Polymorphisms of +2836 G&gt;A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population

Yang, Yu; Xu, Ji; Liu, Xiaoming; Zhou, Jian; Yang, Bin; Li, M.; Wang, Y.J.

doi:10.4238/2014.february.27.6

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…Utermann et al . [ 33 ] first reported that the presence of APOE polymorphisms has inspired widespread interest in the genetic associations between these single-nucleotide polymorphisms and many complex diseases including Alzheimer's disease,[ 34 ] type 2 diabetes,[ 35 ] hypertension,[ 36 ] and others. Besides, several studies have provided evidence that APOE is functional.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis for the Association of Apolipoprotein E ε2/ε3/ε4 Polymorphism with Coronary Heart Disease

Zhang

Tang

Peng

et al. 2015

Chinese Medical Journal

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Background:Coronary heart disease (CHD) is a multifactorial disease and is thought to have a polygenic basis. Apolipoprotein E (APOE) gene is one such candidate with its common ε2/ε3/ε4 polymorphism in CHD. In recent years, numerous case-control studies have investigated the relationship of APOE polymorphism with CHD risk. However, the results are confusing.Methods:To clarify this point, we undertook a meta-analysis based on 14 published studies including 5746 CHD cases and 19,120 controls. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for association using a random-effects or fixed-effects model using STATA version 10 (StataCorp LP, College Station, TX, USA).Results:Overall, the analysis showed that carriers of APOE ε2 allele decreased risk for CHD (ε2 allele vs. ε3 allele: OR = 0.82, 95% CI: 0.75–0.90, P < 0.001; ε2 carriers vs. ε3 carriers: OR = 0.81, 95% CI: 0.73–0.89, P < 0.001), compared with those carrying ε3 allele, especially in Caucasian population. However, those with ε4 allele had a significant increased risk for CHD (ε4 allele vs. ε3 allele: OR = 1.34, 95% CI: 1.15–1.57, P < 0.001), especially in Mongoloid population. Potential publication bias was observed in the genetic model of ε4 versus ε3, but the results might not be affected deeply by the publication bias. When we accounted for publication bias using the trim and fill method, the results were not materially alerted, suggesting the stability of our results.Conclusions:Taken together, our meta-analysis supported a genetic association between APOE gene and CHD. ε4 increased the risk of CHD, whereas ε2 decreased the risk of CHD.

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Section: Discussionmentioning

confidence: 99%

Meta-analysis for the Association of Apolipoprotein E ε2/ε3/ε4 Polymorphism with Coronary Heart Disease

Zhang

Tang

Peng

et al. 2015

Chinese Medical Journal

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“…And studies have shown that the polymorphism at the +2836 G>A site in the apoE gene is strongly correlated with the susceptibility to essential HTN in Hui people. [11] In addition, Hui people believe in Islam. Due to religious beliefs, they do not eat pork in their diet, mainly beef and mutton.…”

Section: Introductionmentioning

confidence: 99%

“…Hui people's genetic background, living environment, eating habits, religious belief, ethnic customs, and other factors are different from other population of China. And studies have shown that the polymorphism at the +2836 G>A site in the apoE gene is strongly correlated with the susceptibility to essential HTN in Hui people [11] . In addition, Hui people believe in Islam.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors of hypertension among Hui population in China

