Polymorphisms of TGFBR1, TLR4 are associated with prognosis of gastric cancer in a Chinese population

He, Bangshun; Xu, Tan; Pan, Bei; Pan, Yuqin; Wang, Xuhong; Dong, Jingwu; Sun, Huiling; Xu, Xueni; Liu, Xiangxiang; Wang, Shukui

doi:10.1186/s12935-018-0682-0

Cited by 27 publications

(24 citation statements)

References 29 publications

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“…Sepahi et al found that rs334348 functional variants were associated with endometriosis severity . Additionally, no association between rs334348 polymorphism and clinical outcomes of gastric cancer patients was also reported . The present prospective study with large‐scale sample size suggested a significantly and independently association between rs334348 polymorphism and the better DSS of oral cancer.…”

Section: Discussioncontrasting

confidence: 49%

“…This pathway is vital in the development and progression of malignancy by regulating cellular proliferation and differentiation . Previous researches have shown that genetic polymorphism and aberrant expression of TGFBR1 were associated with prognosis of several digestive tract cancers, including gastric cancer and colorectal cancer . Additionally, a recent study also demonstrated that higher TGFBR1 expression may represent poor prognosis in advanced head and neck squamous cell carcinomas (HNSCC) .…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of transforming growth factor beta receptor 1 polymorphisms in patients with oral cancer

Chen

Wang

et al. 2019

J Oral Pathology Medicine

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Objective: To investigate possible associations between disease-specific survival (DSS) of oral cancer and single nucleotide polymorphisms (SNPs) in transforming growth factor beta receptor 1 (TGFBR1). Methods:Using iPLEX Sequenom MassARRAY platform, three SNPs in TGFBR1 gene were genotyped in 356 newly diagnosed patients with histologically confirmed primary oral cancer. Demographic and clinical information of all cases were obtained from face-to-face interviews and electronic medical records, and telephone interviews were carried out every 6 months to timely gain follow-up data. Univariate and multivariate Cox proportional hazards model were used to assess the association between the polymorphisms of tagging loci and DSS of oral cancer.Results: TGFBR1 rs33438 polymorphism was protective against death of oral cancer in codominant (AG vs AA: HR = 0.55, 95% CI = 0.35-0.88) and dominant (GG + AG vs AA: HR = 0.57, 95% CI = 0.38-0.87) models. Moreover, better DSS was particularly significant in radiotherapy patients who carrying GG + AG genotype. There also existed a positive multiplicative interaction on DSS between the polymorphism of TGFBR1 rs334348 and radiotherapy (P = .001). Not any associations between TGFBR1 rs334354 or rs3739798 polymorphism and DSS were observed.Conclusions: This preliminary prospective study suggests that polymorphism of TGFBR1 rs334348 may act as a potentially independent factor and novel genetic biomarker to predict oral cancer DSS especially for patients with radiotherapy. A much more extensive investigation will need to confirm our findings. K E Y W O R D Soral cancer, prospective study, radiotherapy, TGFBR1

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Section: Discussioncontrasting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Prognostic value of transforming growth factor beta receptor 1 polymorphisms in patients with oral cancer

Chen

Wang

et al. 2019

J Oral Pathology Medicine

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“…Some studies have demonstrated that TGF-β1 expression is increased in prostate cancer ( 46 ), ovarian cancer ( 47 ), hepatocellular carcinoma ( 12 ), bladder cancer ( 48 ), breast cancer ( 49 ) and cholangiocarcinoma ( 50 ), suggesting that abnormal TGF-β1 expression can influence tumor invasiveness and result in a poor prognosis. Regarding TGF-βR1, a previous study has found that it promotes tumor angiogenesis by upregulating matrix metalloproteinase 9 in metastatic human melanoma cells ( 51 ) Moreover, changes in TGF-βR have been observed in numerous types of human tumors, such as breast ( 52 , 53 ), colon ( 54 ) and gastric cancer ( 20 ), and are characterized by gene mutations, decreased levels or inactivation of TGF-βR. TGF-βR1 mutations have been reported in malignant tumors of the ovary, breast and pancreas, as well as in colon cancer ( 16 , 52 - 56 ).…”

