Polymorphisms of Estrogen Receptor-α and Estrogen Receptor-β Genes and its Expression in Endometriosis

Abstract

Objectives: Endometriosis is a common gynecological disorder, characterized by the presence of endometrial-like tissue in extrauterine location. Increases of estradiol concentration can influence the risk of endometriosis and activity of estrogen receptors. Polymorphism in estrogen receptors (ER) cause the alteration of gene expression and influence the interaction hormone-receptors. This research aimed to determine the role of estrogen and genetic aspect of ER in the pathogenesis of endometriosis. Materials and Methods:This research is a case-control study comparing 83 women with endometriosis and 76 women without endometriosis for polymorphisms, but for RE gene expression analysis and estrogen level measurement using samples obtained from 18 women with endometriosis and 18 women without endometriosis. Polymorphism was determined with PCR-RFLP. Data were analyzed by Chi-square, Mann-Whitney, Spearman rho, tindependent, a two-tailed.