Zhang

Fan²,

et al. 2021

Medicine

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Background: Hypertension (HTN) has been considered as a health concern in developing countries. And Hui is a minority group with a large population in China. Its genetic background, inadequate access to health services, eating habits, religious belief, ethnic customs, and other factors differ from that of other ethnic groups, which may influence the prevalence of HTN. However, there is no current meta-analysis on the prevalence and risk factors of HTN among Hui population. Thus we conducted a systematic review aiming to estimate the pooled prevalence and risk factors of HTN among Hui population. Methods: PubMed, The Cochrane library, Web of science, CINAHL Complete, Weipu Database (VIP), China Knowledge Resource Integrated Database (CNKI), Wanfang Database, and SinoMed were systematically searched from inception to February 28, 2020 with publication language restricted to English and Chinese. We included cross-sectional, case–control, or cohort studies that focused on prevalence and risk factors of HTN among Hui population. Two investigators independently assessed the risk of bias of the studies included in the review using tools developed by JBI. Meta-analysis was conducted using Stata 12.0 software package. Results: Twenty-three studies were identified with a total of 30,565 study participants. The overall pooled prevalence of HTN was 28% (95% confidence interval [CI]: 24%–32%, I 2 = 98.8%, P < .001). Stratified by gender, the pooled prevalence of HTN in Hui was 26% (95%CI: 20%–33%, I 2 = 97.6%, P < .001) for males and 30% (95%CI: 23%–37%, I 2 = 98.3%, P < .001) for females. Pooled prevalence of HTN in Hui was 2% (95%CI: 2%–6%, I 2 = 70.6%, P = .065), 10% (95%CI: 3%–17%, I 2 = 83.7%, P < .001), 22% (95%CI: 12%–32%, I 2 = 87.9%, P < .001), 37% (95%CI: 20%–53%, I 2 = 94.0%, P < .001), 39% (95%CI: 24%–54%, I 2 = 97.7%, P < .001) and 42% (95%CI: 29%–56%, I 2 = 95.6%, P < .001) for those aged 18 to 29, 30 to 39, 40 to 49, 50 to 59, 60 to 69, and ≥70 years, respectively. Pooled prevalence of HTN in Hui was 22% (95%CI: 14%–29%, I 2 = 97.9%, P < .001) in urban areas and 23% (95%CI: 16%–30%, I 2 = 95.8%, P < .001) in rural areas. Daily salt intake (odd ratio [OR] = 3.94, 95%CI...

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“…In addition to the common APOE polymorphisms, other polymorphisms of APOE have also been reported in this relationship. APOE + 2836G>A polymorphism is associated with the susceptibility to hypertension [ 50 ]. An animal study has shown that the pathogenesis of hypertension in ApoE(−/−)/Cyp1b1(+/+) mice fed a high-fat diet is most likely due to oxidative stress caused by CYP1B1, as well as increased plasma lipid levels [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

APOE Genetic Polymorphism rs7412 T/T Genotype May Be a Risk Factor for Essential Hypertension among Hakka People in Southern China

Rao

et al. 2022

International Journal of Hypertension

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Objective. One of the causes of hypertension is a genetic factor. The purpose of this study was to look at the relationship between apolipoprotein E (APOE) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms and essential hypertension in the Hakka population. Methods. The study included 2,850 patients with hypertension and 2,034 controls. APOE rs429358, rs7412, and MTHFR rs1801133 were genotyped by polymerase chain reaction (PCR)-microarray. The differences in these polymorphisms between the two groups were analyzed. Results. The genotype and allele frequency of APOE and MTHFR polymorphisms did not differ significantly between hypertensive patients and controls. Patients with hypertension who were APOE rs429358C/C homozygous had higher TG, TC, LDL-C, and Apo-B levels, whereas patients with the T/T genotype had higher HDL-C levels. Patients with hypertension who were APOE rs7412T/T homozygous had higher TG and TC levels and lower LDL-C and Apo-B levels. Homocysteine (Hcy) levels in patients with MTHFR CC, CT, and TT genotypes were increased, while patients with the TT genotype and T allele had higher Hcy levels than those of patients with other genotypes and the C allele. The APOE rs7412T/T genotype in the co-dominant model (APOE rs7412T/T vs. C/C) (gender-, age-, smoking-, and drinking-adjusted OR 2.682, 95% CI, 1.072–6.710, P = 0.035 ) was a significant risk factor for hypertension. The APOE rs429358 and MTHFR rs1801133 genotypes in co-dominant, dominant, and recessive models were not significant risk factors for hypertension. Conclusions. It supports that APOE polymorphisms are related to hypertension in the Hakka population. Specifically, the APOE rs7412T/T genotype may be a risk factor for hypertension.

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Polymorphisms of +2836 G>A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population

Cited by 5 publications

References 38 publications

Meta-analysis for the Association of Apolipoprotein E ε2/ε3/ε4 Polymorphism with Coronary Heart Disease

Meta-analysis for the Association of Apolipoprotein E ε2/ε3/ε4 Polymorphism with Coronary Heart Disease

Prevalence and risk factors of hypertension among Hui population in China

APOE Genetic Polymorphism rs7412 T/T Genotype May Be a Risk Factor for Essential Hypertension among Hakka People in Southern China

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