Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Abstract

Background: Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon. Methods: The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A were genotyped and serum zinc (Zn) level was measured. The cancer risk was calculated using multivariable logistic regression with respect to Zn. Results: None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for MMP-2, MMP-7 and MT2A non-significant differences in genotypes frequencies among cases and controls were observed. Conclusions: Analyses of polymorphisms, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A in relation to serum Zn level did not show significant association with breast, lung and colon cancer risk among polish patients. Further studies are needed to verify this observation.

Overexpressed Thrombospondin 2 Induced Osteogenic Differentiation of Valve Interstitial Cells via Inhibition of Akt/NF-κB Signaling Pathway to Promote Calcific Aortic Valve Disease Development

“…CTGF is reported to be a profibrotic growth factor which fulfills a vital function on pathogenesis of tissue fibrosis [ 43 ]. MMP-2 and MMP-13 are two members of MMPs which are a group of zinc containing enzymes implicated in the remodeling of ECM [ 44 ]. Both of them are verified to have a profound impact on bone formation and remodeling [ 45 , 46 ].…”

KLF4, a Key Regulator of a Transitive Triplet, Acts on the TGF-β Signaling Pathway and Contributes to High-Altitude Adaptation of Tibetan Pigs

“…The ATOH8 gene participates in the ALK-1/SMAD/ATOH8 axis, which attenuated the hypoxic response in endothelial cells in the pulmonary circulation and might help prevent the development of pulmonary arterial hypertension (Morikawa et al, 2019). The MMP23B gene was a member of the MMP gene family, and MMP matrix metalloproteinases played an important role in tissue remodeling and angiogenesis (Białkowska et al, 2020). Moreover, MMP23B is regulated by EPAS1 and ssc-miR-296-3p.…”

Association of Two MMP-8 Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women

“…The MMP-8 gene is located on chromosome 11q22.2. It is used as one of the biomarkers of preterm delivery, because high concentrations of MMP-8 in the cervical fluid are associated with spontaneous preterm delivery [6].…”

“…The level of MMP-8 in cervical fluid of pregnant women changes based on the pregnancy time. Studies have shown that high expression of MMP-8 in amniotic fluid is associated with an increased risk of spontaneous preterm delivery [6,7]. On the other hand, some Single Nucleotide Polymorphisms (SNPs) in MMP-8 genes have been associated with pathogenesis of different diseases, including pre-term labor [8][9][10][11].…”