Polymorphisms in NFKB1 and NFKBIA Genes Modulate the Risk of Developing Prostate Cancer among Han Chinese

Han, Xiao; Zhang, Jiajun; Yao, Nan; Wang, Gang; Martino, Juan; Li, Bo; Li, Chao; Wang, Zi-an

doi:10.12659/msm.893471

Cited by 16 publications

(7 citation statements)

References 29 publications

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“… 41 conducted their research in two different places (eastern and southern china), which were treated as four individual comparisons. Therefore, a total of 42 studies from 36 articles were identified, including 43,000 subjects (18,222 cases and 24,778 controls) 8 10 13 19 20 21 22 23 24 25 26 27 28 29 30 32 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 . Of the 42 included studies, five studies involving 7,186 subjects reported on colorectal cancer (CRC).…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, Han et al . 38 demonstrated that the impact of the - 94 ins/del ATTG polymorphism was not present in nonsmokers and younger subjects in prostate cancer. Consequently, only increasing the number of populations, without taking into clinical and demographic information into account, will not guarantee the validity of the results.…”

Section: Discussionmentioning

confidence: 97%

“…Henceforth, some new studies further assessed the relationship between the polymorphism and cancer risk among multiple ethnic populations. However, the association remains inconclusive due to the inconsistent results from the published publications 23 24 25 26 27 30 36 37 38 39 40 41 42 . Therefore, the data need to be updated and more reliable evaluations of the polymorphism with cancer risk are warranted.…”

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confidence: 99%

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Genetic association between NFKB1 −94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies

Xie

Wang

et al. 2016

Sci Rep

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Accumulating evidences have indicated that the functional -94 ins/del ATTG polymorphism in the promoter region of human nuclear factor-kappa B1 (NFKB1) gene may be associated with cancer risk. However, some studies yielded conflicting results. To clarify precise association, we performed a comprehensive meta-analysis of 42 case-control studies involving 43,000 subjects (18,222 cases and 24,778 controls). The overall results suggested that the -94 ins/del ATTG polymorphism had a decreased risk for cancer, reaching significant levels in five genetic models (dominant model: OR = 0.86, 95% CI = 0.79–0.95, P = 0.002; recessive model: OR = 0.84, 95% CI = 0.74–0.94, P = 0.003; homozygous model: OR = 0.77, 95% CI = 0.66–0.90, P = 0.001; heterozygous model: OR = 0.90, 95% CI = 0.83–0.98, P = 0.011; allelic model: OR = 0.89, 95% CI = 0.83–0.96, P = 0.002). Furthermore, the -94 ins/del ATTG polymorphism could confer a decreased or increased risk for cancer development among Asians and Caucasians, respectively. Additionally, the stratification analysis revealed a significant association between the variant and decreased risk of oral, ovarian, and nasopharyngeal cancer in Asians. After we adjusted p values using the Benjamini-Hochberg false discovery rate method to account for multiple comparisons, these associations remained.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

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Genetic association between NFKB1 −94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies

Xie

Wang

et al. 2016

Sci Rep

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“…MyD88 is combined with downstream signal molecules, such as IL-1R associated kinase 4 (IRAK4) and release tumor necrosis factor associated factor 6 (TRAF6); the activated TRAF6 then releases NF-κB through a series of enzymatic reactions [ 47 ]. NF-κB can be combined with the promoters of inflammatory genes to regulate downstream gene expressions [ 48 , 49 ]. Studies have shown that NF-κB can inhibit cell apoptosis and prolong cell survival [ 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Toll-Like Receptor 4 (TLR4)/Cyclooxygenase-2 (COX-2) Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion by NF-κB Activation

Wang

2018

Med Sci Monit

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BackgroundToll-like receptor 4 (TLR4)-mediated signaling has been implicated in invasion, metastasis, and survival of various cancers. Activation of TLR4 can promote cyclooxygenase-2 (COX-2) and nuclear factor-κB (NF-κB). However, little is known about the effects of TLR4/COX-2 in prostate cancer (PCa).Material/MethodsIn our study, TLR4 and COX-2 expressions were detected by quantitative real-time reverse transcription PCR (qRT-PCR) in PCa tissues (n=34). Cell proliferation was measured by Cell Counting Kit-8 (CCK-8) and carboxyfluorescein succinimidyl ester (CFSE) assays. The migration and invasion abilities were detected by wound healing and Transwell assays. qRT-PCR and western blot assays were performed to detect TLR4, COX-2, matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of matrix metalloproteinases (TIMP)-1, epithelial-cadherin (E-cadherin), vimentin, NF-κB (p65), and p-p65 expressions.ResultsThe results revealed that TLR4 and COX-2 were upregulated in PCa tissues; Silencing of TLR4 or COX-2 inhibited PCa cell proliferation, migration, and invasion, and TLR4 siRNAs combined with COX-2 siRNAs synergistically suppressed PCa cell proliferation, migration, and invasion. Silencing of TLR4 or COX-2 also downregulated MMP-2, MMP-9, and E-cadherin expressions, and upregulated TIMP-1 and vimentin expressions. In addition, silencing of TLR4 or COX-2 inhibited p65 phosphorylation and had a synergistic effect.ConclusionsWe demonstrated that TLR4/COX-2 inhibits PCa cell proliferation, migration, and invasion by regulating NF-κB.

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“…For example, it was stated that a few deletions of the NFKBIA gene is associated with glioblastomas (Patanè et al, 2013). Han et al (2015) reported that polymorphisms in the NFKBIA genes may modulate the risk of developing prostate cancer in the Chinese population. Moreover, the importance of negative innate immune regulators such as NFKBIA has been verified in pediatric lung diseases, and studies have begun to unravel certain common aspects between genetic predisposition to childhood asthma and lung diseases (Ali et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

A network approach predicts NFKBIA and BIRC3 as pathogenic genes in childhood asthma

Gao

2016

Genet. Mol. Res.

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ABSTRACT. This study aimed to predict pathogenic genes of childhood asthma based on molecular interaction networks and gene expression data. Known pathogenic genes identified from the human protein-protein interaction network were denoted as seed genes, and were included in network A. We extracted sub-network B (pathogenic network), which consisted of genes that interacted with at least two seed genes. We assigned a weight to select the pathogenic genes from this network according to its interactions and co-expressions with the seed genes. We also conducted ClusterONE analysis for the pathogenic network, and determined the statistical significance of the predicted clusters through a significance score (SS). Lastly, we investigated the biological pathways of the seed and candidate genes based on information obtained from the KEGG database. In network A, we identified 172 interactions and 125 genes that interacted with seed genes. In the pathogenic network, we found 51 genes and 102 interactions. The top 10 candidate genes with high weight scores were recorded. The SS of the predicted clusters demonstrated that 3 gene clusters were statistically relevant for childhood asthma. Pathway analysis showed that the seed genes and the top 10 candidate genes were significantly enriched in the same three biological processes. NFKBIA and BIRC3, which were involved in all three biological processes, may therefore be pathogenic genes. Using the network approach, we predicted that the pathogenic genes NFKBIA and BIRC3 are associated with childhood asthma. This information can provide guidelines for future experimental verification of childhood asthma.

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Polymorphisms in NFKB1 and NFKBIA Genes Modulate the Risk of Developing Prostate Cancer among Han Chinese

Cited by 16 publications

References 29 publications

Genetic association between NFKB1 −94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies

Genetic association between NFKB1 −94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies

Toll-Like Receptor 4 (TLR4)/Cyclooxygenase-2 (COX-2) Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion by NF-κB Activation

A network approach predicts NFKBIA and BIRC3 as pathogenic genes in childhood asthma

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