Polymorphisms of −800G/A and +915G/C in TGF-β1 gene and lung cancer susceptibility

Qin, Di; Sun, Baohua; Jiang, Mingming; Du, Junfeng; Mai, Zhitao; Zhang, Xin; Zhou, Lean; Chi, Yumin; Lv, Jing

doi:10.3892/ol.2017.6173

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Grainger et al (1999) found that the rs1800469 SNP located in the promoter region is related to the expression level of TGF-b1. Di et al (2017) also found the SNP rs1800468 locus and the signal peptide rs1800471 locus also located in the promoter region are correlated with the expression level of TGF-b1 in plasma, and that specific alleles of these poly-morphisms were closely related to lung cancer susceptibility. Li et al (2019) also showed that the SNP located at the rs1800470 of the signal peptide of TGF-b1 gene is closely related to the occurrence of chronic obstructive pulmonary disease.…”

Section: Introductionmentioning

confidence: 85%

Association of Transforming Growth Factor β1 Gene Polymorphisms and Inflammatory Factor Levels with Susceptibility to Sepsis

Zheng¹,

Fu²,

Zhao

2021

Genetic Testing and Molecular Biomarkers

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To study the association of transforming growth factor b1 (TGF-b1) gene single nucleotide polymorphisms (SNPs) and plasma TGF-b1 levels with susceptibility to sepsis. Methods: The genotypes of the TGF-b1 gene rs1800469, rs1800468, rs1800470, and rs1800471 loci in 285 sepsis patients (119 patients with severe sepsis and 166 patients with mild sepsis) and 285 healthy individuals (control group) were analyzed through Sanger sequencing. Enzyme-linked immunosorbent assay was used to detect the levels of plasma inflammatory factors. Results: The TGF-b1 gene SNP rs1800469 C allele was 0.56 times lower than the T allele in terms of risk of susceptibility to sepsis (95% confidence interval [CI]: 0.43-0.72, p < 0.01). Carriers of the A allele at the rs1800468 locus of the TGF-b1 were 2.82 times more susceptible to sepsis than those with the G allele (95% CI: 1.62-4.91, p < 0.01). The T allele at the rs1800470 locus of TGF-b1 produced a lower risk of sepsis than those with the C allele (odds ratio [OR] = 0.74, 95% CI: 0.57-0.94, p = 0.02). The risk of susceptibility to sepsis in the TGF-b1 rs1800471 locus G allele was 3.54 times higher than that of C allele (95% CI: 2.14-5.86, p < 0.01). The TGF-b1 gene rs1800469 T > C and rs1800470 C > T were associated with mild sepsis, whereas rs1800468 G > A and rs1800471 C > G were associated with severe sepsis ( p < 0.01). The TGF-b1 gene rs1800469 T > C and rs1800470 C > T were associated with lower plasma TGF-b1 levels, whereas rs1800468 G > A and rs1800471 C > G were associated with higher TGF-b1 levels ( p < 0.05). Conclusion:The alleles T > C of rs1800469 and C > T of rs1800470 of the TGF-b1 gene were associated with lower plasma TGF-b1 levels and a reduced risk of sepsis susceptibility, whereas the alleles rs1800468 G > A and rs1800471 C > G were associated with higher TGF-b1 levels and risk of susceptibility to sepsis.

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Section: Introductionmentioning

confidence: 85%

Association of Transforming Growth Factor β1 Gene Polymorphisms and Inflammatory Factor Levels with Susceptibility to Sepsis

Zheng¹,

Fu²,

Zhao

2021

Genetic Testing and Molecular Biomarkers

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“…Finally, we obtained evidence of a correlation between adenocarcinoma in NSCLC and the single nucleotide polymorphism SNP. The results strongly imply that we have evaluated the association of two polymorphisms, including TGFβ1 (rs1800469) and (rs1800471), with pancreatic cancer risk in the Iranian population (47). Also, this study shows that high expression in the last stages of NS-CLC increases the concentration in the blood and the high mutation rate in TGFβ1 NSCLC patients.…”

Section: Discussionmentioning

confidence: 53%

“…TGFβ1 is a versatile cytokine that is vital for promoting local angiogenesis, extracellular matrix production, immunological evasion, cell heterogeneity adhesion, cell proliferation, invasion, metastasis, and other processes (8). Transforming growth factor β-induced protein is diffe-rentially expressed in transformed tissues.…”

Section: Introductionmentioning

confidence: 99%

TGFβ1, SMAD2, CTNNβ1, and Wnt3a gene mutational status and serum concentrations in individuals with non-small cell lung cancer

Hemn Abdalla Omer,

Kawa Amin

2023

Cell Mol Biol (Noisy-le-grand)

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The objective of the current investigation was to investigate the diagnostic utility of the serum concentrations and mutational status of TGFβ1, SMAD2, CTNNβ1, and Wnt3a. and the expression levels of human-related genes in patients with non-small cell lung cancer (NSCLC). The serum concentrations were determined using the ELISA technique, and PCR for genotype variations of TGFβ1, SMAD2, CTNNβ1, and Wnt3a were examined using Sanger sequencing in tissue samples obtained from 93 patients with NSCLC and 84 healthy individuals for blood, and 20 Formalin Fixed Paraffin Embedded (FFPE) from normal samples dissected adjacent to the tumour. The findings of the current investigation indicate that individuals diagnosed with NSCLC exhibited significant elevation in the serum levels of CEA and CYFRA21-1, as well as TGFβ1, SMAD2, CTNNβ1, and Wnt3a. In total, 325 mutations in four trialled genes (243 mutations in TGFβ1, 24 mutations in SMAD2,47 mutation Wnt3a and 11 mutations in CTNNβ1) were identified in patients with NSCLC. Furthermore, all mutations were recorded in adenocarcinoma, not squamous and normal adjacent tumour cells. CYFRA21-1 and CEA are more significant between NSCLC and HC, gender, and NSCLC types (p<0.001). In detail, TGFβ1 exhibited the highest rate of mutations among other genes and three types of genomic mutations. Elevated levels and genetic polymorphisms of TGFβ1, SMAD2, CTNNβ1, and Wnt3a may play crucial functions in the pathogenesis and angiogenesis of non-small cell lung cancer (NSCLC). These biomarkers might play a role in future immunologic response and pharmacologically targeted NSCLC therapy.

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Inherited alterations of TGF beta signaling components in Appalachian cervical cancers

Knobloch

Peng

Hade

et al. 2019

Cancer Causes Control

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Polymorphisms of −800G/A and +915G/C in TGF-β1 gene and lung cancer susceptibility

Cited by 4 publications

References 13 publications

Association of Transforming Growth Factor β1 Gene Polymorphisms and Inflammatory Factor Levels with Susceptibility to Sepsis

Association of Transforming Growth Factor β1 Gene Polymorphisms and Inflammatory Factor Levels with Susceptibility to Sepsis

TGFβ1, SMAD2, CTNNβ1, and Wnt3a gene mutational status and serum concentrations in individuals with non-small cell lung cancer

Inherited alterations of TGF beta signaling components in Appalachian cervical cancers

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