Polymorphisms of the antiapoptotic protein bag3 may play a role in the pathogenesis of tako-tsubo cardiomyopathy

Citro, Rodolfo; d’Avenia, Morena; Marco, Margot De; Giudice, Roberta; Mirra, M.; Ravera, Amelia; Silverio, Angelo; Farina, Rosario; Silvestri, Francesco; Gravina, Paolo; Villa, Francesco; Puca, Annibale Alessandro; Windt, León J. De; Laurenzi, Vincenzo De; Bossone, Eduardo; Turco, Maria Caterina; Piscione, Federico

doi:10.1016/j.ijcard.2013.03.050

Cited by 28 publications

(27 citation statements)

References 14 publications

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“…Furthermore, a genetic background is imaginable. For instance, alterations in the gene for BAG3 (bcl2‐associated athanogene 3) are held responsible for the occurrence of cancer, as well as for that of TTS …”

Section: Baseline Clinical Characteristics Of Patients With Takotsubomentioning

confidence: 99%

Prevalence and long‐term prognostic impact of malignancy in patients with Takotsubo syndrome

Möller

Stiermaier

Graf

et al. 2017

European J of Heart Fail

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Section: Baseline Clinical Characteristics Of Patients With Takotsubomentioning

confidence: 99%

Prevalence and long‐term prognostic impact of malignancy in patients with Takotsubo syndrome

Möller

Stiermaier

Graf

et al. 2017

European J of Heart Fail

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“…For example, a Chinese patient with restrictive lung disease, a rapidly progressive proximal myopathy, rigid spine, bilateral Achilles tendon tightening, hypertrophic cardiomyopathy with restrictive physiology and a prolonged QT interval had de novo mutation at c.626C > T (p.Pro209Leu) which is situated in the conserved Ile-Pro-Val motif that is a site of interaction between BAG3 and the Hsps as well as a second non-synonymous change c.772C > T (p.Arg258Trp) which was not situated in a known structural domain [20]. Interestingly, polymorphisms of BAG3 may also play a role in the pathogenesis of tako-tsubo cardiomyopathy [21]. …”

Section: Bag3 Mutants Myofibrillar Myopathy and Dilated Cardiomyopathymentioning

confidence: 99%

BAG3: a new player in the heart failure paradigm

et al. 2015

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BAG3 is a cellular protein that is expressed predominantly in skeletal and cardiac muscle but can also be found in the brain and in the peripheral nervous system. BAG3 functions in the cell include: serving as a co-chaperone with members of the heat-shock protein family of proteins to facilitate the removal of misfolded and degraded proteins, inhibiting apoptosis by interacting with Bcl2 and maintaining the structural integrity of the Z-disk in muscle by binding with CapZ. The importance of BAG3 in the homeostasis of myocytes and its role in the development of heart failure was evidenced by the finding that single allelic mutations in BAG3 were associated with familial dilated cardiomyopathy. Furthermore, significant decreases in the level of BAG3 have been found in end-stage failing human heart and in animal models of heart failure including mice with heart failure secondary to trans-aortic banding and in pigs after myocardial infarction. Thus, it becomes relevant to understand the cellular biology and molecular regulation of BAG3 expression in order to design new therapies for the treatment of patients with both hereditary and non-hereditary forms of dilated cardiomyopathy.

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“…Additionally, a variety of heterozygous mutations in BAG3, many of which are nonsense or frameshift mutations consistent with loss of function, cause autosomal dominant familial dilated cardiomyopathy (8)(9)(10)(11). BAG3 has also been associated with acquired forms of cardiomyopathy, such as stress (Takotsubo) cardiomyopathy (12)(13)(14). Alternatively, a common coding polymorphism in BAG3 was associated with a significantly lower odds ratio for developing idiopathic dilated cardiomyopathy, suggesting that this polymorphism could be protective (9).…”

Section: Introductionmentioning

confidence: 99%

A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress

Judge¹,

Pérez-Bermejo²,

Truong³

et al. 2017

JCI Insight

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Polymorphisms of the antiapoptotic protein bag3 may play a role in the pathogenesis of tako-tsubo cardiomyopathy

Cited by 28 publications

References 14 publications

Prevalence and long‐term prognostic impact of malignancy in patients with Takotsubo syndrome

Prevalence and long‐term prognostic impact of malignancy in patients with Takotsubo syndrome

BAG3: a new player in the heart failure paradigm

A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress

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