Polymorphisms in the MMP1 and MMP3 promoter and non-small cell lung carcinoma in North China

Fang, Shumei; Jin, Xia; Wang, Rui; Li, Yan; Guo, Wei; Wang, Na; Wang, Yimin; Wen, Di; Wei, Luqing; Zhang, Jianhui

doi:10.1093/carcin/bgh327

Cited by 102 publications

(114 citation statements)

References 27 publications

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“…The MMP 2G/6a haplotype was associated with lower risk of lymphatic metastasis of lung cancer when compared to the 1G/5a haplotype in a chinese population (69). However, in a uS population, another haplotype (1G/6a/82a/1082G), including MMP-1 (1G/2G), MMP-3 (5a/6a) and MMP-12 (-82aG, 1082a/G), showed an association with a higher risk of lung cancer among never smokers (14).…”

Section: Haplotype Influencementioning

confidence: 88%

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MMP-3 polymorphism: Genetic marker in pathological processes (Review)

2010

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Abstract. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are collectively capable of cleaving virtually all extracellular matrix (ecM) substrates and play an important role in diverse physiological and pathological processes. The activity of MMPs is controlled at multiple levels, and the transcriptional regulation of MMPs appears to represent a necessary step in its regulation. MMP-3 is a key member of the MMP family with broad substrate specificity, and is crucial to the connective tissue remodeling process. it is also involved in the turnover of the numerous ecM components. a common functional promoter polymorphism of MMP-3, 5a/6a, affects its activity and has been associated with various diseases. This polymorphism may be used as a genetic marker for certain pathologies to identify individual susceptibility. This review discusses various topics related to MMP-3 in pathological processes, with a focus on the 5a/6a polymorphism. Contents1. introduction 2. Matrix metalloproteinase-3 3. 5a/6a polymorphism of MMP-3 4. Pathological processes and the MMP-3 5a/6a polymorphism 5. Haplotype influence IntroductionThe evidence that individual characteristics play an important role in physiological and pathological processes has resulted in the targeted study of genetic polymorphisms in the clinical setting. in this context, mediators that degrade the extracellular matrix (ecM), such as matrix metalloproteinases (MMPs), are highlighted in studies involving inflammatory and degenerative diseases, and principally the prognosis and metastasis of cancer.degradation of the ecM is essential in many physiological processes, such as during development, growth and repair of tissue, and the microenvironment plays a central role in controlling both normal and transformed cell functions, as well as normal tissue integrity (1).MMPs are a pivotal family of zinc enzymes responsible for the degradation of ecM components, including basement membrane collagen, interstitial collagen, fibronectin and various proteoglycans, during normal remodeling and repair processes in development and inflammation. MMPs are also peptidase enzymes responsible for clotting factors, lipoproteins, latent growth factors and chemotactic and cell adhesion molecules (2,3). in this way, MMPs play a key role in the physiologic remodeling of tissues, including embryogenesis and tissue morphogenesis, angiogenesis, cell migration, proliferation, apoptosis, alteration of cell motility, effects on the immune system, wound repair and the inflammatory response (4).MMPs are a family of more than 25 enzymes. The expression of most MMPs is normally low in tissues and is induced when remodeling of the ecM is required. MMP gene expression is regulated primarily at the transcriptional level, but there is also evidence of the modulation of mrna stability in response to growth factors and cytokines (5). The promoter region of inducible MMP genes (i.e., MMP-3) shows remarkable conservation of regulatory elements, and their expression is induced ...

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Section: Haplotype Influencementioning

confidence: 88%

“…Fang et al (69) showed that the 1G/6a haplotype may play a protective role in the development of adult astrocytoma, whereas the MMP-3 5a/6a polymorphism is not necessarily an independent factor influencing susceptibility to astrocytoma in individuals from northern china.…”

Section: Haplotype Influencementioning

confidence: 99%

MMP-3 polymorphism: Genetic marker in pathological processes (Review)

2010

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“…Two studiers were further excluded for not on the association between MMP1 rs1799750 polymorphism and lung cancer risk (Zhou et al, 2005;Sauter et al, 2008). Thus, 9 case-control studies with a total of 4823 cases and 4298 controls finally met the inclusion criteria and were included in the meta-analysis (Zhu et al, 2001;Fang et al, 2005;Su et al, 2006;Zhang et al, 2006; Cheng, 2007;Wei et al, 2007;Gonzalez-Arriaga et al, 2008;Hart et al, 2011;. The distribution of genotypes for MMP1 rs1799750 polymorphism in the controls of all studies was consistent with that expected from the HWE.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Of those 9 studies, sample sizes ranged from 146 to 3337, in which four studies focused on nonsmall cell lung cancer (NSCLC) and five ones on mixed lung cancers. There were four studies on Caucasians (Zhu et al, 2001;Su et al, 2006;Gonzalez-Arriaga et al, 2008;Hart et al, 2011), and five studies on Asians (Fang et al, 2005;Zhang et al, 2006;Cheng, 2007;Wei et al, 2007;. Almost all of the cases were histologically confirmed, while controls were mainly matched for sex and age.…”

