Polymorphisms of Folate-Metabolizing Enzymes (MTHFR, MTR and MTRR) and Colorectal Cancer Risk: An Updated Systematic Review and Meta-analysis of Case-control Studies

Abstract

Review question / Objective: Is there an association between gene polymorphisms in MTHFR, MTR and MTRR genes and colorectal cancer risk ? Rationale: Several lines of evidence based on case-control studies suggest that MTHFR, MTR, and MTRR polymorphisms may increase the risk of colorectal cancer in the general population. To increase power and precision as well as to appraise the polished literature, we conducted this INPLASY 1