka; Mirkovic, Sanja; Batinic, Djordje V.; Antic, Milena; Mihailovic, Zoran; Nikola, Atanasijevic; Mileusnic, Milan J.; Stojković, Oliver

doi:10.1620/tjem.243.311

Cited by 16 publications

(8 citation statements)

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“…Polymorphism in angiotensin converting enzyme gene is one of the most frequent examined factors related to sports predispositions. ACE gene is also associated with differences with blood pleasure [24] and fertility [1,25], cardiovascular diseases [1,26–28], neurological diseases like Parkinson’s disease [1,29] or Alzheimer disease [1,30,31]. Since years, many of scientists study the role of Insertion/ Deletion polymorphism and their correlation between genetic and physiological backgrounds in sportspeople.…”

Section: Discussionmentioning

confidence: 99%

“…Since years, many of scientists study the role of Insertion/ Deletion polymorphism and their correlation between genetic and physiological backgrounds in sportspeople. Most research was concentrated on polymorphism in angiotensin converting enzyme (ACE) among athletes [32–36], swimmers [1,37,38], football players [39], volleyball players [24,40] or ball games players [41]. There is no research relating to ACE polymorphism among horse riders.…”

Section: Discussionmentioning

confidence: 99%

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Genetic conditionality of strength by the ACE gene in women horse riders

Majchrowicz

Matłosz

2020

Preprint

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25The sport performance relies on hard work, intensity, duration of workout and 26 undoubtedly on genetic background. These components fold on multicausal character of 27 sport achievements. One of the best known genes associated with sport performance is 28 angiotensin converting enzyme gene (ACE). In this study, we showed ACE distribution 29 in women horse riders and the correlation between physiological and genetic 30 background, that should be taken into account when deciding to train sports discipline. 31 Data from 40 healthy female adults were collected. Participants trained horse-riding for 32 at least 3 years and participated in sport competition at least at national level and control 33 group consist of out of training persons. We analysed BMI, %FAT, cardiorespiratory 34 efficiency (VO2max), Complex Reaction Time, body balance, force and Lower Limbs 35 Explosive Force between both calculated groups. Physiological data was calculated by 36 non-parametric Mann-Whitney test with Dunnett`s post hoc test. The DNA 37 amplification from saliva was performed by PCR method to analyze the ACE genotype 38 distribution. In our study, for the first time we showed that the women training dressage 39 have higher force and complex reaction time than the control group. It was correlated 40 with possession of the D allele in genotype that is associated with muscle strength, 41 efficiency and muscle power. There is no research relating to ACE polymorphism 42 among horse riders. This paper showed angiotensin converting enzyme gene 43 distribution polymorphism in female Polish professional horse riders. This article 44 confirms correlation between genotype, sports results and physiological parameters.45 3 47 1. INTRODUCTION 48 Angiotensin converting enzyme (ACE) is well-known and one of the most 49 frequent under examined gene among sportsmen. An insertion/deletion (I/D) 50 polymorphism in the ACE gene occurrence is responsible for the control of blood 51 pressure in the body [1], as well as for predisposition to short-term or strength sports. 52 It's been long since known that sport success is the sum of genetic predisposition and 53 regular training. There is a lot of research of frequency of an insertion/deletion of 54 polymorphism among sportspeople training various olympic disciplines. Lack of 55 literature concerning I/D ACE polymorphism with horse-riders [1]. The aim of this 56 study was to show insertion/deletion of polymorphism in the ACE gene correlated with 57 horse-riders' physical condition and their professing sport discipline and enrich existing 58 literature about genetics of athletic performance. We also wanted to enrich the current 59 canon of knowledge about equestrianism.60Horse-riding is a highly demanding sport rank among olympic disciplines. It 61 split into 7 groups: dressage, show jumping, teaming, western riding, vaulting, long-62 distance rail and three-day event. Regardless of trained discipline, horse-riding demands 63 high physical condition, force and strength. Riding is most prestigious and...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genetic conditionality of strength by the ACE gene in women horse riders

Majchrowicz

Matłosz

2020

Preprint

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“…However, these aspects are not completely elucidated, especially regarding the varied types of exercise with different influences on perfusion-dependent aspects of skeletal muscle metabolism. Influences on muscle perfusion are, for instance, expected to result from a high load or lengthening of actively contracting skeletal muscle owing to the resulting compression or stretch of capillaries (reviewed in Durmic et al [19][20][21]). This directly yields to the aim of this study to investigate the ACE I/D genotype-specific effects of interval exercise training, comprising a blend of eccentric and concentric contractions on short maximal muscle performance and endurance-related performance of peripheral muscle, cardio-respiration and aerobic muscle metabolism in healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

ACE-I/D Allele Modulates Improvements of Cardiorespiratory Function and Muscle Performance with Interval-Type Exercise

