Polymorphisms of CYP1A1, GSTM1 and GSTT1 Loci as the Genetic Predispositions of Oral Cancers and Other Oral Pathologies: Tobacco and Alcohol as Risk Modifiers

Chatterjee, Sumana; Dhar, Soujatya; Sengupta, Bani; Ghosh, Ashish; De, Manas; Roy, S. K.; Chakrabarti, S.

doi:10.1007/s12291-010-0057-3

Cited by 13 publications

(6 citation statements)

References 28 publications

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“…This is the first study to report an interaction of CYP1A1 T3801C polymorphism and environmental factors in the development of HNC in northeast Indian population. Similar type of result, have been reported in the previous other study in oral cancers (Chatterjee et al, 2009;Chatterjee et al, 2010). On the other hand, individual carrying the CYP1A1 TC and CC genotypes and taking alcohol either with smoking or tobacco-betel quid chewing has an overall higher risk for HNC risk.…”

Section: Discussionsupporting

confidence: 89%

Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India

Singh

Choudhury²,

Kapfo³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 89%

Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India

Singh

Choudhury²,

Kapfo³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Another sixteen studies were excluded as one of them presented overlapping data (44) and 15 failed to provide sufficient genotyping data (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59). In addition, there were five studies excluded as the cases were diagnosed as oral cancer only, and the identification of OSCC was not confirmed (60)(61)(62)(63)(64). One study was excluded as the study only contained the cases and lacked the controls (65).…”

Section: Resultsmentioning

confidence: 99%

CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta-analysis

Xie

Luo²,

Shan

et al. 2016

Molecular and Clinical Oncology

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Numerous case-control studies have investigated whether the gene polymorphism is involved in the occurrence of oral squamous cell carcinoma (OSCC); however, the conclusions are inconsistent. In order to further explore the correlation and obtain a strong conclusion, a meta-analysis was performed to systematically assess the association between the MspI polymorphism and risk of OSCC. In the present meta-analysis, the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were used to assess the association. The statistical analyses were performed with STATA 11.0 software. The heterogeneity was assessed by Q test and Itest. The final analysis included 10 studies of 1,505 cases and 1,967 controls. The overall results suggested that the MspI polymorphism was significantly associated with an increased risk of OSCC (CC+TC vs. TT: OR, 1.31; 95% CI, 1.01-1.70; P=0.043; CC vs. TC+TT: OR, 2.38; 95% CI, 1.58-3.58; P<0.001; CC vs. TT: OR, 2.52; 95% CI, 1.60-3.96; P<0.001; and C vs. T: OR, 1.45; 95% CI, 1.15-1.83; P<0.001). In a stratified analysis by ethnicity, a statistically significant correlation existed in the Asian population, but not mixed-race and Caucasian populations. In conclusion, despite several limitations, the present meta-analysis established that the MspI polymorphism may be a risk factor for OSCC, particularly among the Asian population.

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“…There appeared to be major differences in the frequency distribution of genotypes of CYP1A1*2A in our population when compared to the Northern (Singh et al , ) and North‐Eastern (Chatterjee et al , ) regions of India. For the results of CYP1A1*2C, the distribution pattern was almost similar in all the geographic regions (Sam et al , ; Ruwali and Parmar, ; Sabitha et al , ).…”

Section: Discussionmentioning

confidence: 61%

Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from Gujarat, West India

et al. 2013

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Polymorphic variability in the enzymes involved in biotransformation of tobacco-related pro-carcinogens plays an important role in modulating oral cancer susceptibility. CYP1A1*2A, CYP1A1*2C, GSTM1 and GSTT1 polymorphisms were determined in 122 oral carcinoma cases and 127 controls from Gujarat, West India using PCR-based methods. The results revealed that the polymorphic variants of CYP1A1 gene did not show association towards oral cancer risk. The GSTM1 and GSTT1 null genotypes were found to be over-represented in patients than controls, suggesting a moderate increase in risk of oral cancer. The oral cancer risk was significantly increased in the patients having either alone or concurrent deletion of GSTM1 and GSTT1. The results also suggested significant association between tobacco habits, especially chewing, variant genotypes of CYP1A1, GSTM1 and GSTT1 and oral cancer risk. Our data have provided evidence that GST polymorphism modified the susceptibility to oral cancer and individuals with variant genotypes of the three genes with tobacco habits are at significant risk of developing oral cancer.

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Polymorphisms of CYP1A1, GSTM1 and GSTT1 Loci as the Genetic Predispositions of Oral Cancers and Other Oral Pathologies: Tobacco and Alcohol as Risk Modifiers

Cited by 13 publications

References 28 publications

Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India

Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India

CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta-analysis

Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from Gujarat, West India

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