Polymorphisms in the transforming growth factor‐β1 gene and the risk of asthma: A meta‐analysis

Abstract

Background and objective: Polymorphisms in the transforming growth factor-b1 (TGF-b1) gene have been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. A meta-analysis was performed to investigate the association between polymorphisms in the TGF-b1 gene and asthma susceptibility.

Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes

“…39 Furthermore, some of the genes we have studied are associated not only with COPD but also with asthma. [40][41][42] We cannot fully exclude that observed associations with lung function in our birth cohort might be ascribed to asthma. However, this is unlikely because none of the SNPs were associated with doctor-diagnosed asthma at age 8 years (data not shown).…”

CC16 Gene A38G Polymorphism and Susceptibility to Asthma: An Updated Meta-analysis

“…I 2 was also calculated to test heterogeneity among the included studies, with I 2 <25%, 25-75% and >75% considered to represent a low, moderate and high degree of heterogeneity, respectively (34). Publication bias was examined using Begg's funnel plot and Egger's test (35). All statistical analyses were completed using the Revman 5.1 (Nordic Cochrane Center, Copenhagen, Denmark) and STATA 10.0 (Stata Corporation, College Station, USA) software programs.…”

Association of transforming growth factor-beta 1 gene polymorphism with genetic susceptibility to ossification of the posterior longitudinal ligament in Korean patients

“…Thus, -509C may selectively downregulate TGF-β1 expression, and increased TGF-ß1 levels may be associated with -509T owing to the loss of negative regulation (Shah et al, 2006). The T allele of the -509C>T polymorphism has been associated with an increased risk of diseases such as endometriosis, asthma, and breast cancer (Zhang et al, 2010;Huang et al, 2011;Lee et al, 2011). Furthermore, the associations of the -509C>T polymorphism with bone mass or osteoporosis have been investigated, both alone and in combination with 869T>C polymorphism, but have yielded inconsistent or contradictory results (Yamada et al, 2001;Langdahl et al, 2003Langdahl et al, , 2008.…”