Section: Study Characteristicsmentioning

confidence: 99%

MMP1 rs1799750 Single Nucleotide Polymorphism and Lung Cancer Risk: A Meta-analysis

Luo²

2012

Asian Pacific Journal of Cancer Prevention

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Background: Numerous studies have investigated the association of matrix metalloproteinase 1 (MMP1) rs1799750 single nucleotide polymorphism with lung cancer susceptibility, but the findings are inconsistent. Therefore, we performed a meta-analysis to comprehensively evaluate any possible association. Methods: We searched publications from MEDLINE, EMBASE and CNKI databases which assessed links between the MMP1 rs1799750 polymorphism and lung cancer risk. We calculated the pooled odds ratio (OR) and its 95% confidence interval (95%CI) using either fixed-effects or random-effects models.

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“…The selected SNPs were also previously analyzed in other cancers, such as lung, stomach, ovarian and bladder cancer. The results of these studies point to a positive correlation between MMPs polymorphism and the susceptibility to develop cancer, tumor invasiveness and further progression of the disease [22,23].…”

mentioning

confidence: 97%

Genetic polymorphism of matrix metalloproteinases in breast cancer

Wieczorek¹,

Reszka²,

Gromadzińska³

et al. 2012

neo

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The family of human matrix metalloproteinases (MMPs) consists of 24 zinc-and calcium-dependent proteolytic enzymes. MMPs are divided into six subgroups, in terms of differences in the substrate specificity with structural domain architecture. These enzymes are involved in many physiological processes, such as skeletal development, wound healing, scar formation, as well as carcinogenesis. MMPs, fulfilling its function of degradation of extracellular matrix components, are involved in one of the stages of angiogenesis enabling the development, growth and spread of the primary tumor. Therefore, the search for the common polymorphic variants of MMPs, new genetic markers as prognostic factors in breast cancer progress seems to be understandable.The minireview presents the results of 19 case-control or prospective studies concerning the association of SNPs of genes encoding nine MMPs: MMP-1, -2, -3, -7, -8, -9, -12, -13, -21 with the breast cancer risk, progression and survival. Key words: matrix metalloproteinases, genetic polymorphism, breast cancerBreast cancer, one of the leading civilization diseases, has for a number of years already focused attention of clinicians and researchers. It is the most commonly diagnosed cancer in women and is the major cause of death among female cancer patients. GLOBCAN estimates that, among the 12.7 million cancer cases worldwide in 2008, 2.9 million were women with breast cancer, and a million died of this cancer [1]. It is estimated that approximately 10% of the incidence of breast cancer is genetically-related and in most of the cases results from mutations in the genes BRCA1, BRCA2, p53, ATM. Attention should also be paid to a number of environmental factors related to diet and occupational exposure, including tobacco smoking, alcohol intake, obesity, shift work at night. Factors considered in the etiology of breast cancer include also endogenous hormonal factors, such as age of occurrence of menarche, menopause, number of births, and exogenous hormonal factors such as use of hormonal contraceptives or hormonal replacement [2,3]. Currently, a description of cancer cases includes clinical stage and Tumor Nodus Metastases (TNM) clinical classification, hormone receptor status and BRCA1, BRCA2 mutations. All these indicators are still not sufficient to predict the course of the cancer and, therefore, it is important to search for new markers that will enable the patient's prognosis and new predictive markers of cancer risk. As the majority of breast cancer deaths are caused by the invasion of cancer to other, sometimes distant organs, it is believed that it is appropriate to study the role of the enzyme gene polymorphisms that affect the process of angiogenesis largely responsible for the development, growth and metastatic capacity of the primary tumor. Key enzymes involved in these processes include the matrix metalloproteinases (MMPs) participating in an important stage of angiogenesis, namely the degradation of extracellular matrix (ECM) components.Matrix metalloproteinases. MM...

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Polymorphisms in the MMP1 and MMP3 promoter and non-small cell lung carcinoma in North China

Cited by 102 publications

References 27 publications

MMP-3 polymorphism: Genetic marker in pathological processes (Review)

MMP-3 polymorphism: Genetic marker in pathological processes (Review)

MMP1 rs1799750 Single Nucleotide Polymorphism and Lung Cancer Risk: A Meta-analysis

Genetic polymorphism of matrix metalloproteinases in breast cancer

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