Polymorphonuclear leukocyte activity and ventricular arrhythmia in acute myocardial infarction

Modified Cretan Mediterranean Diet in the Prevention of Coronary Heart Disease and Cancer

“…One of the main mechanisms underlying the sudden onset of acute syndromes, including unstable angina, myocardial infarction and sudden death, is the erosion or rupture of an atherosclerotic lesion [34,35] which triggers thrombotic complications and considerably enhances the risk of ventricular arrhythmias [36,37]. Leuko- cytes have been also implicated in the occurrence of ventricular arrhythmias in the clinical and experimental settings [38,39] and they contribute to myocardial damage during both ischemia and reperfusion [38]. Clinical and pathological studies showed the importance of inflammatory cells and immune mediators in the occurrence of acute CHD events [32,40,41] and prospective epidemiological studies showed a strong and consistent association between acute CHD and systemic markers of inflammation [42,43].…”

The dietary prevention and treatment of coronary heart disease in the new millennium

“…[24][25] One of the main mechanisms underlying the sudden onset of acute coronary syndromes, including unstable angina, MI and sudden death, is the erosion or rupture of an atherosclerotic lesion which triggers thrombotic complications, considerably enhancing the risk of ventricular arrhythmias. Leukocytes have been also implicated in the occurrence of ventricular arrhythmias in both clinical and experimental settings, 26,27 and contribute to myocardial damage during both ischemia and reperfusion. Clinical and pathological studies demonstrate the importance of inflammatory cells and immune mediators in the occurrence of acute CHD events, and prospective epidemiological studies show a strong and consistent association between acute CHD and systemic markers of inflammation.…”

Purine metabolism in the heart

“…Anti-arrhythmic Inhibition of catecholamine release Attenuation of response to catecholamines 9 Figure 1 The multiple actions of adenosine, relevant for its cardioprotective properties [8], its antilipolytic action [22], its inhibition of leucocyte activation [23], and its 'verapamil-like' antagonism of Ca 2+ [21]. But the exact mechanisms involved still remain to be determined.…”