Section: Tgf-β Tgf-βr1 and Malignant Tumorsmentioning

confidence: 99%

“…Mutant cells that lack TGF-βR1 do not respond to TGF-β1, which further affects the transduction of the TGF-β signaling pathway ( 16 , 17 ). Additionally, the activation or overexpression of TGF-βR1 is observed in different types of tumor and can serve an important role in tumor cell proliferation and migration to other tissues by taking part in EMT ( 18 ), such as in colon ( 19 ) and gastric cancer ( 20 ). Previous studies ( 20 - 22 ) have revealed that TGF-βR1 is observed in different types of tumor and serves an important role in tumor metastasis by participating in cancer development, cell migration and blood vessel regeneration, leading to unsatisfactory responses to treatment.…”

Section: Introductionmentioning

confidence: 99%

Role and clinical significance of TGF‑β1 and TGF‑βR1 in malignant tumors (Review)

et al. 2021

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The appearance and growth of malignant tumors is a complicated process that is regulated by a number of genes. In recent years, studies have revealed that the transforming growth factor-β (TGF-β) signaling pathway serves an important role in cell cycle regulation, growth and development, differentiation, extracellular matrix synthesis and immune response. Notably, two members of the TGF-β signaling pathway, TGF-β1 and TGF-β receptor 1 (TGF-βR1), are highly expressed in a variety of tumors, such as breast cancer, colon cancer, gastric cancer and hepatocellular carcinoma. Moreover, an increasing number of studies have demonstrated that TGF-β1 and TGF-βR1 promote proliferation, migration and epithelial-mesenchymal transition of tumor cells by activating other signaling pathways, signaling molecules or microRNAs (miRs), such as the NF-κB signaling pathway and miR-133b. In addition, some inhibitors targeting TGF-β1 and TGF-βR1 have exhibited positive effects in in vitro experiments. The present review discusses the association between TGF-β1 or TGF-βR1 and tumors, and the development of some inhibitors, hoping to provide more approaches to help identify novel tumor markers to restrain and cure tumors.

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“…To achieve this aim, gene association studies are required as personalized information to predict the disease outcomes. Single nucleotide polymorphisms (SNPs) in the TLR4 gene were associated with both infectious diseases and non-communicable diseases [22][23][24]. To date, several positions of TLR4 polymorphisms have been examined for proposal as risk or protective factors of glaucoma.…”

Section: Introductionmentioning

confidence: 99%

The association of toll-like receptor 4 gene polymorphisms with primary open angle glaucoma susceptibility: a meta-analysis

Chaiwiang

Poyomtip

2019

Bioscience Reports

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Primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) cause irreversible blindness while current medications cannot completely inhibit disease progression. An understanding of immunopathogenesis is thus a keystone to develop novel drug targets and genetic markers are still required for early diagnosis. Toll-like receptor 4 (TLR4) is an essential player in inflammation in various diseases. However, the TLR4 polymorphisms have not been completely elucidated in both types of glaucoma. The aim of the present study was to identify the association between TLR4 polymorphism and glaucoma (POAG and NTG) via the use of a comprehensive review and meta-analysis. The relevant studies were collected from PubMed, Excerpta Medica Database (EMBASE), and Web of Science to identify eight included articles, assessed for quality by a modified Newcastle-Ottawa Scale (NOS) for gene association study. A meta-analysis was applied to calculate the pooled odds-ratio and 95% confidence intervals (CIs) to evaluate the association between TLR4 polymorphism and glaucoma. The results revealed that TLR4 rs1927911 A/G, rs12377632 C/T, and rs2149356 G/T significantly decrease the risk of POAG and NTG in allele contrast models 0.71-, 0.71-, and 0.67-fold, respectively. Moreover, rs4986790 A/G and rs4986791 C/T showed a stringent association with POAG in allele contrast, heterozygous, recessive, and overdominant models. In conclusion, this meta-analysis represented a significant correlation between TLR4 polymorphisms and both types of glaucoma suggesting that TLR4 might be involved in the pathogenesis of glaucoma and may be applied as a genetic marker for disease screening.

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Polymorphisms of TGFBR1, TLR4 are associated with prognosis of gastric cancer in a Chinese population

Cited by 27 publications

References 29 publications

Prognostic value of transforming growth factor beta receptor 1 polymorphisms in patients with oral cancer

Prognostic value of transforming growth factor beta receptor 1 polymorphisms in patients with oral cancer

Role and clinical significance of TGF‑β1 and TGF‑βR1 in malignant tumors (Review)

The association of toll-like receptor 4 gene polymorphisms with primary open angle glaucoma susceptibility: a meta-analysis

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