Polymorphisms in pattern‐recognition genes in the innate immunity system and risk of non‐Hodgkin lymphoma

Abstract

The pattern-recognition pathway plays an important role in infection recognition and immune responses, and previous studies have suggested an association between genetic variation in innate immunity genes and non-Hodgkin lymphoma (NHL). We evaluated NHL risk associated with genetic variation in pattern-recognition genes using data from a case-control study of NHL conducted in Connecticut women. Single nucleotide polymorphisms (SNPs) in 27 pattern-recognition genes were genotyped in 432 Caucasian incident NHL cases and 494 frequency-matched controls. Unconditional logistic regression was used to compute odds ratios (ORs) for NHL and common NHL subtypes in relation to individual SNPs and haplotypes. A gene-based analysis that adjusted for the number of tagSNPs genotyped in each gene showed a significant association with overall NHL for the MBP gene (P = 0.028), with the diffuse large B-cell lymphoma (DLBCL) subtype for the MASP2 gene (P = 0.011), and with the follicular lymphoma (FL) subtype for DEFB126 (P = 0.041). A SNP-based analysis showed that MBP rs8094402 was associated with decreased risks of overall NHL (allele risk OR = 0.72, P-trend = 0.0018), DLBCL (allele risk OR = 0.72, P-trend = 0.036), and FL (allele risk OR = 0.67, P-trend = 0.021), while MASP2 rs12711521 was associated with a decreased risk of DLBCL (allele risk OR = 0.57, P-trend = 0.0042). We also observed an increased risk of FL for DEFB126 rs6054706 (allele risk OR = 1.39, P-trend = 0.033). Our results suggest that genetic variation in pattern-recognition genes is associated with the risk of NHL or specific NHL subtypes, but these preliminary findings require replication in larger studies.

Effects of MASP2 haplotypes and MASP‐2 levels in hepatitis C‐infected patients

“…Possibly due to viral mechanisms of complement attenuation, higher levels of lectin pathway recognition proteins and of complement activation seem to be necessary in controlling HCV infection. In agreement with this, higher ficolin‐2 levels and activity of C4 correlated with better response to treatment (Dumestre‐Perard et al., ; Hu et al., ) and MBL/MASP‐1 activity was related to severe fibrosis in hepatitis C patients (Alves Pedroso et al., ). However, the contribution of complement in direct lysis of HCV has not yet been demonstrated.…”

Single-Nucleotide Polymorphisms in Genes Encoding for CC Chemokines were Not Associated with the Risk of Non-Hodgkin Lymphoma

“…The distribution of age, education level, and family history of cancer in first-degree relatives was similar for cases and controls (8, 9). Of the 103 SNPs examined, two SNPs were not in HWE test and were excluded from the analysis (Supplementary Table 1).…”

“…Detailed descriptions of this study population and methods have been previously described (8, 9). Briefly, a total of 601 incident cases and 717 population-based controls were enrolled and completed in-person interviews.…”

The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT)

“…As with MBL, higher serum level of its associated serine protease-2 before chemotherapy seemed to be associated with hospital infections, at least in MM patients and Gram-positive bacterial agents. Earlier, MASP2 variant allele (SNP at position +1111) was suggested to be protective against DLBCL ( 62 ). Among 31 DLBCL patients studied here, 7 (22.6%) were heterozygotes (no difference in comparison to C group).…”