Polymorphisms in sex steroid receptors: From gene sequence to behavior

Maney, Donna L.

doi:10.1016/j.yfrne.2017.07.003

Cited by 30 publications

(17 citation statements)

References 271 publications

(278 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 2 kb region upstream of the transcription start site, for example, contains dozens of polymorphisms [30]. Cis-regulatory variation can impact transcription via several mechanisms (see [31]), such as when polymorphisms occur in transcription factor bindings sites, enhancers or DNA sequences that could be methylated. Given the robust morph differences in VIP expression observed in this study, we hypothesize that the ZAL2 and ZAL2 m alleles are differentially regulated and probably show allelic imbalance in both the anterior hypothalamus and infundibular region.…”

Section: Discussionmentioning

confidence: 99%

Vasoactive intestinal peptide as a mediator of the effects of a supergene on social behaviour

et al. 2020

Self Cite

View full text Add to dashboard Cite

Supergenes, or linked groups of alleles that are inherited together, present excellent opportunities to understand gene–behaviour relationships. In white-throated sparrows ( Zonotrichia albicollis ), a supergene on the second chromosome associates with a more aggressive and less parental phenotype. This supergene includes the gene for vasoactive intestinal peptide (VIP), a neuropeptide known to play a causal role in both aggression and parental behaviour. Here, using a free-living population, we compared the levels of VIP mRNA between birds with and without the supergene. We focused on the anterior hypothalamus and infundibular region, two brain regions containing VIP neurons known to play a causal role in aggression and parental behaviour, respectively. First, we show that the supergene enhances VIP expression in the anterior hypothalamus and that expression positively predicts vocal aggression independently of genotype in both sexes. Next, we show that the supergene reduces VIP expression in the infundibular region, which suggests reduced secretion of prolactin, a pro-parental hormone. Thus, the patterns of VIP expression in these two regions are consistent with the enhanced aggression and reduced parental behaviour of birds with the supergene allele. Our results illustrate mechanisms by which elements of genomic architecture, such as supergenes, can contribute to the evolution of alternative behavioural phenotypes.

show abstract

Section: Discussionmentioning

confidence: 99%

Vasoactive intestinal peptide as a mediator of the effects of a supergene on social behaviour

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nucleotide polymorphisms of AR and ESR1 of mammals have been studied in great detail, in particular in relation with carcinoma differentiation (Dos Santos et al 2017 ; Eisenegger et al 2017 ) and are thought to correlate with human behavioral and neurological problems (Maney 2017 ). In birds, such analysis in association with neural and behavioral phenotypes is missing.…”

Section: Receptor Structure: Species Differences and Tissue-specific mentioning

confidence: 99%

Androgen and estrogen sensitivity of bird song: a comparative view on gene regulatory levels

Frankl-Vilches

Gahr

2017

J Comp Physiol A

View full text Add to dashboard Cite

Singing of songbirds is sensitive to testosterone and its androgenic and estrogenic metabolites in a species-specific way. The hormonal effects on song pattern are likely mediated by androgen receptors (AR) and estrogen receptor alpha (ERα), ligand activated transcription factors that are expressed in neurons of various areas of the songbirds' vocal control circuit. The distribution of AR in this circuit is rather similar between species while that of ERα is species variant and concerns a key vocal control area, the HVC (proper name). We discuss the regulation of the expression of the cognate AR and ERα and putative splice variants. In particular, we suggest that transcription factor binding sites in the promoter of these receptors differ between bird species. Further, we suggest that AR-and ERα-dependent gene regulation in vocal areas differs between species due to species-specific DNA binding sites of putative target genes that are required for the transcriptional activity of the receptors. We suggest that species differences in the distribution of AR and ERα in vocal areas and in the genomic sensitivity to these receptors contribute to species-specific hormonal regulation of the song.

show abstract

“…Ingenuity pathway analysis (IPA) also identified multiple signaling pathways previously implicated in depression ( Fig. 4A), including estrogen receptor signaling (20), glucocorticoid receptor signaling (21), activin signaling (22), and the NRF2-mediated antioxidant response (23) ( Fig. 4B and SI Appendix, Figs.…”

Section: Resultsmentioning

confidence: 99%

Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior

Nakayama

Okimura

Shen

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Seasonal changes in the environment lead to depression-like behaviors in humans and animals. The underlying mechanisms, however, are unknown. We observed decreased sociability and increased anxiety-like behavior in medaka fish exposed to winter-like conditions. Whole brain metabolomic analysis revealed seasonal changes in 68 metabolites, including neurotransmitters and antioxidants associated with depression. Transcriptome analysis identified 3,306 differentially expressed transcripts, including inflammatory markers, melanopsins, and circadian clock genes. Further analyses revealed seasonal changes in multiple signaling pathways implicated in depression, including the nuclear factor erythroid-derived 2-like 2 (NRF2) antioxidant pathway. A broad-spectrum chemical screen revealed that celastrol (a traditional Chinese medicine) uniquely reversed winter behavior. NRF2 is a celastrol target expressed in the habenula (HB), known to play a critical role in the pathophysiology of depression. Another NRF2 chemical activator phenocopied these effects, and an NRF2 mutant showed decreased sociability. Our study provides important insights into winter depression and offers potential therapeutic targets involving NRF2.

show abstract

Polymorphisms in sex steroid receptors: From gene sequence to behavior

Cited by 30 publications

References 271 publications

Vasoactive intestinal peptide as a mediator of the effects of a supergene on social behaviour

Vasoactive intestinal peptide as a mediator of the effects of a supergene on social behaviour

Androgen and estrogen sensitivity of bird song: a comparative view on gene regulatory levels

Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior

Contact Info

Product

Resources

About