Polymorphisms of the IL27 gene in a Chinese Han population complicated with pre-eclampsia

Abstract

IL-27 could inhibit the development of Th17 cells, and the Th17/regulatory T-cell imbalance may reverse maternal tolerance in pre-eclampsia (PE). The aim of this study was to investigate the association between genetic polymorphisms in IL27 with PE. Three SNPs in IL27 (rs153109, rs17855750, and rs181206) were genotyped in a Chinese Han cohort of 1040 PE patients and 1247 normal pregnant women using the TaqMan allelic discrimination real-time PCR method. The CC genotypic distribution of rs153109 was significantly higher among cases than controls (19.1% versus 13.3%, odds ratio [OR]: 1.54, 95% confidence interval [CI]: 1.23–1.93, p < 0.001), and the CT genotype was found to be significantly lower in cases than controls (41.7% versus 49.0%, OR: 0.74, 95% CI: 0.63–0.88, p < 0.001), disputing existing reports indicating the allele frequency of rs153109 is not significantly different between PE patients and controls. Additionally, the CC genotype of rs153109 was significantly more prevalent in PE cases than controls using a recessive model (p < 0.001). The allelic and genotypic frequencies of rs17855750 and rs181206 were not significantly different between two groups. Our results reveal that IL27 polymorphisms may be involved in the development of PE in Chinese Han population.

Differences in epidemiology of patients with preeclampsia between China and the US (Review)

“…Studies of the Chinese Han population have reported that the vitamin D receptor gene with the G allele of rs2228570, the IL-10-1082A/G and -819T/C, IL-27 rs153109 and rs17855750 variants, as well as 11β-hydroxysteroid dehydrogenase and killer-cell immunoglobulin-like receptor genetic variations are related to PE (24-26). Cyclooxygenase-1195A homozygosity and variant growth arrest-specific 6 +1332 T allele were also indicated to correlate with a reduced PE risk in the Chinese Han population (27)(28)(29).…”

The role of interleukins in preeclampsia: A comprehensive review

“…Results from studies regarding polymorphisms of IL‐27 gene are controversial. Liu et al reported that the CC genotype of rs153109 was associated with a higher risk of PE (OR = 1.54, 95% CI: [1.23‐1.93]), while the CT genotype was shown to be protective (OR = 0.74, 95% CI: [0.63‐0.88]). Distributions of genotypes and alleles of rs17855750 and rs181206 showed no difference in study cases and controls.…”

Potential Contribution of IL-27 and IL-23 Gene Polymorphisms to Multiple Sclerosis Susceptibility: An Association Analysis at Genotype and Haplotype Level

“…He and colleagues found a strong correlation between the IL-27- A964G variant and GD, but no correlation was found between autoimmune thyroid diseases and the IL-27- T4730C variant [ 84 ]. We obtained preliminary results in a pilot study in which we analyzed the possible role of the IL-27- T4730C polymorphism in Multiple Sclerosis [ 85 ].…”