2000
DOI: 10.1161/01.res.86.8.834
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Polymorphisms of the β 2 -Adrenergic Receptor Determine Exercise Capacity in Patients With Heart Failure

Abstract: The beta(2)-adrenergic receptor (beta(2)AR) exists in multiple polymorphic forms with different characteristics. Their relevance to heart failure (HF) physiology is unknown. Cardiopulmonary exercise testing was performed on 232 compensated HF patients with a defined beta(2)AR genotype. Patients with the uncommon Ile164 polymorphism had a lower peak VO(2) (15.0+/-0.9 mL. kg(-1). min(-1)) than did patients with Thr164 (17.9+/-0.9 mL. kg(-1). min(-1), P<0.0001). The percentage achieved of predicted peak VO(2) was… Show more

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Cited by 164 publications
(88 citation statements)
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“…37 In another heart failure study, the Ile164, Gly16 and the combination of Gly16 and Gln27 variants predicted lower cardiopulmonary exercise capacity. 80 More recently, the Arg16 allele has been linked to higher heart rate and elevated cardiac adrenergic drive (measured by norepinephrine spillover) and the Gln27 allele predicted a more favorable response to carvedilol in heart failure subjects. 81,82 Thus, polymorphisms in ADRB1 and ADRB2 have support for biological relevance in both in vitro and clinical studies.…”
Section: Pharmacogenetics Of the Human Adrbsmentioning
confidence: 99%
“…37 In another heart failure study, the Ile164, Gly16 and the combination of Gly16 and Gln27 variants predicted lower cardiopulmonary exercise capacity. 80 More recently, the Arg16 allele has been linked to higher heart rate and elevated cardiac adrenergic drive (measured by norepinephrine spillover) and the Gln27 allele predicted a more favorable response to carvedilol in heart failure subjects. 81,82 Thus, polymorphisms in ADRB1 and ADRB2 have support for biological relevance in both in vitro and clinical studies.…”
Section: Pharmacogenetics Of the Human Adrbsmentioning
confidence: 99%
“…These studies were crosssectional rather than prospective analyses, conducted in patients with diverse cardiac pathologies and performed in patients of whom a proportion were receiving b-AR blocker therapy. [14][15][16] In contrast, some studies have shown b 2 -AR genotype-specific effects on LV structure and function after b-AR blocker therapy. 16,17 However, whether the genetic effects noted in these studies 16,17 were determined by independent actions of b 2 -AR genotype, or interactions between genotype and the well known effects of b-AR blockers on b-AR function, 3,4 is not clear.…”
Section: Introductionmentioning
confidence: 97%
“…[14][15][16] In contrast, some studies have shown b 2 -AR genotype-specific effects on LV structure and function after b-AR blocker therapy. 16,17 However, whether the genetic effects noted in these studies 16,17 were determined by independent actions of b 2 -AR genotype, or interactions between genotype and the well known effects of b-AR blockers on b-AR function, 3,4 is not clear. Therefore, in the present study, to assess whether b 2 -AR genotypes determine LV dimensions and pump function independent of b-AR blockers, we evaluated the relationship between Arg16Gly and Gln27Glu polymorphisms of the b 2 -AR gene and LV dimensions and systolic function in patients with idiopathic dilated cardiomyopathy (IDC) before and 6 months after receiving medical therapy other than b-AR blockers.…”
Section: Introductionmentioning
confidence: 97%
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