Polymorphisms in renin-angiotensin-aldosterone system and vascular endothelial growth factor may cross talk in preeclampsia: a pilot study of maternal and fetal dyads in Indian population

Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection

“…In a study conducted in Chile, no association between PE and variants of the REN gene in offspring was reported [ 85 ]. In contrast, a strong correlation between REN ( rs 11240688) and AGT ( rs 11122576 G>A) foetal polymorphism and PE development was noted in a North Indian population study [ 86 ]. This observation indicates a strong association between foetal genotypes of REN and AGT that give rise to the stimulation of maternal RAAS and the disruption of angiogenesis, thereby triggering maternal PE.…”

“…Contrary to this finding, the GOPEC study revealed no association between PE and haplotypes of maternal AGT when investigating the relationship between 536 foetal triads (mother-father-child) and 398 maternal triads (grandmother-grandfather-mother) of British descent [ 107 ]. The variations of AGT ( rs7079 ) revealed staggering differences when evaluating PE prevalence, particularly the severe form and is, therefore comparable to the mild form of PE [ 86 ]. South Africans of African ancestry have salt-sensitive hypertension [ 111 ] and thus could be less accommodating to RAAS inhibitors [ 20 ••].…”

“…A greater distribution of AGT (MT) genotype compared to preeclamptic HIV-infected women African ancestry in South Africa [ 95 ••] AGT ( rs 7079) Polymorphisms in renin-angiotensin-aldosterone system and vascular endothelial growth factor may crosstalk in preeclampsia: a pilot study of maternal and foetal dyads in Indian population. The AGT (rs7079) polymorphism revealed a significant difference when assessing the prevalence of severe PE North India (Indo European origin) [ 86 ] ACE ( rs 4305) Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Directly proportional relationship between the ACE rs 4305 polymorphism and hypertension European ancestry [ 128 ] ACE ( rs 4343) The gene variants of maternal/fetal renin-angiotensin system in preeclampsia: a hybrid case-parent/mother-control study.…”