Polymorphisms of AMY1A gene and their association with growth, carcass traits and feed intake efficiency in chickens

Zhang, Zihao; Zhong, Haian; Lin, Shudai; Liang, Li; Ye, Shaopan; Xu, Zuowei; Ji, Congliang; Zhang, Zhe; Zhang, Dexiang; Zhang, Xiquan

doi:10.1016/j.ygeno.2020.10.041

Cited by 14 publications

(12 citation statements)

References 56 publications

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“…In this study, we reported 11 SNPs of the CD36 gene in the F2 resource group of yellow chickens, there are 2 SNPs located in the 5′ flanking regions, 8 SNPs located in the intron region, 1 SNPs located in the exon region. The results of Pearson correlation coefficients between traits displayed that most of the carcass traits had strong correlative with each other, which is consistent with the previous study ( Zhang et al, 2021 ). It is worth mentioning that the genetic correlation coefficients between skin yellowness traits and carcass traits were lower, therefore, it is difficult to selectively breed individuals with excellent skin yellowness using carcass characteristics.…”

Section: Discussionsupporting

confidence: 92%

Detection of CD36 gene polymorphism associated with chicken carcass traits and skin yellowness

Zhao¹,

Hu²,

Zhang³

et al. 2023

Poultry Science

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Section: Discussionsupporting

confidence: 92%

Detection of CD36 gene polymorphism associated with chicken carcass traits and skin yellowness

Zhao¹,

Hu²,

Zhang³

et al. 2023

Poultry Science

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“…Commonly identified regions by both iHS and ROH analysis harbored AMY2A , NTNG1 and VAV3 genes on GGA8. AMY2A encodes a member of the alpha-amylase family of proteins, which is involved in carbohydrates and glycogen metabolism, affecting growth, carcass traits and feed intake efficiency in chicken [ 37 ]. The previous report showed that AMY2A was under selection for metabolism, energy availability and response to thermal stress in African chickens [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Genome-wide run of homozygosity analysis reveals candidate genomic regions associated with environmental adaptations of Tibetan native chickens

Yuan

Sheng

et al. 2022

BMC Genomics

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Background In Tibet, the two most important breeds are Tibetan chicken and Lhasa white chicken, and the duo exhibit specific adaptations to the high altitude thereby supplying proteins for humans living in the plateau. These breeds are partly included in the conservation plans because they represent important chicken genetic resources. However, the genetic diversity of these chickens is rarely investigated. Based on whole-genome sequencing data of 113 chickens from 4 populations of Tibetan chicken including Shigatse (SH), Nyemo (NM), Dagze (DZ) and Nyingchi (LZ), as well as Lhasa white (LW) chicken breed, we investigated the genetic diversity of these chicken breeds by genetic differentiation, run of homozygosity (ROH), genomic inbreeding and selection signature analyses. Results Our results revealed high genetic diversity across the five chicken populations. The linkage disequilibrium decay was highest in LZ, while subtle genetic differentiation was found between LZ and other populations (Fst ranging from 0.05 to 0.10). Furthermore, the highest ROH-based inbreeding estimate (FROH) of 0.11 was observed in LZ. In other populations, the FROH ranged from 0.04 to 0.06. In total, 74, 111, 62, 42 and 54 ROH islands containing SNPs ranked top 1% for concurrency were identified in SH, NM, DZ, LZ and LW, respectively. Genes common to the ROH islands in the five populations included BDNF, CCDC34, LGR4, LIN7C, GLS, LOC101747789, MYO1B, STAT1 and STAT4. This suggested their essential roles in adaptation of the chickens. We also identified a common candidate genomic region harboring AMY2A, NTNG1 and VAV3 genes in all populations. These genes had been implicated in digestion, neurite growth and high-altitude adaptation. Conclusions High genetic diversity is observed in Tibetan native chickens. Inbreeding is more intense in the Nyingchi population which is also genetically distant from other chicken populations. Candidate genes in ROH islands are likely to be the drivers of adaptation to high altitude exhibited by the five Tibetan native chicken populations. Our findings contribute to the understanding of genetic diversity offer valuable insights for the genetic mechanism of adaptation, and provide veritable tools that can help in the design and implementation of breeding and conservation strategies for Tibetan native chickens.

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“…Complementary DNA (cDNA) synthesis for messenger RNA (mRNA) was carried out using the PrimerScript RT Reagent Kit with gDNA Eraser (Perfect Real Time) (Takara). Quantitative real-time PCR assays were conducted on QuantStudio 5 Real-Time PCR System (Applied Biosystems Inc., Foster, Waltham, MA, USA) using the iTaq Universal SYBR Green Supermix Kit (Bio-Rad Laboratories Inc., Hercules, CA, USA) in triplicate, as described previously [ 53 ]. The relative expression levels were calculated using the 2 − △△Ct relative quantitative method, as described previously [ 54 ].…”

Section: Methodsmentioning

confidence: 99%

Sox6 Differentially Regulates Inherited Myogenic Abilities and Muscle Fiber Types of Satellite Cells Derived from Fast- and Slow-Type Muscles

Zhang

Lin

Luo

et al. 2022

IJMS

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Adult skeletal muscle is primarily divided into fast and slow-type muscles, which have distinct capacities for regeneration, metabolism and contractibility. Satellite cells plays an important role in adult skeletal muscle. However, the underlying mechanisms of satellite cell myogenesis are poorly understood. We previously found that Sox6 was highly expressed in adult fast-type muscle. Therefore, we aimed to validate the satellite cell myogenesis from different muscle fiber types and investigate the regulation of Sox6 on satellite cell myogenesis. First, we isolated satellite cells from fast- and slow-type muscles individually. We found that satellite cells derived from different muscle fiber types generated myotubes similar to their origin types. Further, we observed that cells derived from fast muscles had a higher efficiency to proliferate but lower potential to self-renew compared to the cells derived from slow muscles. Then we demonstrated that Sox6 facilitated the development of satellite cells-derived myotubes toward their inherent muscle fiber types. We revealed that higher expression of Nfix during the differentiation of fast-type muscle-derived myogenic cells inhibited the transcription of slow-type isoforms (MyH7B, Tnnc1) by binding to Sox6. On the other hand, Sox6 activated Mef2C to promote the slow fiber formation in slow-type muscle-derived myogenic cells with Nfix low expression, showing a different effect of Sox6 on the regulation of satellite cell development. Our findings demonstrated that satellite cells, the myogenic progenitor cells, tend to develop towards the fiber type similar to where they originated. The expression of Sox6 and Nfix partially explain the developmental differences of myogenic cells derived from fast- and slow-type muscles.

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Polymorphisms of AMY1A gene and their association with growth, carcass traits and feed intake efficiency in chickens

Cited by 14 publications

References 56 publications

Detection of CD36 gene polymorphism associated with chicken carcass traits and skin yellowness

Detection of CD36 gene polymorphism associated with chicken carcass traits and skin yellowness

Genome-wide run of homozygosity analysis reveals candidate genomic regions associated with environmental adaptations of Tibetan native chickens

Sox6 Differentially Regulates Inherited Myogenic Abilities and Muscle Fiber Types of Satellite Cells Derived from Fast- and Slow-Type Muscles

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