Polymorphisms in PPARD, PPARG and APM1 associated with four types of Traditional Chinese Medicine constitutions

Wu, Yuankui; Cun, Yina; Dong, Jing; Shao, Junfeng; Luo, Sushan; Nie, Shengjie; Yu, Hua; Zheng, Bingrong; Wang, Qi; Xiao, Chunjie

doi:10.1016/s1673-8527(09)60055-2

Cited by 41 publications

(30 citation statements)

References 26 publications

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“…Recently, some clinical differences among patterns were reported, and genetic factors have been correlated to PI in certain diseases [10–14]. …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, patients with Yin Deficiency pattern are nonobese and gaunt [1, 5, 8]. Wu et al reported that Pro12Ala SNP of PPARG polymorphism were associated with Yin Deficiency pattern in a Chinese Han population [14]. However, no genetic factors associated with the Yin Deficiency pattern have yet been established in a Korean population.…”

Section: Discussionmentioning

confidence: 99%

“…However, some reports have shown that inherent factors, such as genetic variations, are correlated with PI [10–14]. For example, a study in Chinese patients with coronary heart disease reported that the frequencies of the ε 4 allele and ε 3/4 genotype of the apolipoprotein E gene were significantly higher in patients with the phlegm pattern than in patients with the blood stasis pattern [10].…”

Section: Introductionmentioning

confidence: 99%

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WNT10B Polymorphism in Korean Stroke Patients with Yin Deficiency Pattern

Park

Lim

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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WNT10B has been indicated as a potential regulator of adipogenesis in vivo and in vitro models of obesity. In this study, we analyzed the distribution of WNT10B polymorphism in elderly Korean subjects with cerebral infarction (CI) and Yin Deficiency pattern and Non-Yin Deficiency pattern. A total of 630 CI patients, including 75 with Yin Deficiency pattern and 555 with Non-Yin Deficiency pattern, participated in this study. SNP (G-607C) genotyping was conducted by primer extension using TaqMan probe; five percent of subjects were regenotyped by direct sequencing to confirm the accuracy of the genotyping. The results were analyzed using a multiple logistic regression model to evaluate the genetic association between the G-607C variant and Yin Deficiency pattern. The frequency of the CC genotype of G-607C in the Yin Deficiency pattern group (29.33%) was significantly higher than that in the Non-Yin Deficiency pattern group (23.96%) (P = 0.0339 , OR = 2.005 (1.054–3.814)) in a recessive model. This is the first study to demonstrate an association between a WNT10B polymorphism and the Yin Deficiency pattern of traditional Korean medicine (TKM) in a CI patient population. These results suggest that G-607C might be used as a diagnostic genetic marker for Yin Deficiency pattern in stroke patients and in the development of personalized medical care.

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“…Recently, some clinical differences among patterns were reported, and genetic factors have been correlated to PI in certain diseases [10–14]. …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

WNT10B Polymorphism in Korean Stroke Patients with Yin Deficiency Pattern

Park

Lim

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…A study of metabonomics showed that Yang deficiency constitution exhibited disorders in energy, lipid, glucose and amino acid metabolism, as well as impaired organ function [7]. Single nucleotide polymorphisms (SNPs) in the PPARD, PPARG, and APM1 genes were shown to be associated with constitutions of both Yang deficiency and Yin deficiency [8]. A study using peripheral blood mononuclear cells (PBMCs) showed that expression profiling-based clustering of constitutional subjects largely overlaps with TCM classification and is consistent with the clinical observation that subjects with Yang deficiency tended towards obesity.…”

Section: Introductionmentioning

confidence: 99%

miRNA Expression Profile of Saliva in Subjects of Yang Deficiency Constitution and Yin Deficiency Constitution

