Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever

“…Therefore, as showed in Fig. 1, this meta-analysis finally included 28 eligible articles, containing 51 independent case-control studies (31 for the polymorphism rs4986790 and 20 for rs4986791)13141617181920212223242526272829303132333435363738394041. The characteristics of included studies are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

The relationship between toll like receptor 4 gene rs4986790 and rs4986791 polymorphisms and sepsis susceptibility: A meta-analysis

Wang

et al. 2016

Sci Rep

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Accumulating evidences have demonstrated that lipopolysaccharide (LPS) represents the important etiologic factor for sepsis. Some previous studies have reported the relationship between common polymorphisms rs4986790 and rs4986791 in the coding gene for this receptor and the susceptibility to sepsis, but there were distinct divergences between those findings. We therefore designed this meta-analysis incorporated 28 published articles containing 6,537 sepsis patients and 8,832 controls for a more comprehensive conclusion on this matter. Odds ratios (ORs) and 95% confidence interval (95% CIs) were calculated to evaluate the association of toll like receptor 4 gene polymorphisms rs4986790 and rs4986791 with sepsis risk. Heterogeneity between included studies was inspected using Q test, and sensitivity analysis was implemented via sequential deletion of each included study to investigate the stability of overall estimates. Funnel plot and Egger’s test were adopted to examine publication bias across selected studies. We found no significant association for either the polymorphism rs4986790 or rs4986791 with sepsis susceptibility in total analysis under any genetic models. Neither did we after combining these two polymorphisms. The results of this meta-analysis suggest that the rs4986790 and rs4986791 polymorphisms in toll like receptor 4 gene may have no statistically significant influence on sepsis susceptibility.

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“…Carriage of allele 2 in TLR4 Asp299Gly (A/G, rs4986790) and TLR4 Thr399Ile (C/T, rs4986791) has been correlated with Gram-negative sepsis [Yuan et al 2008;Lorenz et al 2002]. However, other studies did not confirm these results [Everett et al 2007;Yoon et al 2006 Heterozygosity associated with NTM lung disease (NTMLD) in Korean and Japanese cohorts [Tanaka et al 2007;Koh et al 2005…”

Section: Pattern Recognition Moleculesmentioning

confidence: 99%

Can immunogenetics illuminate the diverse manifestations of respiratory infections?

Affandi

Price

Waterer

2010

Ther Adv Respir Dis

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Improved technologies for high-throughput genotyping and the establishment of well-defined cohorts prompted hope that polymorphisms would be discovered that define a patients' risk of respiratory disease or aid in diagnosis. Genetic pitfalls encountered in this quest include genotyping errors, ethnic differences and linkage dysequilibrium. Differences in the definition of the disease phenotype also create discrepancies, so immunogenetic testing has not yet reached the clinic. However, associations between a polymorphism and a disease phenotype place the gene or one in linkage dysequilibrium on the path to the disease. Here we review studies of immune-related genes that are illuminating the immunopathogenesis of community-acquired pneumonia and mycobacterial infections.

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Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever

Cited by 20 publications

References 22 publications

Toll‐like receptors 2 and 4 gene polymorphisms in a southeastern Chinese population with tuberculosis

Toll‐like receptors 2 and 4 gene polymorphisms in a southeastern Chinese population with tuberculosis

The relationship between toll like receptor 4 gene rs4986790 and rs4986791 polymorphisms and sepsis susceptibility: A meta-analysis

Can immunogenetics illuminate the diverse manifestations of respiratory infections?

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