Polymorphisms of estrogen receptor-α gene in Brazilian women with high breast density after menopause

Souza, Marilene Alícia; Fonseca, Ângela Maggio da; Bagnoli, Vicente Renato; Barros, Nestor de; Franzolin, Solange Oliveira Braga; Carvalho, Kátia Cândido; Soares-Jr, José Maria; Baracat, Edmund Chada

doi:10.3109/09513590.2013.801438

Cited by 2 publications

(4 citation statements)

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“…The allele frequencies of ERα-PvuII and ERα-XbaI in both groups were similar to those reported in previous studies [16,17,20,[27][28][29].…”

Section: Resultssupporting

confidence: 89%

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Polymorphisms in the Estrogen Receptor Alpha Gene and Mammographic Density Result Study in Brazilian Women

Souza¹,

Fonseca²,

Bagnoli³

et al. 2013

J Cancer Sci Ther

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This article presents the results of the case-control study in the city of São Paulo, that examined the association of the polymorphisms in the genes ERα-PvuII and ERα-XbaI with the risk of high mammographic density after menopause. The associations of these polymorphisms with other risk factors for breast cancer were also evaluated. MethodsCase-control study that included 308 women with HMD(for more than 50% density) and 155 controls(to 50% density or less) evaluated by computerized objective method [25], aged 45-65, without menstruation or hormone therapy for at least 1 year, without previous BC and ovarian cancer. Initially, the patients were selected in a subjective way by the standard ACR-BIRADS ® , by a unique reader (the head

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“…The allele frequencies of ERα-PvuII and ERα-XbaI in both groups were similar to those reported in previous studies [16,17,20,[27][28][29].…”

Section: Resultssupporting

confidence: 89%

“…The distributions of selected demographic characteristics that are the main risk factors for breast cancer are presented in Table 3. It was observed elevated risk of HMD for the main risk factors that have been reported in other previous studies [20,16].…”

Section: Resultssupporting

confidence: 75%

Polymorphisms in the Estrogen Receptor Alpha Gene and Mammographic Density Result Study in Brazilian Women

Souza¹,

Fonseca²,

Bagnoli³

et al. 2013

J Cancer Sci Ther

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“…Fragment analysis was performed in 1% agarose gel stained with ethidium bromide, and the bands were separated and photographed under ultraviolet light. The PCR and RFLP conditions utilized followed the protocol of Souza et al [ 16 , 17 ]. The restriction enzymes and the base pair (bp) sizes for the normal and variant alleles are summarized in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

“…For polymorphisms, the Hardy-Weinberg (H-W) equilibrium was calculated. The Power Calculation of 80% was 70 patients per group based on the early menarche age frequency of Pvull/Xbal and high risk of breast cancer [ 16 , 17 ]. The analyses were carried out with the SPSS version 16.0 software.…”

Section: Methodsmentioning

confidence: 99%

Analysis of the PvuII and XbaI polymorphisms in the estrogen receptor alpha gene in girls with central precocious puberty: a pilot study

et al. 2018

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BackgroundPrecocious puberty (PP) is defined as premature pubertal development. Its consequences surpass the physical evidence of sexual maturity with the premature epiphyseal closure of the long bones and the reduction of adult stature by varied degrees. Central PP is characteristically dependent on GnRH and most of its causes are not completely known. Altered estrogen action is also believed to be involved in the genesis of PP. In fact, estrogen receptor alpha (Rea) gene polymorphisms may be associated with early age at menarche. The objective of this study was to investigate the relationship between Reα gene polymorphisms (PvuII and XbaI) and the occurrence of central PP.MethodsA total of 73 girls with central PP and 101 girls with normal pubertal maturation were evaluated. Both groups were genotyped for the PvuII (T/C) and XbaI (A/G) polymorphisms in the Reα gene.ResultsThe frequency distribution of the XbaI (p = 0.28) and of the PvuII (p = 0.12) genotypes, as well as the XbaI and PvuII allelic variants (p = 0.23 and p = 0.86, respectively), did not differ between the groups.ConclusionThe PvuII and XbaI Rea gene polymorphisms do not appear to be related to development of central PP.Electronic supplementary materialThe online version of this article (10.1186/s12881-018-0577-x) contains supplementary material, which is available to authorized users.

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Polymorphisms of estrogen receptor-α gene in Brazilian women with high breast density after menopause

Abstract: Allelic and genotypic distribution similar to literature. The risk factors for BC were more prevalent in women with high breast density but without significant associations with these polymorphisms.

Cited by 2 publications

References 18 publications

Polymorphisms in the Estrogen Receptor Alpha Gene and Mammographic Density Result Study in Brazilian Women

Polymorphisms in the Estrogen Receptor Alpha Gene and Mammographic Density Result Study in Brazilian Women

Analysis of the PvuII and XbaI polymorphisms in the estrogen receptor alpha gene in girls with central precocious puberty: a pilot study

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