Polymorphonuclear Leukocyte Dysfunction Associated with Feline Leukaemia Virus Infection

Lewis, Mark G.; Duska, Geralyn O.; Stiff, Mary I.; Lafrado, Louis J.; Olsen, Richard G.

doi:10.1099/0022-1317-67-10-2113

Cited by 22 publications

(19 citation statements)

References 19 publications

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“…Decreased activation of neutrophils from FeLV experimentally infected animals during phagocytosis of serum-opsonized particles has been described previously (Lewis et al, 1986). Likewise, neutrophils from FeLV 2 animals were not activated by opsonized particles with serum obtained from FeLV + cats (Lewis et al, 1986).…”

Section: Net Release and Myeloperoxidase (Mpo) Activitymentioning

confidence: 88%

“…Previous studies have shown that FeLV infection impairs neutrophil microbicidal functions and that affected cats are more susceptible to opportunistic infections Lewis et al, 1986). Decreased activation of neutrophils from FeLV experimentally infected animals during phagocytosis of serum-opsonized particles has been described previously (Lewis et al, 1986).…”

Section: Net Release and Myeloperoxidase (Mpo) Activitymentioning

confidence: 99%

“…Thus, exogenous H 2 O 2 generated from NADPH oxidase induced NET release in mammals and release of heterophil extracellular traps in chickens (Fuchs et al, 2007;Chuammitri et al, 2009). FeLV infection inhibits neutrophil activation by inhibition of protein kinase C and a decrease in ROS production Lewis et al, 1986;Lafrado et al, 1987;Dezzutti et al, 1989Dezzutti et al, , 1990Hoffmann-Jagielska et al, 2005).…”

Section: Characterization Of Feline Netsmentioning

confidence: 99%

“…Dysfunction of cellular immunity by FeLV infection, however, is not restricted to T or B cells (Cockerell & Hoover, 1977;Tompkins et al, 1989), as the loss of neutrophil function has also been reported as a consequence of FeLV infection. Moreover, neutrophils from FeLV-infected cats suffer reduced ROS production, phagocytosis and chemotaxis Lewis et al, 1986;Kiehl et al, 1987;Lafrado et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

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Characterization of neutrophil extracellular traps in cats naturally infected with feline leukemia virus

Wardini

Guimarães-Costa

Nascimento

et al. 2009

Journal of General Virology

109

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Feline leukemia virus (FeLV), a common, naturally occurring gammaretrovirus in domestic cats, is associated with degenerative diseases of the haematopoietic system, immunodeficiency and neoplasia. FeLV infection causes an important suppression of neutrophil function, leading to opportunistic infections. Recently, a new microbicidal mechanism named NETosis was described in human, bovine and fish neutrophils, as well as in chicken heterophils. The purpose of the present study was to characterize NETosis in feline neutrophils, as well as to evaluate neutrophil function in FeLV naturally infected symptomatic and asymptomatic cats through the phagocytosis process, release of neutrophil extracellular traps (NETs) and myeloperoxidase (MPO) activity. The results showed that feline neutrophils stimulated with protozoa parasites released structures comprising DNA and histones, which were characterized as NETs by immunofluorescence. Quantification of NETs after neutrophil stimulation showed a significant increase in NET release by neutrophils from FeLV " and FeLV + asymptomatic cats compared with FeLV + symptomatic cats.Moreover, the number of released NETs and MPO activity in unstimulated neutrophils of FeLV + symptomatic cats were higher than those in unstimulated neutrophils from FeLV " and FeLV + asymptomatic cats. This study reports, for the first time, NET release by feline neutrophils, along with the fact that NET induction may be modulated by a viral infection. The results indicate that the NET mechanism appears to be overactivated in FeLV + cats and that this feature could be considered a marker of disease progression in FeLV infection.

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Section: Net Release and Myeloperoxidase (Mpo) Activitymentioning

confidence: 88%

Section: Net Release and Myeloperoxidase (Mpo) Activitymentioning

confidence: 99%

Section: Characterization Of Feline Netsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of neutrophil extracellular traps in cats naturally infected with feline leukemia virus

Wardini

Guimarães-Costa

Nascimento

et al. 2009

Journal of General Virology

109

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“…Recent reports have shown that infection with the human retrovirus, human immunodeficiency virus, results in suppression of mononuclear phagocytic cells (Prince et al, 1985) and polymorphonuclear phagocytic cells (Ras et al, 1984). Lewis et al (1986) have shown that, in addition to lymphoid cell suppression, FeLV-viraemic cats express severely depressed PMN 0000-7273 © 1987 SGM populations as compared to controls in an assay for functional capacity in vitro. In addition, we have shown ) that non-viraemic FeLV-challenged cats express a similar depression in functional activity in vitro.…”

Section: Introductionmentioning

confidence: 99%

Suppression of in vitro Neutrophil Function by Feline Leukaemia Virus (FeLV) and Purified FeLV-p15E

Lafrado¹,

Lewis²,

Mathes

et al. 1987

Journal of General Virology

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Priming of Rabbit Alveolar Macrophages for Enhanced Oxidative Responses by Herpes Simplex Virus Type 2 Infection

Giridhar

Hayakawa

Kucera

et al. 1991

Journal of Leukocyte Biology

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The effect of herpes simplex virus type 2 (HSV-2) infection on the oxidative response in infant and adult rabbit alveolar macrophages (AM) was studied using either phorbol myristate acetate (0.5 microgram PMA/ml) or latex (250 micrograms/ml) as eliciting agents in a chemiluminescence (CL) assay. Results indicated that uninfected infant AM responded to a latex-elicited but not PMA-elicited CL response. HSV-2 infection (moi = 1.0) of infant AM for 2 hr at 37 degrees C did not alter the PMA or latex-elicited CL responses. In contrast, uninfected adult AM exhibited a markedly increased CL response when elicited with either PMA or latex. HSV-2 infection (moi = 1) of adult AM for 2 hr further increased both PMA- and latex-elicited CL responses. Increasing the moi to 10 inhibited both PMA- and latex-elicited CL responses. Incubation of uninfected control and HSV-2 infected adult AM for 18 hr at 37 degrees C resulted in spontaneous priming of the cells for increased CL responses. In the absence of PMA HSV-2 alone failed to elicit a CL response in adult AM. Infection with heat-inactivated HSV-2 (moi = 1.0 before heat inactivation) did not prime adult AM for enhanced CL responses. AM from BCG immunized adult rabbit produced a considerably higher level CL response that nonimmunized AM; however, HSV-2 infection of these cells did not further enhance the response. In summary, these data indicate that adult AM but not infant AM can be primed by active HSV-2 infection for an increased CL response elicited by either PMA or latex.

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Polymorphonuclear Leukocyte Dysfunction Associated with Feline Leukaemia Virus Infection

Cited by 22 publications

References 19 publications

Characterization of neutrophil extracellular traps in cats naturally infected with feline leukemia virus

Characterization of neutrophil extracellular traps in cats naturally infected with feline leukemia virus

Suppression of in vitro Neutrophil Function by Feline Leukaemia Virus (FeLV) and Purified FeLV-p15E

Priming of Rabbit Alveolar Macrophages for Enhanced Oxidative Responses by Herpes Simplex Virus Type 2 Infection

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