Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes

Korolija, Marina; Jemin, Nikolina; Pavković, Iva; Pavković, Pajica; Medvidović, Edita Pape; Hadžija, Mirko

doi:10.1016/j.gene.2012.10.029

Cited by 16 publications

(6 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The genotypic and allelic frequencies did not differ between the study groups (Table 2). Similar results were found in other studies with Caucasian (Novota et al, 2005, Szeszko et al, 2006, Hadzija et al, 2013, Turkish (Altinova et al, 2010), Iranian (Mojtahedi et al, 2006), and Brazilian populations (Tavares et al, 2013). Some studies did not report any association between different 607 IL18 (rs1946518) genotypes and the onset age in adult T1DM patients (Altinova et al, 2010), or T1DM in adults or Latent Autoimmune Diabetes of the Adult (LADA) (Novota et al, 2005), which was in accordance with our results; however, significant associations were found with T1DM in Asian populations (Dong et al, 2007, Lee et al, 2015.…”

Section: Discussionsupporting

confidence: 92%

Research Article The IL18 rs1946518 and PTPN22 rs2476601 polymorphisms are not associated with adult- and childhood-onset type 1 diabetes mellitus

Campos¹,

Graciolo²,

Welter³

et al. 2020

Genet. Mol. Res.

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Research Article The IL18 rs1946518 and PTPN22 rs2476601 polymorphisms are not associated with adult- and childhood-onset type 1 diabetes mellitus

Campos¹,

Graciolo²,

Welter³

et al. 2020

Genet. Mol. Res.

View full text Add to dashboard Cite

“…The prevalence of T1DM accounts for 5-10% of all diabetes cases (Gale, 2002;Awoniyi et al, 2013;Lipman et al, 2013). Although the exact pathogenesis of T1DM is unknown, T1DM is thought to involve multifactor disorders resulting from genetic polymorphisms as well as various environmental factors (Rich et al, 2006;Ei Wafai et al, 2011;Pehlić et al, 2012;Hadžija et al, 2013). Previous studies have indicated that genetic polymorphisms in genes such as TRAIL (Bernardi et al, 2012), HLA (Black and Dabelea, 2013), and CCR5 (Yang et al, 2004) were associated with T1DM risk.…”

Section: Introductionmentioning

confidence: 99%

Association of PTPN22 gene polymorphism with type 1 diabetes mellitus in Chinese children and adolescents

et al. 2015

View full text Add to dashboard Cite

ABSTRACT. Previous studies have indicated that the protein tyrosine phosphatase nonreceptor type 22 gene (PTPN22) is associated with type 1 diabetes (T1DM) in the Caucasian population. In the present study, we investigated the relationship between PTPN22 genetic polymorphisms and T1DM in Chinese children. A total of 202 children and adolescents with T1DM and 240 healthy control subjects of Chinese Han origin were included in our analysis. Polymerase chain reaction-restriction fragment length polymorphism was used to determine the presence of the C1858T polymorphism in the PTPN22 gene. We found that the TT +TC genotype and the T allele of C1858T were more frequent in T1DM patients (19.40 and 10.0%, respectively) than in healthy subjects (7.51 and 4.0%, respectively), and the difference was significant (both P < 0.001). After adjusting for confounding variables such as gender, age, and family history of T1DM, the difference remained significant (P = 0.007, odds ratio = 2.88, 95% confidence interval 1.76-4.32). Our results indicate that genetic polymorphisms in the PTPN22 gene may increase the risk of T1DM in Chinese children and adolescents.

show abstract

“…In the studied diabetic population, significantly higher levels of HbA1c were present in T1DM carriers of the genotype with the A allele (AA + AG genotypes) versus the GG homozygotes (76.6 mmol/mol ± 16.5 mmol/mol versus 69.8 mmol/mol ± 13.9 mmol/mol). To our knowledge, no previous study has focused on this issue; however, polymorphisms in other genes, for example, IL-6 [ 46 ] and IL-18 separately [ 47 ] or in combination with the IL-12B gene [ 48 ], have been associated with higher concentration of HbA1c in T1DM populations.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-17AGene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria

Linhartová

Kaštovský

Lučanová

et al. 2016

Mediators of Inflammation

View full text Add to dashboard Cite

Interleukin-17 contributes to the pathogenesis of type 1 diabetes mellitus (T1DM) and chronic periodontitis (CP). We analyzed IL-17A −197A/G and IL-17F +7488C/T polymorphisms in T1DM and CP and determined their associations with IL-17 production and occurrence of periopathogens. Totally 154 controls, 125 T1DM, and 244 CP patients were genotyped using 5′ nuclease TaqMan® assays. Bacterial colonization was investigated by a DNA-microarray kit. Production of IL-17 after in vitro stimulation of mononuclear cells by mitogens and bacteria was examined by the Luminex system. Although no differences in the allele/genotype frequencies between patients with CP and T1DM + CP were found, the IL-17A −197 A allele increased the risk of T1DM (P < 0.05). Levels of HbA1c were significantly elevated in carriers of the A allele in T1DM patients (P < 0.05). Production of IL-17 by mononuclear cells of CP patients (unstimulated/stimulated by Porphyromonas gingivalis) was associated with IL-17A A allele (P < 0.05). IL-17A polymorphism increased the number of Tannerella forsythia and Treponema denticola in patients with CP and T1DM + CP, respectively (P < 0.05). IL-17A gene variability may influence control of T1DM and the “red complex” bacteria occurrence in patients with CP and T1DM + CP. Our findings demonstrated the functional relevance of the IL-17A polymorphism with higher IL-17 secretion in individuals with A allele.

show abstract

Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes

Cited by 16 publications

References 37 publications

Research Article The IL18 rs1946518 and PTPN22 rs2476601 polymorphisms are not associated with adult- and childhood-onset type 1 diabetes mellitus

Research Article The IL18 rs1946518 and PTPN22 rs2476601 polymorphisms are not associated with adult- and childhood-onset type 1 diabetes mellitus

Association of PTPN22 gene polymorphism with type 1 diabetes mellitus in Chinese children and adolescents

Interleukin-17AGene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria

Contact Info

Product

Resources

About