2012
DOI: 10.1016/j.humimm.2012.05.003
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Polymorphisms of genes related to endothelial cells are associated with primary biliary cirrhosis patients of Cretan origin

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Cited by 16 publications
(14 citation statements)
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“…A possible explanation is that vascular damage was caused by PBC itself, although it is also possible that the symptoms of Raynaud's phenomenon were too mild to be noticed by these patients. Previous studies have suggested a role of endothelin in decreased antioxidant capacity and impaired vascular endothelial cell function or microcirculation in PBC . The relationships between these factors and finger nail fold capillary abnormalities in PBC patients should be examined in future studies.…”
Section: Discussionmentioning
confidence: 97%
“…A possible explanation is that vascular damage was caused by PBC itself, although it is also possible that the symptoms of Raynaud's phenomenon were too mild to be noticed by these patients. Previous studies have suggested a role of endothelin in decreased antioxidant capacity and impaired vascular endothelial cell function or microcirculation in PBC . The relationships between these factors and finger nail fold capillary abnormalities in PBC patients should be examined in future studies.…”
Section: Discussionmentioning
confidence: 97%
“…The cohort of the Cretan RA patients analyzed in the present work is a part of the Hellenic Biologic Registry for Rheumatic Diseases that collects data from all patients who receive biologic agents in 7 Rheumatology Centers of Greece. Considering that independent replication is required to confirm definitively the association of SNPs with response to anti-TNF therapy, we performed the present study focusing on the genetic homogeneous population of Crete, which shares a common genetic and cultural background and a common environment, while it is characterized by good genealogical and clinical records and low migration rates, thus contributing to an increased reliability of the data collected [2325]. However, our study failed to detect any association between seven SNPs and response to anti-TNF therapy.…”
Section: Discussionmentioning
confidence: 99%
“…In addition we reported that polymorphisms related to endothelial cells were associated with PBC. Both eNOS intron4 VNTR and eNOS exon7 G894T SNP were related to increased risk in PBC while endothelin-1 rs2071942 ''A'' and rs5370 ''T'' alleles had a tendency for association with disease progression [190] . Bile ducts are supplied with blood only from hepatic arteries; the epithelial cells receives blood from a network of capillaries originating from the terminal branches of the hepatic artery.…”
Section: Pathogenesis Of Pbc: a Unifying Hypothesismentioning
confidence: 95%