Polymorphisms of the Peroxisome Proliferator-Activated Receptor-γ (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus

Abstract

ᅟThe aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1α) gene (rs8192673) are associated with obesity indexes (BMI, waist circumference) in subjects with type 2 diabetes mellitus (T2DM) in Caucasian population. The second aim was to find an association of both polymorphisms with T2DM.MethodsTwo exonic SNPs of both genes rs1801282 of the PPAR-γ gene and rs8192673 of the PGC-1α gene) were genotyped in 881 unrelated Slovene subjects (Caucasians) with T2DM and in 348 subjects without T2DM (control subjects).ResultsFemale homozygotes with the CC genotype of the rs8192673 had higher waist circumference in comparison with subjects with other genotypes. Homozygotes (females, males) with wild allele (Pro) of the rs1801282 (Pro12Ala polymorphism) had higher waist circumference in comparison with subjects with other genotypes. In the study, there were no differences in the distributions of the rs8192673 and the rs1801282 genotypes between patients with T2DM and controls. Linear regression analyses for both polymorphisms were performed and demonstrated an independent effect of the rs1801282 of the PPAR-γ on waist circumference in subjects with T2DM, whereas an independent effect on waist circumference was not demonstrated for the rs8192673 of the PGC-1α gene.ConclusionsIn a large sample of the Caucasians the rs8192673 of the PGC-1α gene and the rs1801282 of the PPAR-γ gene were associated with waist circumference in subjects with T2DM.

Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors

“…The frequency of Ala allele for PPARG polymorphism among our adolescents was similar to those found in studies with other populations, such as Polish (15.5%) [21], Chinese (10.7%) [22], and Hungarian obese children and adolescents (14.6%) [23]. Studies have reported that PPARG Pro12Ala polymorphism is associated with obesity, insulin sensitivity, and type 2 diabetes [24]. Moreover, a meta-analysis considering the presence/absence of the Ala allele (dominant effect) as the exposure and BMI as the outcome, analyzed results from 49,902 adults (Caucasian, Asian, Mexican-Hispanic, and AfricanAmerican).…”

Orthostatic hypotension in diabetic patients—10-year follow-up study

“…In diabetes mellitus, high BMI predicts the development of chronic complications (Kruzliak, Haley, Starcevic, et al, 2015;Sabaka, Kruzliak, Gaspar, et al, 2013;Valensi, Paries, Attali, & French Group for Research and Study of Diabetic Neuropathy, 2003). Few studies however described negative correlation with BMI and presence of orthostatic hypotension (Fedorowski et al, 2010).…”

Relationships between <em>FTO</em> rs9939609, <em>MC4R</em> rs17782313, and <em>PPAR&gamma;</em> rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men &ndash; a preliminary study

“…Dytfeld and Horst-Sikorska29 highlighted the role of diet in metabolic disorders in patients with the PPARγ rs1801282 polymorphism and modification of the genotype by environmental factors, which can lead to diverse phenotypes. On the other hand, Kruzliak et al31 conducted analyses in a group of >1000 Caucasians with T2DM and proved that the homozygous Slovene females with wild-type alleles had lower WC in comparison with homozygous females with mutated alleles. All in all, these findings were not replicated in this study, probably due to gender and age differences.…”

“…Healthy nonsmoking men carrying the mutant allele of rs1801282 polymorphism are at a high risk for MetS and insulin resistance 30. In a large study of the Caucasians, the rs1801282 was linked to WC in patients with T2DM 31. However, it must be remembered that other researchers found no such associations 32.…”