Polymorphisms of apolipoprotein E in the Afro-descendant population of Buenaventura, Colombia

Perdomo, Vivian Andrea; Ortega, Diana; Barreto, Guillermo

doi:10.1016/j.rcp.2020.10.010

Cited by 1 publication

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“…ApoE4 is also a variant. It is associated with a high prevalence of Alzheimer's disease and hurts the recovery of function from various traumatic brain injuries.The long-lived gene E2 corresponds to the genotypes ε2/ε2 and ε2/ε3 and accounts for 7.8% of humans [9]. Individuals with this genotype are relatively less susceptible to AD, but their lipids show high triglycerides, low Lactate dehydrogenase C(LDH-C) and uncertain high-density lipoprotein (HDL).The wild-type gene E3 corresponds to the genotypes ε3/ε3 and ε2/ε4, which account for 70.8% of humans, and these are common genotypes.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between the Three Genes of Apolipoprotein E and the Hippocampus and Interference with Alzheimer's Disease

Lyu

2023

TNS

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Glycoproteins in the Apolipoprotein E (APOE) class have a role in controlling lipid metabolism. In astrocytes, microglia, vascular wall cells, and choroid plexus cells of the central nervous system, it is abundantly expressed. According to the rapid advancement of contemporary medicine, numerous investigations have demonstrated the existence of ApoE in chylomicron (CM), very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and certain high-density lipoprotein (HDL). ApoE has also been demonstrated to have a substantial impact on Alzheimer's disease (AD). To enhance the investigation of innovative medications and give researchers a theoretical foundation, research on ApoE is required in this area. Because damage to the hippocampus is a significant concern for the population in Alzheimer's research, we need to study the effects of ApoE on the hippocampus. This paper will discuss the relationship between age and sex of hippocampal atrophy after the ApoE gene has caused AD. The paper through a method of literature review and the analysis of some clinical cases explores the impact of the ApoE gene on health, followed by a comparison of the disease state before and after, as well as the clinical pattern of hippocampal atrophy, including a description of clinical symptoms. The paper finds that ApoE significantly impacts AD and that the hippocampus is significantly atrophied after the onset of Alzheimer's disease.

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Section: Introductionmentioning

confidence: 99%

The Relationship Between the Three Genes of Apolipoprotein E and the Hippocampus and Interference with Alzheimer's Disease

Lyu

2023

TNS

View full text Add to dashboard Cite

show abstract

Polymorphisms of apolipoprotein E in the Afro-descendant population of Buenaventura, Colombia

Cited by 1 publication

References 27 publications

The Relationship Between the Three Genes of Apolipoprotein E and the Hippocampus and Interference with Alzheimer's Disease

The Relationship Between the Three Genes of Apolipoprotein E and the Hippocampus and Interference with Alzheimer's Disease

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