Polymorphisms of interleukin-8 and -18 genes and diabetic retinopathy

Cilenšek, Ines; Hercegovac, Amela; Terzić, Rifet; Petrovič, Mojca Globočnik; Petrovič, Daniel

doi:10.2478/s11535-010-0038-9

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…By excluding patients with recent vitreous haemorrhage, by demonstrating the absence of differences in vitreous levels of IL‐8 and VEGF between patients with and those without haematovitreous (Table 3) and according to our previous studies (Cilenšek et al. 2010; Petrovic et al.…”

Section: Discussionmentioning

confidence: 97%

Association of preoperative vitreous IL‐8 and VEGF levels with visual acuity after vitrectomy in proliferative diabetic retinopathy

Petrovič

Korošec

Košnik

et al. 2010

Acta Ophthalmologica

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Acta Ophthalmol. 2010: 88: e311–e316 Abstract. Purpose: To determine whether the vitreous levels of interleukin 8 (IL‐8) and vascular endothelial growth factor (VEGF) of patients with proliferative diabetic retinopathy (PDR) were associated with poor visual acuity after vitrectomy. Methods: Observational cross‐sectional study. Patient clinical characteristics and preoperative eye characteristics (63 eyes): visual acuity, iris neovascularization, vitreous haemorrhage, macular detachment, macular oedema, active retinal neovascularization, neovascularization of the disc, burned out PDR (defined as natural end stage of PDR with inactive membranes without previously performed laser photocoagulation) and panretinal photocoagulation were registered prior to vitrectomy for each patient. Vitreous VEGF and IL‐8 levels were measured using the cytometric bead array method. Poor postoperative visual acuity was defined as visual acuity of <20/200 and was checked 2 years after vitrectomy. Results: Twenty‐one of the 63 eyes (33.3%) had poor visual acuity after vitrectomy. Univariate analysis showed that vitreous levels of IL‐8, the absence of panretinal photocoagulation, preoperative macular detachment and poor preoperative visual acuity were significantly associated with poor final visual acuity after vitrectomy. A stepwise multiple logistic regression analysis showed that elevated vitreous levels of IL‐8 (p < 0.0001), macular detachment (p = 0.011) and the absence of panretinal photocoagulation (p = 0.03) were independent predictors for poor visual outcome. Conclusions: Elevated vitreous IL‐8 level could either be a marker of ischaemic inflammatory reaction, or it could play a role in deteriorating visual acuity by DR progression or both. Further studies are needed to provide better understanding of IL‐8 and inflammation involvement in visual prognosis in PDR.

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Section: Discussionmentioning

confidence: 97%