Polymorphisms of COMT<i>Val158Met</i>and DAT1<i>3′-UTR VNTR</i>in Illicit Drug Use and Drug-Related Psychiatric Disorders

Chen, Chih‐Ken; Lin, Shih-Ku; Chiang, Shou Hao; Su, Lien-Wen; Wang, Liang‐Jen

doi:10.3109/10826084.2014.901391

Cited by 11 publications

(8 citation statements)

References 41 publications

(47 reference statements)

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“…According to Volkow et al, dopamine plays a critical role in the treatment of addictive disorders, 4 and Le Foll et al proposed that a genetic study should evaluate this role 5 . Moreover, the catechol‐O‐methyltransferase (COMT) polymorphism considerably affects the treatment of substance and behavioral addictions 6,7 . Nonetheless, its association with IGD needs further evaluation.…”

Section: Introductionmentioning

confidence: 99%

“…Compared with the Val allele, the Met allele is more associated with lower COMT enzyme activity, lower dopamine degradation, and higher synaptic dopamine 8 ; consequently, the Met allele is associated with more efficient frontal lobe functions 9 . Catechol compounds and the frontal lobes, associated with cognition, have major roles in various psychiatric disorders, including addictive disorders 6,7 …”

Section: Introductionmentioning

confidence: 99%

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Association of Internet gaming disorder with catechol‐O‐methyltransferase: Role of impulsivity and fun‐seeking

Yen

Lin

et al. 2021

The Kaohsiung J of Med Scie

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Dopamine functioning is an essential mechanism underlying addictive behaviors. This paper evaluates the association of Internet gaming disorder (IGD) with the catechol‐O‐methyltransferase (COMT) val158met polymorphism and examines the roles of impulsivity and reinforcement sensitivity in this association. Using diagnostic interviews, this study recruited 69 participants with IGD and 138 participants without. All participants underwent diagnostic interviews for IGD and an evaluation for the COMT val158met polymorphism, impulsivity, and reinforcement sensitivity. Among participants with the Val/Val genotype, the odds ratio (95% confidence interval) for IGD was 2.09 (1.15–3.80). The IGD–Val/Val genotype association was mediated by impulsivity and fun‐seeking. The Val/Val genotype is indicative of low frontal functioning and is a predictive factor of IGD, with this effect being confounded by impulsivity and fun‐seeking. Interventions targeting impulsivity and fun‐seeking might attenuate the risk of IGD, particularly among individuals with the Val/Val genotype. Additional studies are necessary to elucidate the possible role of dopamine functioning.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Internet gaming disorder with catechol‐O‐methyltransferase: Role of impulsivity and fun‐seeking

Yen

Lin

et al. 2021

The Kaohsiung J of Med Scie

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“…Since dopamine is the main neurotransmitter involved in the reward pathway, genes related with dopamine synthesis, degradation, receptors, and transporters are possible research topics [13]. In this context, the COMT Val 158 Met (rs4680) polymorphism has been studied in the scope of drug addiction with evidence of a signi cant correlation in drug addicted patients [14,15]. The COMT Val 158 Met polymorphism determines the dopamine concentration in the prefrontal cortex (PFC), but not in the striatum [16].…”

Section: Introductionmentioning

confidence: 99%

Catechol-O-Methyltransferase Activity in Individuals with Substance Use Disorders: A Case Control Study

Azevedo

Carvalho

Serrão

et al. 2021

Preprint

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Background Impulsivity and substance use disorders (SUD) can be related to the same environmental factors. In this study, we intended to evaluate the dopaminergic function in imprisoned SUD offenders through the determination of s-COMT activity. Methods The study included 46 male individuals from a Portuguese penal institution. The participants were assessed through a battery of standardised instruments: Psychopathy Checklist-Revised (PCL-R), Barratt Impulsivity Scale Version 11 (BIS-11), and the European version of the Addiction Severity Index (EuropASI). s-COMT erythrocyte activity was evaluated. Results Overall, 73.9% (n=34) of the individuals had Antisocial Personality Disorder (ASPD) and 58.7% (n=27) presented SUDs. We evidenced, for the first time, that, in SUD individuals, s-COMT activity is correlated with the severity of drug dependence (EuropASI) (p<0.05), and with BIS-11 factors self-control (p<0.0001) and non-planning (p=0.002). Conclusions This study opens new perspectives regarding the pharmacological intervention on drug dependence through the interference on dopamine pathways.

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“…Differences in catechol-o-methyl transferase (COMT) genotype have been linked to illicit drug use (Chen et al, 2014) and polysubstance abuse (Vandenbergh et al, 1997). However, with regard to alcohol use, the role of COMT is unclear.…”

Section: Introductionmentioning

confidence: 99%

Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats

McCane

DeLory

Timm

et al. 2018

Alcohol

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Polymorphisms of the catechol-O-methyl transferase (COMT) gene have been associated with alcoholism, suggesting that alterations in the metabolism of catecholamines may be a critical component of the neuropathology of alcoholism. In the current experiments, the COMT inhibitor tolcapone was utilized in an operant behavioral model of reinforcer-seeking and drinking to determine if this compound was capable of remediating the excessive seeking and drinking phenotype of the alcohol-preferring P rat. Tolcapone was administered to male and female alcohol-reinforced P and Wistar rats. Additionally, tolcapone was administered to male sucrose-reinforced P and Wistar rats to determine if its effects also extended to a natural reinforcer. Animals were trained to make an operant response that resulted in 20 min uninterrupted access to the reinforcer solutions. Tolcapone had no effect in female rats on either seeking or consumption of ethanol. However, reductions of both reinforcer seeking and consumption were observed in male P rats, but only of seeking in Wistars. In separate experiments, using reinforcer naïve male and female animals, COMT expression was assessed via Western Blot analysis. Sex differences in COMT expression were also observed, where male P rats exhibited a marked reduction in protein expression relative to females in the PFC. Sex differences were not observed for Wistars or in the striatum and hippocampus. These data complement our previous findings in which tolcapone reduced cue-evoked responses in P rats and further suggest clinical utility of COMT inhibitors in the treatment of addiction disorders, specifically in male high drinkers.

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Polymorphisms of COMTVal158Metand DAT13′-UTR VNTRin Illicit Drug Use and Drug-Related Psychiatric Disorders

Cited by 11 publications

References 41 publications

Association of Internet gaming disorder with catechol‐O‐methyltransferase: Role of impulsivity and fun‐seeking

Association of Internet gaming disorder with catechol‐O‐methyltransferase: Role of impulsivity and fun‐seeking

Catechol-O-Methyltransferase Activity in Individuals with Substance Use Disorders: A Case Control Study

Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats

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