Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia

Chedraui, Peter; Salazar-Pousada, Danny; Villao, Alejandro; Escobar, Gustavo S.; Ramírez, Cecibel; Hidalgo, Luis; Pérez‐López, Faustino R.; Genazzani, Andrea R.; Simoncini, Tommaso

doi:10.3109/09513590.2014.895807

Cited by 23 publications

(27 citation statements)

References 50 publications

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“…We found that the previous meta-analysis did not include at least 5 studies in the last updated meta-analysis [4,36,41,54,55]. In addition, two new studies have been published since July 2014 [11,56]. We excluded two studies in the previous meta-analyses after evaluating the articles.…”

Section: Discussionmentioning

confidence: 96%

“…1), including 7398/11222 cases/controls for MTHFR C677T (Table 1) and 1103 /988 cases/controls for MTHFR A1298C (Table 3, Table 4). The distribution of genotypes in the controls of the studies was in agreement with HardyWeinberg equilibrium, except for four studies [11,33,45,46]. The search results were combined and duplicates were removed.…”

Section: Eligible Studiesmentioning

confidence: 99%

“…Women with the MTHFR C677T and A1298C mutations displayed higher plasma HCy levels as compared to controls with normal genotype [11][12][13]. The MTHFR C677T, which involves a cytosine (C) to a thymine (T) substitution at position 677, changes an alanine to a valine in the enzyme.…”

Section: Introductionmentioning

confidence: 99%

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Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis

Yang

Tang

et al. 2015

J Assist Reprod Genet

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Objectives MTHFR C677T and A1298C have been associated with the risk of preeclampsia (PE), but with conflicting results. We performed this meta-analysis to derive a more precise estimation of the association between MTHFR polymorphisms and PE. Study design An electronic search of PubMed and Chinese Biomedicine database was conducted to select studies for meta-analysis. 54 case controlled studies containing MTHFR C677T and A1298C gene polymorphisms were chosen, and odds ratio (OR) with confidence interval (CI) was used to assess the strength of this association. Result These studies evaluated 7398 cases and 11230 controls for MTHFR C677T. The overall results suggested that MTHFR C677T was associated with the risk of PE. (T vs. C: OR = 1.157, 95 % CI: 1.057-1.266, p=0.002; TT+CT vs. CC: OR=1.165, 95 % CI 1.049-1.293, P = 0.004; TT vs. CT + CC: OR = 1.371, 95 % CI: 1.153-1.63, p < 0.001). We also evaluated 1103 cases and 988 controls for MTHFR A1298C but could not demonstrate an increased risk of PE for this polymorphism (p=0.667). A symmetric funnel plot, the Egger's test (p = 0.819) suggested a lack of publication bias. ConclusionThis meta-analysis supports the idea that MTHFR C677T genotype is associated with increased risk for PE, especially in the case of Asians and Caucasians.

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Section: Discussionmentioning

confidence: 96%

Section: Eligible Studiesmentioning

confidence: 99%

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Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis

Yang

Tang

et al. 2015

J Assist Reprod Genet

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“…Two specific SNPs of the MTHFR gene have been reported: C677T (leading to valine substitution at amino acid 222) [10], and A1298C (leading to an alanine substitution at aminoacid 429) [11]. Both mutations have been studied in women with PE [12,13]. We previously reported that the prevalence of the CC mutant genotype of the A1298C polymorphism, yet not the TT mutant genotype of C677T, was higher among women with PE [12]; and this mutation was related to higher maternal plasma HCY levels.…”

Section: Introductionmentioning

confidence: 96%

Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in the placenta of pregnancies complicated with preeclampsia

Chedraui

Andrade

Salazar-Pousada

et al. 2015

Gynecological Endocrinology

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“…Some studies have suggested that this mutation could elevate blood homocysteine [17,18] and is believed to contribute to fetal nervous system malformation and spina bifida cystica, and may affect other aspects of fetal development as well [19,20]. The A-C substitution (A1298C) of MTHFR has a similar effect with C677T during pregnancy [21]. Moreover, MTRR 66GG also has the risk of elevating blood homocysteine [22] and is associated with fetal intrauterine growth restriction [23].…”

Section: Discussionmentioning

confidence: 99%

Individualized Supplementation of Folic Acid According to Polymorphisms of Methylenetetrahydrofolate Reductase (MTHFR), Methionine Synthase Reductase (MTRR) Reduced Pregnant Complications

Li¹,

Jiang²,

Xu³

et al. 2015

Gynecol Obstet Invest

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Objective: This study aimed to detect the genotype distributions and allele frequencies of methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms of pregnant women in Jiaodong region in China, and to investigate whether folic acid supplementation affect the pregnancy complications. Setting: A total of 7,812 pregnant women from the Jiaodong region in Shandong province in China. Methods: By using Taqman-MGB, 2,928 pregnant women (case group) were tested for the genotype distributions and allele frequencies of MTHFR C677T, A1298C and MTRR A66G polymorphisms. Folic acid metabolism ability was ranked at four levels and then pregnant women in different rank group were supplemented with different doses of folic acid. Their pregnancy complications were followed up and compared with 4,884 pregnant women without folic acid supplementation (control group) in the same hospital. Results: The allele frequencies of MTHFR C677T were 49.1 and 50.9%; those of MTHFR A1298C were 80.2 and 19.8%, and those of MTRR A66G were 74.1 and 25.9%. After supplemented with folic acid, the complication rates in different age groups were significantly reduced, especially for gestational diabetes mellitus and hypertension. Conclusion: Periconceptional folic acid supplementation and healthcare following gene polymorphism testing may be a powerful measure to decrease congenital malformations.

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Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia

Abstract: Prevalence of the CC mutant genotype of the A1298C polymorphism was higher among PE women. This mutation among PE women was related to increased neck circumference and higher HCy levels. Future research should aim at linking these gestational findings with obesity and cardiovascular risk.

Cited by 23 publications

References 50 publications

Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis

Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis

Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in the placenta of pregnancies complicated with preeclampsia

Individualized Supplementation of Folic Acid According to Polymorphisms of Methylenetetrahydrofolate Reductase (MTHFR), Methionine Synthase Reductase (MTRR) Reduced Pregnant Complications

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