Chen

Wu²,

Yao

et al. 2018

Cell Physiol Biochem

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Background/Aims: Based on the theory of constitution in Traditional Chinese Medicine (TCM), the Chinese Han population has been classified into nine constitutions. Of these, Yang deficiency constitution mainly exhibit cold intolerance while Yin deficiency constitution mainly exhibit heat intolerance. Some studies have been carried out to explore the modern genetic and biological basis of such constitution classification, but more remains to be done. MicroRNA (miRNA) serves as post-transcriptional regulators of gene expression and may play a role in the classification process. Here, we examined miRNA expression profile of saliva to further improve the comprehensiveness of constitution classification. Methods: Saliva was collected from Chinese Han individuals with Yang deficiency, Yin deficiency and Balanced constitutions (n=5 each), and miRNA expression profile was determined using the Human miRNA OneArray®v7. Based on 1.5 Fold change, means log₂|Ratio|≥0.585 and P-value< 0.05, differentially expressed miRNA was screened. Target genes were predicted using DIANA-TarBasev7.0 and analysis of KEGG pathway was carried out using DIANA-mirPathv.3. Results: We found that 81 and 98 differentially expressed miRNAs were screened in Yang deficiency and Yin deficiency constitution, respectively. Among them, 16 miRNAs were identical and the others were unique. In addition, the target genes that are regulated by the unique miRNAs were significantly enriched in 27 and 20 signaling pathways in Yang deficiency and Yin deficiency constitution, respectively. Thyroid hormone signaling pathway is present in both constitutions. These unique miRNAs that regulated target genes of thyroid hormone signaling pathway may be associated with cold intolerance or heat intolerance. Conclusion: The results of our study show that Yang deficiency and Yin deficiency constitutions exhibit systematic differences in miRNA expression profile. Moreover, the distinct characteristics of TCM constitution may be explained, in part, by differentially expressed miRNAs.

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“…So far the most researches of Yin-Yang syndrome are concentrated on Yin-deficiency syndrome and Yang-deficiency syndrome. Genomic information showed that Yang-deficiency patients had significant difference in Haplotype 25 (Hap25) of APM1 rs7627128, rs1063539, PSMB7, and CXCR4 compared to control group; however, Haplotype13 of PPARG in Yin-deficiency patients [11, 12]. At the proteomic level, it was found that CRP, CRH, IL10, ACE, PTH, MPO, CRH, PTH, PRL, BRCA1, BRCA2 [13], transthyretin, plasma retinol-binding protein precursor and chain A-prealbumin [14], liver protein, and protein of the liver mitochondria [15] levels correlated with Yang-deficiency syndrome.…”

Section: Research Status Of System Biology Application In Zctmentioning

confidence: 99%

ZHENG-Omics Application in ZHENG Classification and Treatment: Chinese Personalized Medicine

Dai

Fang

Sun

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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With the hope to provide an effective approach for personalized diagnosis and treatment clinically, traditional chinese medicine (TCM) is being paid increasing attention as a complementary and alternative medicine. It performs treatment based on ZHENG (TCM syndrome) classification, which could be identified clinical special phenotypes by symptoms and signs of patients even if they have a different disease. However, it caused controversy because ZHENG classification only depends on observation, knowledge, and clinical experience of TCM practitioners, which lacks objectivity and repeatability. Although researchers and scientists of TCM have done some work with a lot of beneficial methods, the results could not reach satisfactory with the shortcomings of generalizing the entire state of the body or ignoring the patients' feelings. By total summary, mining, and integration of existing researches, the present paper attempts to introduce a novel macro-microconcept of ZHENG-omics, with the prospect of bright future in providing an objective and repeatable approach for Chinese personalized medicine in an effective way. In this paper, we give the brief introduction and preliminary validation, and discuss strategies and system-oriented technologies for achieving this goal.

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Polymorphisms in PPARD, PPARG and APM1 associated with four types of Traditional Chinese Medicine constitutions

Cited by 41 publications

References 26 publications

WNT10B Polymorphism in Korean Stroke Patients with Yin Deficiency Pattern

WNT10B Polymorphism in Korean Stroke Patients with Yin Deficiency Pattern

miRNA Expression Profile of Saliva in Subjects of Yang Deficiency Constitution and Yin Deficiency Constitution

ZHENG-Omics Application in ZHENG Classification and Treatment: Chinese Personalized Medicine

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