Polymorphisms of TNF microsatellite marker a and HLA-DR-DQ in diabetes mellitus—a study in 609 Swedish subjects

Törn, Carina; Hillman, Magnus; Sanjeevi, Carani B.; Landin‐Olsson, Mona

doi:10.1016/j.humimm.2006.04.002

Cited by 11 publications

(10 citation statements)

References 37 publications

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“…The most common TNFa microsatellite in the European population was TNFa2 with a frequency varying between 20.8% in the French sample and 32% in a Danish study [7]. However our study placed TNFa2 by itself as the second most represented type (16.4%), preceded only by TNFa6 (18.9%).…”

Section: Discussioncontrasting

confidence: 73%

Genetic Polymorphisms at TNF Microsatellites from the HLA CLASS III Region in a South Tunisian Population

Mahfoudh¹,

Kamoun²,

Gaddour³

et al. 2014

OALib

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To evaluate the tumor necrosis factor (TNF) a-b-c microsatellite polymorphism in South Tunisia, we studied 123 healthy unrelated controls from South Tunisia. TNF microsatellite alleles were typed using genomic DNA amplified with specific primers. Statistical analyses were performed using ARLEQUIN software. The TNFa6 (18.9%), TNFa2 (16.4%), TNFb5 (41.9%), and TNFc1 (68.7%) were the most frequent alleles in our population, whereas the TNFa8 and TNFb2 were the least frequent alleles. To investigate the association among the three microsatellites, a detailed haplotype analysis was performed. 236 different haplotypes were possible but there was only 15 haplotypes had frequencies greater than 2%. In our population the most frequent haplotype TNFcab were "TNFc1a6b5" (10.03%). These results may be informative for studies of the associations of individual TNF region markers with secretion levels, immunity, and disease.

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Section: Discussioncontrasting

confidence: 73%

Genetic Polymorphisms at TNF Microsatellites from the HLA CLASS III Region in a South Tunisian Population

Mahfoudh¹,

Kamoun²,

Gaddour³

et al. 2014

OALib

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“…Strong LD between TNF2 and HLA-DRB1*0301 alleles was also found in the present study, which indicates that the association of this TNF-a variation may actually not be independent. Moreover, several other polymorphisms within the TNFA gene may also confer/modify the risk for T1D, including TNFa microsatellite (Törn et al 2006) or -1031 T/C, -863 C/A, and -857 C/T SNPs (Hamaguchi et al 2000).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the Genes Encoding TGF-β1, TNF-α, and IL-6 Show Association with Type 1 Diabetes Mellitus in the Slovak Population

Javor

Ferenčík

Bucová

et al. 2010

Arch. Immunol. Ther. Exp.

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Numerous cytokines have been shown to participate in the pathogenesis of type 1 diabetes (T1D). As gene polymorphisms can influence cytokine production or function, they may potentially contribute to genetic predisposition to the disease. The aim of this study was therefore to investigate the role of 22 single nucleotide polymorphisms (SNPs) in 13 cytokine and cytokine receptor genes in genetic susceptibility to T1D. Polymerase chain reaction with sequence-specific primers was used to genotype cytokine SNPs and HLA-DRB1 alleles in 151 diabetics and 140 healthy individuals of Slovak origin. Univariate analysis showed that transforming growth factor (TGF)-beta1 codon 10 TT homozygotes were significantly more susceptible to developing T1D than C allele carriers (P (c) = 0.0066, OR = 2.46). Furthermore, tumor necrosis factor (TNF)-alpha -308 A allele carriers were also significantly overrepresented among the diabetics (P (c) = 0.0031, OR = 2.62); however, the association of the -308 A allele with T1D might be due to its strong linkage disequilibrium with the susceptibility allele HLA-DRB1*0301. An association was also found with interleukin (IL)-6 -174 G/C and nt565 G/A SNPs; however, its significance was lost when statistical correction was applied. These data suggest that the TGF-beta1 codon 10 SNP is among numerous genetic variations with small individual effects on T1D development. Moreover, a possible role of TNF-alpha and IL-6 SNPs cannot be ruled out, although their association with T1D was due to strong LD with the HLA class II susceptibility allele or did not withstand statistical correction, respectively.

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“…These SNPs have been investigated in T1DM patients from different ethnic groups [7][8][9], demonstrating considerable differences in allele frequencies among them.…”

Section: Introductionmentioning

confidence: 99%

Genetic evaluation of the TNF-α −238G>A and −308G>A promoter polymorphisms in Croatian patients with type I diabetes

Korolija

Medvidović²,

Pavković³

et al. 2010

Human Immunology

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Polymorphisms of TNF microsatellite marker a and HLA-DR-DQ in diabetes mellitus—a study in 609 Swedish subjects

Cited by 11 publications

References 37 publications

Genetic Polymorphisms at TNF Microsatellites from the HLA CLASS III Region in a South Tunisian Population

Genetic Polymorphisms at TNF Microsatellites from the HLA CLASS III Region in a South Tunisian Population

Polymorphisms in the Genes Encoding TGF-β1, TNF-α, and IL-6 Show Association with Type 1 Diabetes Mellitus in the Slovak Population

Genetic evaluation of the TNF-α −238G>A and −308G>A promoter polymorphisms in Croatian patients with type I diabetes

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