Gasser

Niederseer

Frey³

et al. 2023

Genes

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Background: The prominent insertion/deletion polymorphism in the gene for the major modulator of tissue perfusion, angiotensin-converting enzyme (ACE-I/D) is associated with variability in adjustments in cardiac and skeletal muscle performance with standard forms of endurance and strength type training. Here, we tested whether the ACE-I/D genotype would be associated with variability in the effects of interval-type training on peak and aerobic performance of peripheral muscle and cardio-vasculature and post-exercise recovery. Methods: Nine healthy subjects (39.0 ± 14.7 years of age; 64.6 ± 16.1 kg, 173.6 ± 9.9) completed eight weeks of interval training on a soft robotic device based on repeated sets of a pedaling exercise at a matched intensity relative to their peak aerobic power output. Prior to and post-training, peak anaerobic and aerobic power output was assessed, mechanical work and metabolic stress (oxygen saturation and hemoglobin concentrations of Musculus vastus lateralis (VAS) and Musculus gastrocnemius (GAS), blood lactate and factors setting cardiac output such as heart rate, systolic and diastolic blood pressure were monitored during ramp-incremental exercise and interval exercise with the calculation of areas under the curve (AUC), which were put in relation to the produced muscle work. Genotyping was performed based on I- and D-allele-specific polymerase chain reactions on genomic DNA from mucosal swaps. The significance of interaction effects between training and ACE I-allele on absolute and work-related values was assessed with repeated measures ANOVA. Results: Subjects delivered 87% more muscle work/power, 106% more cardiac output, and muscles experienced ~72% more of a deficit in oxygen saturation and a ~35% higher passage of total hemoglobin during single interval exercise after the eight weeks of training. Interval training affected aspects of skeletal muscle metabolism and performance, whose variability was associated with the ACE I-allele. This concerned the economically favorable alterations in the work-related AUC for the deficit of SmO2 in the VAS and GAS muscles during the ramp exercise for the I-allele carriers and opposing deteriorations in non-carriers. Conversely, oxygen saturation in the VAS and GAS at rest and during interval exercise was selectively improved after training for the non-carriers of the I-allele when the AUC of tHb per work during interval exercise deteriorated in the carriers. Training also improved aerobic peak power output by 4% in the carriers but not the non-carriers (p = 0.772) of the ACE I-allele while reducing negative peak power (−27.0%) to a lesser extent in the ACE I-allele carriers than the non-carriers. Variability in cardiac parameters (i.e., the AUC of heart rate and glucose during ramp exercise, was similar to the time to recovery of maximal tHb in both muscles after cessation of ramp exercise, only associated with the ACE I-allele but not training per se. Diastolic blood pressure and cardiac output during recovery from exhaustive ramp exercise demonstrated a trend for training-associated differences in association with the ACE I-allele. Discussion: The exercise-type dependent manifestation of antidromic adjustments in leg muscle perfusion and associated local aerobic metabolism between carriers and non-carriers of the ACE I-allele with the interval-training highlight that non-carriers of the I-allele do not present an essential handicap to improve perfusion-related aerobic muscle metabolism but that the manifestation of responsiveness depends on the produced work. Conclusions: The deployed interval-type of exercise produced ACE I-allele-related differences in the alterations of negative anaerobic performance and perfusion-related aerobic muscle metabolism, which manifestation is exercise specific. The training-invariant ACE I-allele-associated differences in heart rate and blood glucose concentration emphasize that the repeated impact of the interval stimulus, despite a near doubling of the initial metabolic load, was insufficient to overturn ACE-related genetic influences on cardiovascular function.

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“…ACE converts angiotensin I into angiotensin II, which form part of the renin-angiotensinaldosterone system and are responsible for controlling bodily fluids and especially blood pressure (Guth & Roth 2013, Durmic et al 2017). The variants associated with an ACE polymorphism (rs1799752) have an influence in terms of reducing and increasing enzymatic activity, alleles I (insertion) and D (deletion) of a 287-base pair (bp) Alu element fragment at intron 16, whit the genotypes (II, ID and DD), respectively (Lima et al 2011, Costa et al 2021.…”

Section: Introductionmentioning

confidence: 99%

Association between ACE and ACTN3 genetic polymorphisms and the effects of different physical training models on physically active women aged 50 to 75

Rodrigues

Prado

Almeida

et al. 2022

An. Acad. Bras. Ciênc.

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The aim of this study was to analyze the association between ACE (DD + ID versus II) and ACTN3 (TT + TC versus CC) polymorphisms in the response of multicomponent physical training programs and combined in the health parameters of physically active women aged 50 to 75 years. Participants were randomly divided into two groups: multicomponent training and combined training. Intervention lasted 14 weeks, 180 minutes a week. Genomic DNA was extracted from blood samples and genotyping analyzes were performed by conventional and real-time PCR. Associations were observed between polymorphisms in anthropometric measurements, blood pressure, physical capacity and quality of life in both models physical training, with improvement in group II -(ACEmulticomponent training in terms of abdominal circumference and sit-to -Combined training in terms of waist circumference) and TT + TC group (ACTN3 -multicomponent training in tests of muscle strength and mental quality of life domain, and combined training in body mass index, waist circumference, diastolic blood pressure, upper limb strength and cardiorespiratory capacity). Fourteen weeks of multicomponent and combined physical training in physically active women aged 50 to 75 years resulted in greater health benefits for genotypes II (ACE) and TT + TC (ACTN3).

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Polymorphisms in<i> ACE</i> and <i>ACTN3</i> Genes and Blood Pressure Response to Acute Exercise in Elite Male Athletes from Serbia

Cited by 16 publications

References 31 publications

Genetic conditionality of strength by the ACE gene in women horse riders

Genetic conditionality of strength by the ACE gene in women horse riders

ACE-I/D Allele Modulates Improvements of Cardiorespiratory Function and Muscle Performance with Interval-Type Exercise

Association between ACE and ACTN3 genetic polymorphisms and the effects of different physical training models on physically active women aged 50 to 75

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