Polymorphonuclear leukocytes: Dedicated professional phagocytes

Wade, Barbara H.; Mandell, Gerald L.

doi:10.1016/0002-9343(83)91028-8

Cited by 35 publications

(17 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PMN are altered by the passage from intravascular to extravascular sites (5,15,18,22,(30)(31)(32). This passage is initiated when an inflammatory stimulus results in chemotaxis, a process which leads to the transformation of blood cells into exudate cells.…”

Section: Discussionmentioning

confidence: 99%

Comparative superoxide-generating system of granulocytes from blood and peritoneal exudates

Zimmerli¹,

Lew²,

Cohen³

et al. 1984

Infect Immun

View full text Add to dashboard Cite

Blood polymorphonuclear leukocytes (PMN), upon interaction with specific chemotactic stimuli, leave the blood stream and migrate to tissues. At such a location, and upon contact with invading microorganisms, they generate superoxide (02-) as a part of the respiratory burst of phagocytosis. We have compared the O2-generating system of guinea pig peritoneal exudate PMN with that of peripheral blood PMN from the same species or of human origin. The rate of O2-production by casein-induced guinea pig exudate cells in response to a particulate stimulus (opsonized zymosan) was significantly decreased when compared with peripheral blood PMN. Furthermore, the activation time of the O2--generating system was shorter in exudate than in peripheral blood PMN. Important differences in sensitivity to a metabolic inhibitor were found: (i) Nethylmaleimide increased the activation time of the O2--generating system only in guinea pig exudate cells and not in blood cells; (ii) when N-ethylmaleimide was added after complete activation of the PMN, the O2production rate was inhibited in guinea pig as well as human blood PMN, but not in guinea pig exudate PMN. We conclude that exudation markedly alters one of the most important antibacterial mechanisms of PMN, the superoxide-generating system. 625

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative superoxide-generating system of granulocytes from blood and peritoneal exudates

Zimmerli¹,

Lew²,

Cohen³

et al. 1984

Infect Immun

View full text Add to dashboard Cite

show abstract

“…In the past 20 years, the cellular and mo lecular events occurring during phagocytosis have been studied extensively [2,3], and methods have been developed to study PMNL function [4], During the early occur ring steps that must integrate to allow a PMNL to accomplish its work, the coopera tion between the humoral immune system and the phagocyte is most important. Extrav asation of PMNL from the vascular compart ment and directed migration (chemotaxis) toward the pathogens are achieved by the generation of chemotactic agents.…”

Section: Process Of Phagocytosis and Killing Of Bacterial Pathogens Bmentioning

confidence: 99%

Imbalance between Polymorphonuclear Leukocyte Proteases and Antiproteases in Chronic Pyogenic Infections and Its Relation to the Proteolysis of Complement Component C3

Suter¹

1986

Complement

View full text Add to dashboard Cite

“…Since the polymorphonuclear neutrophil granulocytes (PMN) play a significant role in the control of acute bacterial and fungal infections, in particular, in the early phase as the so‐called “professional” phagocytes responsible for warding off infections, an impediment in the function of PMN will most certainly lead to an increased susceptibility to infections (Faist, et al., 1996; Wade and Mandell, 1983). The activation of PMN ensues by successive and also partly by parallel‐coursing mechanisms (Klein, 1991; Peveri et al., 1988; Schiffmann and Corcoran, 1975; Webster et al., 1980).…”

mentioning

confidence: 99%

Ethanol‐Induced Malfunction of Neutrophils Respiratory Burst on Patients Suffering From Alcohol Dependence

Breitmeier

Becker

Weilbach

et al. 2008

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

The results presented in this study show an impairment in the function of PMN in those patients addicted to alcohol due to the decrease in burst activity. In view of the results of the different stimuli, the second-messenger effects were not evident. A clarification of this phenomenon could well be assumed as an allosteric receptor effect on the burst oxidase, namely, a direct effect on the phagocytosis interaction between circulating granulocytes and causative organisms.

show abstract

Polymorphonuclear leukocytes: Dedicated professional phagocytes

Cited by 35 publications

References 68 publications

Comparative superoxide-generating system of granulocytes from blood and peritoneal exudates

Comparative superoxide-generating system of granulocytes from blood and peritoneal exudates

Imbalance between Polymorphonuclear Leukocyte Proteases and Antiproteases in Chronic Pyogenic Infections and Its Relation to the Proteolysis of Complement Component C3

Ethanol‐Induced Malfunction of Neutrophils Respiratory Burst on Patients Suffering From Alcohol Dependence

Contact Info

Product

Resources

About